ID A0A0R3R7M5_9BILA Unreviewed; 313 AA.
AC A0A0R3R7M5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=BTMF_LOCUS14011 {ECO:0000313|EMBL:VDO47664.1};
OS Brugia timori.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=42155 {ECO:0000313|Proteomes:UP000050602, ECO:0000313|WBParaSite:BTMF_0001602701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BTMF_0001602701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO47664.1, ECO:0000313|Proteomes:UP000280834}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. STE20 subfamily.
CC {ECO:0000256|ARBA:ARBA00008874}.
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DR EMBL; UZAG01020709; VDO47664.1; -; Genomic_DNA.
DR STRING; 42155.A0A0R3R7M5; -.
DR WBParaSite; BTMF_0001602701-mRNA-1; BTMF_0001602701-mRNA-1; BTMF_0001602701.
DR Proteomes; UP000050602; Unplaced.
DR Proteomes; UP000280834; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR InterPro; IPR001180; CNH_dom.
DR PANTHER; PTHR47096:SF1; CNH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47096; MISSHAPEN LIKE KINASE 1; 1.
DR Pfam; PF00780; CNH; 1.
DR SMART; SM00036; CNH; 1.
DR PROSITE; PS50219; CNH; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000280834};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 95..313
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
SQ SEQUENCE 313 AA; 35033 MW; 1F43DD9AEE1A66D3 CRC64;
MLAFQFPSGV NSLPRIQAPL AARDREKSFV AYFGAGMSGS GTVNRPGRAQ DTNQVYLLYM
IEVQVNVNPN PAAASNGLHS DGDAPEIRKY KKKFSGDILC AALWGVNLLI GTDSGLMLLD
RSGQGKVYQL ITRRRFEQMT VLEGQNILVT ISGRKRRIRV YYLSWLKQKI LRTEGVSGVE
LEKRNGWVNV GDLQGAVHFK IVRYERIKFL VVGLESTVEI YAWAPXXXXX LVVGLESTVE
IYAWAPKPYH KFMAFKAFSQ LTHLPLIVDL TVEKNSRLKV LYGSREGFHA IDLDSGSIDD
IYTPANVCCY SSY
//
