ID   A0A0R3QSJ7_9BILA        Unreviewed;       687 AA.
AC   A0A0R3QSJ7;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|RuleBase:RU365058};
GN   ORFNames=BTMF_LOCUS8731 {ECO:0000313|EMBL:VDO29239.1};
OS   Brugia timori.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=42155 {ECO:0000313|Proteomes:UP000050602, ECO:0000313|WBParaSite:BTMF_0001069901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BTMF_0001069901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO29239.1, ECO:0000313|Proteomes:UP000280834}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent, however specific
CC       DNA sequences that define origins of replication have not been
CC       identified so far. ORC is required to assemble the pre-replication
CC       complex necessary to initiate DNA replication.
CC       {ECO:0000256|RuleBase:RU365058}.
CC   -!- SUBUNIT: ORC is composed of six subunits.
CC       {ECO:0000256|RuleBase:RU365058}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU365058}.
CC   -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC       ECO:0000256|RuleBase:RU365058}.
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DR   EMBL; UZAG01016568; VDO29239.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R3QSJ7; -.
DR   STRING; 42155.A0A0R3QSJ7; -.
DR   WBParaSite; BTMF_0001069901-mRNA-1; BTMF_0001069901-mRNA-1; BTMF_0001069901.
DR   Proteomes; UP000050602; Unplaced.
DR   Proteomes; UP000280834; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041083; AAA_lid_10.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR   PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17872; AAA_lid_10; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU365058};
KW   DNA replication {ECO:0000256|RuleBase:RU365058};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW   Nucleus {ECO:0000256|RuleBase:RU365058};
KW   Reference proteome {ECO:0000313|Proteomes:UP000280834}.
FT   DOMAIN          353..503
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
SQ   SEQUENCE   687 AA;  77769 MW;  59B7A3E50EBE69F1 CRC64;
     MFINKNVLWD EKSENAISDS LMAKDEGNEN ISNKRILPKR KAKLMGRRYF EDLFVLNPPP
     NKRSRSSLVL QQAKLVPVFN YDDNLNRFGL EKEDSDEDSE NIKSKDLDAS RISLPSTLPS
     TVIDVSRTCK RRVSVASKIC KSKKSSIWKQ KIGTSDDGFS LHKSFKLSDK VDLVDGEVQK
     SKSEKVDENL EKPFKRIDGL YSNHCKKPFI IVKRTKVFAG AKFINDKHSS LGQGSEDNDG
     GKDFEFSGIL ENLTELDSHS GTNSNIHSEK NLKIRRQYNS VCKSRRLIAE KKSTDQYATC
     GIISNVCAIR VETLEAVYRR LHTSEIPERL PCREAEFDRI CAFIKGCVTN DAISQAMYVS
     GVPGTGKTAT VLQAVRYLKA SENFSGFNFV AVNAMELSDP KQIFVKIYQD LFSLKKKIAP
     KTARKKLNHI FQYHDKKRLP IIVLVDELDL LNTKRQEIIY DIFNWSANEE SLVSVIAIAN
     TLDLPERLFS QRVSSRLGAN RLCFQPYDHD EVAYIIRDRL RNSTAVEAEA IELASRKVAA
     ISGDLRKALD ILRSATELAI NANQKQLTMK NVQEAIRQAS TSVRVELIRA LPRHSILLLR
     AALAEQLSSG LDEFQFHLLF KQYRLQCNVA NINPMSTSST YRNAMEMCSE RLLIAASGTG
     SMSRRFRLGM TTHDIQFAFK QVDESVF
//