ID   A0A0R3QPJ2_9BILA        Unreviewed;       748 AA.
AC   A0A0R3QPJ2;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00018388, ECO:0000256|RuleBase:RU000612};
DE            EC=5.3.1.9 {ECO:0000256|RuleBase:RU000612};
OS   Brugia timori.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=42155 {ECO:0000313|Proteomes:UP000050602, ECO:0000313|WBParaSite:BTMF_0000962701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BTMF_0000962701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC         Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC         EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321,
CC         ECO:0000256|RuleBase:RU000612};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 2/4.
CC       {ECO:0000256|ARBA:ARBA00004926, ECO:0000256|RuleBase:RU000612}.
CC   -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|ARBA:ARBA00006604,
CC       ECO:0000256|RuleBase:RU000612}.
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DR   AlphaFoldDB; A0A0R3QPJ2; -.
DR   STRING; 42155.A0A0R3QPJ2; -.
DR   WBParaSite; BTMF_0000962701-mRNA-1; BTMF_0000962701-mRNA-1; BTMF_0000962701.
DR   UniPathway; UPA00109; UER00181.
DR   Proteomes; UP000050602; Unplaced.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05015; SIS_PGI_1; 1.
DR   InterPro; IPR001672; G6P_Isomerase.
DR   InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   InterPro; IPR035476; SIS_PGI_1.
DR   InterPro; IPR006761; Tsg.
DR   PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR   PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR   Pfam; PF00342; PGI; 1.
DR   Pfam; PF04668; Tsg; 1.
DR   PRINTS; PR00662; G6PISOMERASE.
DR   SUPFAM; SSF53697; SIS domain; 1.
DR   PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR   PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE   3: Inferred from homology;
KW   Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW   ECO:0000256|RuleBase:RU000612};
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612}.
SQ   SEQUENCE   748 AA;  84451 MW;  5E96B2487FA9B358 CRC64;
     LKYLQHRCQL NYSSGLLLFS LIDKNEMVAN IIGWVPLLVL CTLLQDLLQA ALDCNETECG
     PRVSKCMLLK ACNCSINRDS ILHNNCSCCN ECIQCLDKQY MQCCACVGLC NPHKEAVHLN
     SYVDRFDQDD EDIIVFDKVA LVNKVGTTYT FPALREYSFD RRGQNMKALR RTHQETNCTV
     VYLDKCMSHE QCSRQCLILG ASMLRWFHTG CCECIGHTCL PYGSTTARCK YCTDFDNSLI
     LILRQYIYVR QDYSDCKFVP KLNLGFSDQL TDIVLSHQGG NGCIYLGDKT TNRTTNCSYT
     SASSFKEDTT DDYAVIFSIA NNQGNSCESK LYSSSIVLLH ITSVSGSPTQ RIDFRVECTH
     AYFAWVLGMG AGANRHIANE MSLHKDSAFI QLQQHFESEC KFLKMVDLFK QDPQRFQKYS
     LKMDTPDGPI LFDYSKNIIN EETMKRLFNL ANSRNVLNMR QDMFSGKKIN FTEGRAVLHT
     ALRNVNNKPL TLDGQNVTDD VNNVLEHMRT FCDQVIRGTW KGYTGEAITD VVNIGIGGSD
     LGPLMVTEAL KHYQVGPNVH FVSNIDGTHL AEVLKKIKPE TTIFIIASKT FTTQETITNA
     TSAKEWFLSK AVNPAAVAKH FVALSTNGPK VREFGIDENN MFGFWDWVGG RYSLWSAIGL
     SIAVHIGFDN FSQLLKGASA ADEHFLNEPI EKNIPIIMAL LGVLYINCFK AETHALLPYD
     QYLHRFAAYF QQGDMESNGK FMMRFPII
//