ID A0A0R3S8W0_HYMDI Unreviewed; 1680 AA.
AC A0A0R3S8W0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=HDID_LOCUS623 {ECO:0000313|EMBL:VDL17052.1},
GN WMSIL1_LOCUS12269 {ECO:0000313|EMBL:VUZ54138.1};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000062201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0000062201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL17052.1, ECO:0000313|Proteomes:UP000274504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:VUZ54138.1, ECO:0000313|Proteomes:UP000321570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WMS-il1 {ECO:0000313|EMBL:VUZ54138.1,
RC ECO:0000313|Proteomes:UP000321570};
RA Jastrzebski P J., Paukszto L., Jastrzebski P J.;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; UYSG01000084; VDL17052.1; -; Genomic_DNA.
DR EMBL; CABIJS010000610; VUZ54138.1; -; Genomic_DNA.
DR STRING; 6216.A0A0R3S8W0; -.
DR WBParaSite; HDID_0000062201-mRNA-1; HDID_0000062201-mRNA-1; HDID_0000062201.
DR Proteomes; UP000046397; Unplaced.
DR Proteomes; UP000274504; Unassembled WGS sequence.
DR Proteomes; UP000321570; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 4.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000274504};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 331..354
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
FT REPEAT 537..683
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 686..828
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 833..972
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 979..1124
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 1128..1269
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 1274..1420
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
FT REPEAT 1423..1568
FT /note="CHCR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01006"
SQ SEQUENCE 1680 AA; 191426 MW; B3BE1765A1E11281 CRC64;
MSASMPIKFQ EHLQLVNVGV QPASISFNTL TMESDKFICV REKKGDGQYV FIIDMNDPNN
PTTRPITADS IIMNPVSKVM ALKSEGVLQI FNIELRTKMN MYKMTEPVIF WKWINPNTIA
LVTAGSVYHW SIEEGSTPVK MFDRHGSLAN TQIINYRTDE SCKWLLLIGI SVQDSRVVGS
MQLYSVDRKV SQPIEGHTAA FVQYKGEGQP NPTTLFCFAA RSAQSCNLHI IEVGQSPEGN
QPFAKKNLDV YFPPEAVNDF PVAMQASQKY AVVFLITKNG YLHIYDIESG TCIYMNRVSN
ETIFVTVPYE ATSGIMGVNR KGQVLSVSID EDNVINYIKG TLNNPTLAFR FAARCGLPGA
DDLFIKRFES LFAAGQYAEA AKVAASAPNG ILRTPKTIQK FHQIPNQAGQ TSPLFLYFGI
LIDQGQLNKY ESLELCRPVL QQARKHLIEK WLKEDKLECS EELGDLVKQA DPTLALSVYL
RANVPPKVVQ CFAETGQFQK IILYSKKVNY SPEYISLLRN LTRINPDQAL QFAQMLVQDQ
EPLVDLEQVV NVFTEQGLIQ QCTSFLLDAL KHNRPSEGHL QTRLLEMNLM SAPQVADAIL
GNQMFTHYDR AAIAQLCEKA GLLQRALEHY TDLYDIKRAV VNTHLLTPEW LVKYFGSLSV
EDSLECLKAM LQANIRQNLQ VCVQIATQYH EQLGTNALIE IFESFKSFEG LFYFLGSIVN
FSQDPEVHFK YIQAACKTGQ VKEVERICRE SNYYDPERVK NFLKEAKLTD QLPLIIVCDR
FDFVHDLVLY LYRNNLQKYI EIYVQKVNPA RLPAVIGGLL DVDCADDFIK QLIAVVRGQF
STDELVAEVE KRNRLKLLLP WLESRIHEGS VEPATHNALA KIYIDANNNP ERFLRENQYY
DSYVVGKYCE KRDPNLACVA YERGQCDKEL VAVCNENSLF KTEARYLVRR KDPELWAECL
SETNTYRRQL IDQVVQAALS ETQDPDEISV AVKAFMAADM PNELIELLEK IVLDNSVFSD
HRNLQNLLIL TAIKADHSKV MEYISKLDNY DAPDVANIAI THGLYEEAFA IFKKFEVNNL
AMKVLIDNIQ NLDRAYEYAE RCNEPAVWSL LAKAQLNEGV IKEAIDSYIK AGDPANYDEV
IKAASAANNY EDLVRYLQMA RKKARETTID SELAFAFART GRLSDLEEFI ASSNHANITS
VADRCFEEHM YEPAKLLYNN VSNYSRLAIT LVHLGEYQGA VEAARKANST RTWKEVCFAC
VDHGEFRLAQ MCGLNIVVHA DELEELIKYY QQRGHFQQLI TLLEAALGLE RAHMGMFTEL
AILYSKFKQE KLREHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDRYEE YDNAVQTMMA
HPTEAWRENH FKDMITKVAN LELYYKAIQF YLNYKPLLLN DLLTVLIPRL DHTRTVAFFT
KNGHIAFIKP YLCVVQQSGA NNKSVNEALN ALLIEEEDYQ ALRQSIEAHT NFDNIALAQA
LEKHELTEFR RLSALLYKGN NRWVQSIELC KRDKLYRDAM QYAADSRDPE TAEDLLRWFL
SENLPDCFAA CLYQCYDLLR PDVVLELAWR NGLTDMAMPF LIQTMRELTT KIDHLEKSER
TRTEEEEKKE QAVNPLVLHT DAPLMLTSGM MGTQSGAYGG SMIPPGGPGN TFYPTNGPSY
//