ID   A0A0R3S4E7_9BILA        Unreviewed;       640 AA.
AC   A0A0R3S4E7;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
OS   Elaeophora elaphi.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX   NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000966601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:EEL_0000966601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000256|ARBA:ARBA00007878}.
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DR   AlphaFoldDB; A0A0R3S4E7; -.
DR   STRING; 1147741.A0A0R3S4E7; -.
DR   WBParaSite; EEL_0000966601-mRNA-1; EEL_0000966601-mRNA-1; EEL_0000966601.
DR   Proteomes; UP000050640; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   CDD; cd11558; W2_eIF2B_epsilon; 1.
DR   Gene3D; 1.25.40.180; -; 1.
DR   Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   InterPro; IPR003307; W2_domain.
DR   InterPro; IPR044123; W2_eIF2B_epsilon.
DR   PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT   DOMAIN          476..640
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
SQ   SEQUENCE   640 AA;  73102 MW;  DC06A75304F98A72 CRC64;
     MGRKENKADT SETKEEPFKV LIIADTFDAR FLPITSDSSI SCVRIANIGI LHHMLEWISR
     TELRDVIIAL SSHPEGAIQR IINYWRMLFD SFVVILCQNC MSIGDALREV HSRCVIKSDF
     LLLTTPMTIA ATDLSAQISS FKEIRKDKNN VMLVIYGEWK NKCPVIAYEK KSGRLIFYHQ
     KDDASKLDVD KDVFAADSVV CNNLRDTGIT FCSLNVLVQF SDNFDFQCKD DLIREILVNE
     EILSQKIYVS ILPKQIPAFC AHDYSDLLLM NKLLLQRFFF PLVPDNNSYS TYICRRNNIY
     TPSDNLQPNH EPKRTLPSIC DGANVLLGKN CSIGLDVVLK NVSIGSDTSI GDGCEIVDCI
     IGRGVSIGTK THLSECYIAD DVIIGDNVIL LPRCIVSSKV IIRDGKKLPS GSVISTEHYE
     DDHEQFECIP SEYGFEWRMK NGRDFWHTTC SNLQLRGTAM ISTDVDDSKE TEQAVGEKEM
     DNVDRFYDEV KESMDRIAEH KEYNEQLIKN LILEINSSKL AYNITMEDVA RNVFLSFLSL
     SDTFSELKKL AKNWHSLFIN YYKPIKSQIQ ALIAVEEFLS SKPNFKLLAA KVIHFFYEED
     IFEEDAILEW YDTVHENATI KTLVRPIIDW LQDTTEESDD
//