ID A0A0R3PBT4_ANGCS Unreviewed; 560 AA.
AC A0A0R3PBT4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Calcium uptake protein 1 homolog, mitochondrial {ECO:0000313|WBParaSite:ACOC_0000118701-mRNA-1};
GN ORFNames=ACOC_LOCUS1188 {ECO:0000313|EMBL:VDM52773.1};
OS Angiostrongylus costaricensis (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae;
OC Angiostrongylus.
OX NCBI_TaxID=334426 {ECO:0000313|Proteomes:UP000050601, ECO:0000313|WBParaSite:ACOC_0000118701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ACOC_0000118701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM52773.1, ECO:0000313|Proteomes:UP000267027}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Costa Rica {ECO:0000313|EMBL:VDM52773.1,
RC ECO:0000313|Proteomes:UP000267027};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane
CC space {ECO:0000256|ARBA:ARBA00004569}.
CC -!- SIMILARITY: Belongs to the MICU1 family. MICU1 subfamily.
CC {ECO:0000256|ARBA:ARBA00038333}.
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DR EMBL; UYYA01000163; VDM52773.1; -; Genomic_DNA.
DR STRING; 334426.A0A0R3PBT4; -.
DR WBParaSite; ACOC_0000118701-mRNA-1; ACOC_0000118701-mRNA-1; ACOC_0000118701.
DR OMA; ALGNIRQ; -.
DR Proteomes; UP000050601; Unplaced.
DR Proteomes; UP000267027; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; IEA:InterPro.
DR CDD; cd15900; EFh_MICU; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039800; MICU1/2/3.
DR PANTHER; PTHR12294:SF1; CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12294; EF HAND DOMAIN FAMILY A1,A2-RELATED; 1.
DR Pfam; PF13833; EF-hand_8; 2.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00022792};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00022792};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000267027};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 299..334
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 492..527
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 149..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 64920 MW; 74BA27FB4EE1580B CRC64;
MLPCRRLPFY SRKAFLSSIS SAENRTGDKS SGDDVDALEA YTMFGNIRKP KRSPFHYTDS
VLKSCFVFGL SSQMLFCSYR CAFRKCGVGY ADFSTTIYDH RPYVWPPLRK YLRLNLYVAV
VGMLLISIDY EWFMRQFSSV GKQMRPEASQ LKPEMSASAN DSDNKSDVDS GANNNEKPKK
KRTGFRERRI IEYEDRIRLY STPDKIFRYF ATLNVLFHVI DKDDESGKFE VFMTPEDFLR
SLTPGVMQPR KYGLDSYKTY QPDKYKHNFS DTTSIFYKLG ENGLISFSDY LFLMTLLSTP
PSDFTLAFKI FDINGDGALD KDEFTKVQYL IMSQTKVGQR HRDHISHNTS FRVASNSALA
RYFFGEDGKK MLSASKFLEF QGSLYNDILR MEFERRDALD GVDGRISETS FGELLLMYAQ
IPAKKQKMML KRLKRKFKHG QGITFEETRA FFEFLYHIED IDMALHFHRL AGFPIDAQLL
QRVARKITNI ELSNHVVDVI ITLFDDNMDG KLSNSEMVAV MRRRMRRGLE RPRDTGLFRL
IDALSICSKR AYQASPFSLN
//
