ID A0A0R3SD20_HYMDI Unreviewed; 700 AA.
AC A0A0R3SD20;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Forkhead box protein O {ECO:0000256|ARBA:ARBA00039893};
GN ORFNames=HDID_LOCUS2540 {ECO:0000313|EMBL:VDL20001.1},
GN WMSIL1_LOCUS2434 {ECO:0000313|EMBL:VUZ41724.1};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000253901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0000253901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL20001.1, ECO:0000313|Proteomes:UP000274504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:VUZ41724.1, ECO:0000313|Proteomes:UP000321570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WMS-il1 {ECO:0000313|EMBL:VUZ41724.1,
RC ECO:0000313|Proteomes:UP000321570};
RA Jastrzebski P J., Paukszto L., Jastrzebski P J.;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-
CC ProRule:PRU00089}.
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DR EMBL; UYSG01000637; VDL20001.1; -; Genomic_DNA.
DR EMBL; CABIJS010000066; VUZ41724.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R3SD20; -.
DR STRING; 6216.A0A0R3SD20; -.
DR WBParaSite; HDID_0000253901-mRNA-1; HDID_0000253901-mRNA-1; HDID_0000253901.
DR Proteomes; UP000046397; Unplaced.
DR Proteomes; UP000274504; Unassembled WGS sequence.
DR Proteomes; UP000321570; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20032; FH_FOXO; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45767; FORKHEAD BOX PROTEIN O; 1.
DR PANTHER; PTHR45767:SF2; FORKHEAD BOX PROTEIN O; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000274504}.
FT DOMAIN 239..329
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 239..329
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 80..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 73685 MW; 08E09708440D1DFD CRC64;
MSDLFRCRAS TWSAGAVPDH HDHDPDQPRI GGFDYGDCAA SVSAAAAAAL ALHSANASGS
PIDPVPGNTG TGGFHYSPTD LTSQEFSNNS RRHPMLEKTP SETASDYAQN FFTSSPPPRS
SRDWNTSGTF AQSNFSVLSV TANSPFGGHH ADNSGSLLTP YGNSSPYTNG QQQQQQTSQP
GLHSGSPSSV GSQLSNMMSG GLSANTPTTT PTTQSSGNGG TSGSAAKRPA RRNPWGSETY
SDLIAKAIES YPDKQATLQQ IYDYISTNYT YFRERSDPPA SAGWKNSIRH NLSLHDKFVK
CPKASESSKS SYWRLNANSL NRPYVRRRTC SLDTPGNGGN GSVGGKKAKS RLGSSGAALV
GNSGSNTVSA GKRSAAQMGG RDMKTGIYGD DLSAAAVRSH LNSLSSGITS AFSIPGGAGG
GATGLKGDPS GGLNHHHNPW ANSGFLTDRK MANDELSALC KMHTSDPISS NSLSGGGLGG
GSGYEFQMPR VPPSSSTRSS FSSSGIGSER GSSSFFSPPP PLQPPTSTTN RYHLPHPCQH
FSHDQQGRYN NSNVCETSPN PNQPNSNTYD QLTGVLTGSA ECLEGGSDDP FIREEAHQLM
GHHHHHHVQH HPAGPQTNSH LHNLLMSGAG GDSAVNSSDM SSAQHHQLSQ QQSHLSSQDD
MELRISLEIA NRVKSGEMNS TMQQWAAAAA SAARTVENGV
//
