ID   A0A0R3R097_9BILA        Unreviewed;       711 AA.
AC   A0A0R3R097;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Ras-GAP domain-containing protein {ECO:0000313|WBParaSite:BTMF_0001342101-mRNA-1};
GN   ORFNames=BTMF_LOCUS11437 {ECO:0000313|EMBL:VDO39055.1};
OS   Brugia timori.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=42155 {ECO:0000313|Proteomes:UP000050602, ECO:0000313|WBParaSite:BTMF_0001342101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BTMF_0001342101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO39055.1, ECO:0000313|Proteomes:UP000280834}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAG01018314; VDO39055.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R3R097; -.
DR   STRING; 42155.A0A0R3R097; -.
DR   WBParaSite; BTMF_0001342101-mRNA-1; BTMF_0001342101-mRNA-1; BTMF_0001342101.
DR   Proteomes; UP000050602; Unplaced.
DR   Proteomes; UP000280834; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR045046; Vps9-like.
DR   PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000280834}.
FT   DOMAIN          155..365
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          558..671
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          27..54
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        558..595
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        626..662
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   711 AA;  79660 MW;  F107824BAB61845E CRC64;
     MDLCNEHSGL DTLTMLCERL RSEKLLVASE LDTLQRLNEE VDNAQSELAH LAWICRQEQT
     ILSRLINSHP DVRPENCCFL TSQFDSACFI HGYRRIDGQH YSSVTELLNL LLNSPNLVAE
     ILHIADQTLK SNDSPFFELV SCVYSLLYGC SVFPEDERRV LETLFHLLDI QLASHSDPRL
     LLRRGNVSFC QLYRLFSEGM YSAKIFLTAA LHDPVMFVLS QDDVFLDIEP TKTLIRFPAE
     ERRRRFGEDE NSLTFLQNLT AHRRYIESKL VSVANRFIRA ITDAMSCFPQ SLGCIVRRLY
     TVLVDHRKLS REQATLICTD LIFTYFICPA IANPETLGVI SDTPVTYIAR FNLMQIGQIL
     QTLAIAPFEP PSSHIAHFYS QFDQQSMSCV VQHVLATHGE SIESICAVST ESPPQVVEQF
     VRRMFVGTIA ELDCLISAVR CFATGPVSDE SIRRALTGLL QRLPIKLSRD DIPNFGVVGF
     QERSHSNERN ADPFFTDTRT LDLIQSGYHR GLRFKHGKST ESTESGRIQI ENIEVLVFPL
     GESREPLGMC SEEKFMESVR NPQRVRKHKT SDESAEKRTR FVDTESIDRT TDGGSDDEAA
     SLSSSIEGNA DGMDDDAEDV STLPDNFSDV VPSSANVSGR GSPSVSDPAS NRGGSRSARS
     AAPTNGGKLK GGISRLSDVF QSIVNAINRK TVLKIRYHTE KVNSVFSMIS K
//