ID A0A0R3SBS6_HYMDI Unreviewed; 1582 AA.
AC A0A0R3SBS6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=tryptophan--tRNA ligase {ECO:0000256|ARBA:ARBA00013161};
DE EC=6.1.1.2 {ECO:0000256|ARBA:ARBA00013161};
DE AltName: Full=Tryptophanyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030268};
GN ORFNames=HDID_LOCUS1962 {ECO:0000313|EMBL:VDL19423.1};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000196101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0000196101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL19423.1, ECO:0000313|Proteomes:UP000274504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594}.
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DR EMBL; UYSG01000424; VDL19423.1; -; Genomic_DNA.
DR STRING; 6216.A0A0R3SBS6; -.
DR WBParaSite; HDID_0000196101-mRNA-1; HDID_0000196101-mRNA-1; HDID_0000196101.
DR Proteomes; UP000046397; Unplaced.
DR Proteomes; UP000274504; Unassembled WGS sequence.
DR GO; GO:0001401; C:SAM complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004830; F:tryptophan-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006436; P:tryptophanyl-tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002305; aa-tRNA-synth_Ic.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR024790; APC4_long_dom.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR InterPro; IPR002306; Trp-tRNA-ligase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR NCBIfam; TIGR00233; trpS; 1.
DR PANTHER; PTHR43766; TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43766:SF1; TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL; 1.
DR Pfam; PF12896; ANAPC4; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF10568; Tom37; 1.
DR Pfam; PF00579; tRNA-synt_1b; 1.
DR PRINTS; PR01039; TRNASYNTHTRP.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000274504};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1542..1562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..144
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 259..345
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 460..646
FT /note="Anaphase-promoting complex subunit 4 long"
FT /evidence="ECO:0000259|Pfam:PF12896"
FT REGION 1011..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1582 AA; 178952 MW; 548369B35E25F669 CRC64;
MSSVEIVSTP EDFSLPNDQA TLLACLKYLK LKMYDYNVRY SRNAFFASPD GLLPVSNING
NLVSGYMSMV FNLKSFRNDP EIETDAAVLE RKNIHHIFFF WVADVLRNLT LYLTWIESSG
ERCTRNHFAS IYPWPLSIYY FNRQQKLIVK YLKSSTGWAA EDTGEVLNRF DAACKNISSM
LTEGHYMFNR TKAGKVDCLV AAYFRTFSAF PKYFSCLAPI ISKYPYITNL AAIMAMTQEY
STMIYKEKPI SRTRVSVAAW SPTMDIIALG SPTGIVSLHK YKMGVNWEVT SQDSGGVTHI
AWRPDGDVLA VAYESGRVQQ LNHSDGSIVY AMEFGYKAIE HLSWVSCEHE VAKKEAFFPS
FSSLSVFSDE IFSNRNEVNQ LSQPWIHVDS KPSILAIQFA DHTIRLFGCG FYEVLAFRLD
SFHKIYECSM AHDFSSFSFF SLNQRGSLQL NRGPSPALAE HCLPLQRVSY HVANLLHCKN
ILNWCLKQLQ GFWESTLVEL DSKLTTYSRM RLENSPEWSL RNELMEVILF GHVSIELKEY
FKRHWPPTAI RRTGIAMFKA YDGMQAVAFQ QLQFILVRLI CEASELLGCI RDHQNLECFG
LKEEAVVELV QAVGTALQKT HELHTIVKYC SQYLRPFFHW LYEVADSSIK DMLRRVDVNI
SQAELSLVIT FITERFTPCF INGQLKSYQI ELVEQYIRRG GITKPLDLVM GFKASEEHFK
RTKLKNLIPL HGSLDKRFFP DGIFFTSTCS LADLIEIQLA ECINKVATFG EVVSPVGLFQ
EPEPPIPLIN HVSDISKYHL CSTSHQITST PTNKSIQALG IQICAGTVDR FAFVRPRKDL
GNRDTIFVYS VDPSRTYNIV DMKFFGMSTL AVVLTREDDV SSNMTLQWIV FIPLDESIAA
ASALPPISLL PASTTLSDYL AGSSVPLSKL VTQQLQVHTL PYKPYWFTLN EKHVRFFLSG
FHNETQRNFE CSVDDRLFPQ SSLIYSTFPM SCDITRVFAC TVRALATGPI SHKPSATSSD
QTEEAQSTAK STTSNSFASR AQSLFTELVT VRKHLNHAGE LSYDLATNDL TRQRMYHEVA
KEINGTLDKC DELLKQLQRR CRGVKQGEEK GQGTEHRKAV CRSLEEFLKT LQRIRDDQVS
TYCRRVELAS RLGDTPISPS TFQQEISSVS DGVRKRVSGS DTSWLFGNLS SHSVDALSPD
SLSETEFKQL EMENAEIYLR FISERNEVQR LGSQITEISR LQSMVTESLV EQAEARFDTH
LSCLRHAKLL QVTVQYSTRT ASKTVVTGIQ PTGFPHLGNY YGMIKPCVKL QDDQNTENFF
LLIADLHALT KHARDDDLTR STLQLAGALM ACGIDPVVSS DGKHCKGKTI LFPQSNIVGH
CELSWILSTK CTVNRLAHLP QWREKSEAAG ESGGSVGLFT YPLLQSADVL LYSADAVPVG
IDQVTHLELT RDIARTLLTQ WPSLNSFLKV PDIQLTEIPK IHNLREPTMK MSKSIGPESG
TIWLMDTPDE IRLKVSRAQT DSKRELSYDP LSRPGVANLM QIYAASNASS TMYIYIYIYY
IYIYSTYYLR VNAVFCSGNS DC
//
