ID A0A0R3S2T4_9BILA Unreviewed; 924 AA.
AC A0A0R3S2T4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Protein vav {ECO:0000313|WBParaSite:EEL_0000904401-mRNA-1};
OS Elaeophora elaphi.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000904401-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EEL_0000904401-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
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DR AlphaFoldDB; A0A0R3S2T4; -.
DR STRING; 1147741.A0A0R3S2T4; -.
DR WBParaSite; EEL_0000904401-mRNA-1; EEL_0000904401-mRNA-1; EEL_0000904401.
DR Proteomes; UP000050640; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20810; C1_VAV; 1.
DR CDD; cd21201; CH_VAV; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd09940; SH2_Vav_family; 1.
DR CDD; cd00174; SH3; 2.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035031; Vav_SH2_invertebrate.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR PANTHER; PTHR45818:SF3; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 5..123
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 215..406
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 439..555
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 566..614
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 637..699
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 773..863
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 868..924
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 924 AA; 106455 MW; 9EBB9B7ADFB263D4 CRC64;
MAESSELWRE CVRWMNECGI LDAKHRVAEA DAEIGEFATI LRDGVLLCLL CNRLCENCID
VKDLQQRPQM AQFLCCKNIC EFLKACKNTF EMKPEDLFDP WDLYRLDDFG KVLRTLSKLS
MSPVAKLSGV RGFPSRISSL NSAEYYNDKV IYKNLRQGAE VNEPVLENAY DVGIAEEEKT
SGRIYDSIVC QRSNSQRELK AIEYDKWINF KPDSRREHCV KELYDTESNY VEKALDMIIN
NFYTPLEEVL SKDDHKMIFM NILELACIHR SFRDHLRQAV FYTVGLEEPT NDEKPVTIGD
VFITWKEKFV AYGEYCSKLP NSRSRICYLE KTDPVVRQKI IDCGIAANRN QFHLQDLLSI
PMQRVLKYHV LLSEMIKLTA VDSVDRLPLE EAKEAMQDIN SYVNEMKRDY EMQQLVMDVE
NSITDLELPV GMHLINYGRL VKDGEIKIAD QSKDGNRLKT RYVFVFDKVM IICKSLRGNQ
YSYRSAHILN DYRIGVDADN NNKIGTITRK LTANGGYYFS LVQELDDNVT NVLNICCKTM
LQRDSWVQNI MAAQGNVRPK DSEASGHCLQ YHSYDKATVC FHCEKLLAGL FYQGYHCSDC
KRNLHRSCLS MSKCPGVGLI LTRSQAPNRR KHTSSLQPHE CVRAVQSFHS NDPLFLSFEM
NDLIEIIQRN ADGTLMGRIV AFPNRTGLVQ PEFVRRFRIS TSSLHMGSST CTSNSITLSS
PVEHSDSWIS STQLQLPLAN SERRSSASIE NMFLPRKLQS QDYVNTEVMG QQWYRGPMKR
WDAEVLLRGT PDGTFLLRFS ATQQKYVISI SFNGDVKHTK VEQSPEGRFY LDESTMFASI
VELINYYREN NLRESFETLN TTLRHSYTDK QSYVALHNFE ASEPNFLTLV VGQRVYVISR
TGEDRGWWKG RSGNRVSHHL NQFL
//
