ID   A0A0R3RYN8_9BILA        Unreviewed;       544 AA.
AC   A0A0R3RYN8;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE            Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE            Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE   AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
OS   Elaeophora elaphi.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX   NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000740001-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:EEL_0000740001-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC       Nucleus {ECO:0000256|RuleBase:RU361195}.
CC   -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC       {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR   AlphaFoldDB; A0A0R3RYN8; -.
DR   STRING; 1147741.A0A0R3RYN8; -.
DR   WBParaSite; EEL_0000740001-mRNA-1; EEL_0000740001-mRNA-1; EEL_0000740001.
DR   Proteomes; UP000050640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009791; P:post-embryonic development; IEA:UniProt.
DR   GO; GO:0050793; P:regulation of developmental process; IEA:UniProt.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0051239; P:regulation of multicellular organismal process; IEA:UniProt.
DR   Gene3D; 2.60.200.10; -; 1.
DR   Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR   InterPro; IPR013790; Dwarfin.
DR   InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR   InterPro; IPR013019; MAD_homology_MH1.
DR   InterPro; IPR017855; SMAD-like_dom_sf.
DR   InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   InterPro; IPR036578; SMAD_MH1_sf.
DR   PANTHER; PTHR13703:SF25; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG; 1.
DR   PANTHER; PTHR13703; SMAD; 1.
DR   Pfam; PF03165; MH1; 1.
DR   Pfam; PF03166; MH2; 1.
DR   SMART; SM00523; DWA; 1.
DR   SMART; SM00524; DWB; 1.
DR   SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   PROSITE; PS51075; MH1; 1.
DR   PROSITE; PS51076; MH2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU361195};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          69..198
FT                   /note="MH1"
FT                   /evidence="ECO:0000259|PROSITE:PS51075"
FT   DOMAIN          351..544
FT                   /note="MH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51076"
SQ   SEQUENCE   544 AA;  61216 MW;  D2A722883B2BF988 CRC64;
     MKGLFDIGTA SATVRRLVSM IREKPLGEET TNIELEWDRN LMELKQVKIK LRWIAAKWHK
     LNAVEFKWKC INEMYLRGIK LGRFEIGRDE HWPEKAVKSL VKKLKKSKAI DELEKAISTE
     DPNTDCVCIP RSLDGRLQVS QRKCLPHVIY CRMWRYPELA SSHQLKSVPH CRFPYSKKLE
     SVCVNPYHYE KVENPPLPAI LIPRNDNLNA IGSLSNVGDL SKALRTVYPT VDTNEMVTHG
     VPNRTVMSSD QTGWQNSHNS STLSSPVMNT PVGINAIGIV PLSPTENTIE NRLFSANTEA
     ISPRGYMSED LEMDEGQSPD SSQVLSPAYD SSIAERAMNL IAVEYCEPPF WCSVSYYELS
     ERVGETFHAS QPSLIVDGYT APSDAERFCL GQLSNVNRTA SVMEARKHIG RGARFYYIGS
     EVFCECLSDS AIFVQSPNCN QRHGWHPATV CKIPPNCNLK IFNNAEFAAL LAASVPQGFE
     AVYALTRMCT IRVSFVKGWG AEYRRQTITA TPCWVEAYLN GPLQWLDSVL KQMGSPPNRC
     TSFT
//