ID A0A0R3RW96_9BILA Unreviewed; 1152 AA.
AC A0A0R3RW96;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Rap guanine nucleotide exchange factor 2 {ECO:0000313|WBParaSite:EEL_0000642401-mRNA-1};
OS Elaeophora elaphi.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000642401-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EEL_0000642401-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR AlphaFoldDB; A0A0R3RW96; -.
DR STRING; 1147741.A0A0R3RW96; -.
DR WBParaSite; EEL_0000642401-mRNA-1; EEL_0000642401-mRNA-1; EEL_0000642401.
DR Proteomes; UP000050640; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF249; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 36..81
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 469..587
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 588..659
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 823..911
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 936..1152
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 155..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 129931 MW; 9712E0CB7711CD3D CRC64;
MESYKEAFIA AIAKEPSTRT DEDLKVIYSN LRRLDVFHNL NDAPLRAICC TARFETHPAN
FILFRQGQVA TCWYILLSGC VFMDEQIYLP CGWFGKRNGL DYRRKNDCIV LQPAEMIVID
YPDVKHIKVN KGHMCSTGSS GRLRNSLCAL SATPMPSPSG AVTVSIRSGA DPATSNSSLP
PPSRLYKTGK ASSISTTESP VSRCERKKHR SFRRERDDIC PSDAPGYAST YKSQVYLNGL
SVDADTRLKV KHKTRKSNSV SSPNCEVYTH LSSTASSSAN EDDLHGLPEA AVDSEEDDES
CPSYDSFHEL KDSVRECLEK EPFERTADDI CTLLHMSALA TLPLSIKRQL CLKMVFAVVS
EANTVVMQHN ERIDAWSVIV NGQVEVVLPD GERIEYKLGD SFGVRPDLVP QYHVGVMRTL
VDDCEFVLVE HRDYCNIMST ISEHIEQHSD GITGEIVSEI ERRSVGNQMG QVLIKANRDK
LIEHLVEERD TAVDAHYIED FLLMYRVFIS DPTMIFEKLM HWFAESNLRD KIARIVLLWV
NNHFNDFECN GEMMQLLDRF EQALERDQMH SQQSLLNIAC SVKSRTRNIV YSRSSRDQPL
SLSILGGKEN GSSGVFVSDV QRGSRAEKIG LKRGDQIIEV NGQSFKKISL IRALEVLRSN
THLSMTVKSN LLGFKEMIAR SERAVDVEDQ CNAYCKGPDI RYTKHRVASK QNENGQRGSM
SCMIGMNPRS GASSFSCLPP SGMTSSAGNK TSMMDKLLTM LKGLPSTLPD GPVTEPKALN
PTRSNSLRAS RSNPDIAGHS VGASRISTMN IAQYYQPTSS PCPEHVLKVY RADQSFKYLT
VYRETTAQNV VQLALQEFGM SSDSGSLEWA LCETTVTPDG VIKQKRLPDQ MNNLAERIQL
NSRYYLKNNS RSEPLVPDEL APEVLKEAET HLLQLNAQIL AAQLTLQDFD VFSAIEPTEY
VDNLFNLESK YGWPKLADFE SLFNKEMWWV ATEICREKGL QKRMKLIKKF IKIARYCRDF
RNFNSMFAIM SGLEKPAVRR LHHTWERVPS KYMKMFEDVQ HLVDPSRNMS KYRQHLAIVS
QEPPVVPIYP VLKKDLTFSH EGNPTYCEKL INFEKLRMIA KAIRSVTKLC SSPYEIGVMA
QQSGGNDVSD AL
//
