ID A0A0R3SAK6_HYMDI Unreviewed; 640 AA.
AC A0A0R3SAK6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Phosphatidylinositol-3-phosphate phosphatase {ECO:0000256|ARBA:ARBA00031219};
GN ORFNames=HDID_LOCUS1391 {ECO:0000313|EMBL:VDL18852.1},
GN WMSIL1_LOCUS14340 {ECO:0000313|EMBL:VUZ56812.1};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000139001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0000139001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL18852.1, ECO:0000313|Proteomes:UP000274504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:VUZ56812.1, ECO:0000313|Proteomes:UP000321570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WMS-il1 {ECO:0000313|EMBL:VUZ56812.1,
RC ECO:0000313|Proteomes:UP000321570};
RA Jastrzebski P J., Paukszto L., Jastrzebski P J.;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; UYSG01000253; VDL18852.1; -; Genomic_DNA.
DR EMBL; CABIJS010000708; VUZ56812.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R3SAK6; -.
DR STRING; 6216.A0A0R3SAK6; -.
DR WBParaSite; HDID_0000139001-mRNA-1; HDID_0000139001-mRNA-1; HDID_0000139001.
DR Proteomes; UP000046397; Unplaced.
DR Proteomes; UP000274504; Unassembled WGS sequence.
DR Proteomes; UP000321570; Unassembled WGS sequence.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF8; PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000274504}.
FT DOMAIN 137..538
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT REGION 570..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 353
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
SQ SEQUENCE 640 AA; 72326 MW; F675BDC125817173 CRC64;
MVQRTAFAAE ELIAKYDNCR CLGVDGSYGI IELTNYRLSF ISHGGLRSTL YSVPLTTIQS
IELKRSFRTD QVTQQTGLFL FCKDMRQLRF VLPSASIRDD MAKYITEVIR PTYRTRPLFA
YIFAEVCLAK GLYLESGWNI YSPEDEYHRQ NVVNNGWRIS KVNEGYKLCR TYPEVLVVPV
KVSDDILVRC APHRARGRLP VLSWLHPESR ASLTRAAQPL TGPSARRNEA DEELVRDIRD
ANANTVNLLV FDVRPQFTAV VNRGRGGGVE NPAFYTNIQY SFMNIPNLHA MRASFTKLMT
AVTSVTLAQQ DGAQWLKTIH ETKWLYNTQQ ILSAAAAVAD QIENHKSSVL VHCSDGWDLT
PQVTSLAMLM LDPYYRTLKG FQVLIEKEWI SFGHKFCQRT GGPADGGNLV FPHIPPSNTS
IKVEVSSLEE RSPIFLQFID CVWQMMTQFP ASFEFNETFL ITILDELYAC RFGTFLFDSE
CEARNNLARN KTISLWGYIN SNTRAYLNPT YTPAEVSGHR LIIPCAMSYQ LELWKSYYLR
WQPFMRCQEP VVSHSAMVLE RMQKFRALSR QNKRLQDEDG NVEGTSAGSS ASSLPLGGKR
DTPDAGINLP TVQSAVSPRR IFPRFPISGA AGGITLEKAS
//