ID   A0A0R3SGC0_HYMDI        Unreviewed;      1265 AA.
AC   A0A0R3SGC0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=PINc domain-containing protein {ECO:0000313|WBParaSite:HDID_0000393801-mRNA-1};
GN   ORFNames=HDID_LOCUS3936 {ECO:0000313|EMBL:VDL41227.1};
OS   Hymenolepis diminuta (Rat tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX   NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000393801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HDID_0000393801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL41227.1, ECO:0000313|Proteomes:UP000274504}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYSG01001331; VDL41227.1; -; Genomic_DNA.
DR   STRING; 6216.A0A0R3SGC0; -.
DR   WBParaSite; HDID_0000393801-mRNA-1; HDID_0000393801-mRNA-1; HDID_0000393801.
DR   Proteomes; UP000046397; Unplaced.
DR   Proteomes; UP000274504; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   CDD; cd09885; PIN_Smg6-like; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR   InterPro; IPR019458; Est1-like_N.
DR   InterPro; IPR045153; Est1/Ebs1-like.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR   PANTHER; PTHR15696:SF40; TELOMERASE-BINDING PROTEIN EST1A; 1.
DR   Pfam; PF10374; EST1; 1.
DR   Pfam; PF10373; EST1_DNA_bind; 1.
DR   Pfam; PF13638; PIN_4; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274504}.
FT   DOMAIN          298..424
FT                   /note="Telomerase activating protein Est1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10374"
FT   DOMAIN          433..762
FT                   /note="DNA/RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF10373"
FT   DOMAIN          1003..1209
FT                   /note="PIN"
FT                   /evidence="ECO:0000259|Pfam:PF13638"
FT   REGION          20..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          572..595
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          903..952
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1242..1265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..149
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        903..938
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1265 AA;  143904 MW;  4BE62108BE72255D CRC64;
     MSYRGRRGYR SVYQSSLNNI SENNPINYLT DTQKSSNSRS RGGGNARGFS RNNARDHIDQ
     RDRIISDLES NSFNTTTCNG PRRQINSDVV ANIQSYIQED RQVSGNSTIK QGGIIQIPKE
     VNIYDQIVIN DDDDTSVNHK RESHSKPVQV VRPHQRKSNH LNSDSRPSYR ATKPAKQGGG
     RGAMKQSANI STESDFPLLR QSIQQQPRIS RNPIVGESAV NILTYFNALN TLMEPPGVCA
     PHMPPLSDET SEEKSALSKA ELLFIRWWFS IKKLRENLFA CFETLVLHDL NFCFEGQVEL
     ELWKAIFYNL IELMRGWIDN PFDTELLSVP TEGADKLRID FDACENLVKL IKKTLLEDVI
     ESGIKRYTEL LGRLQQVYRI PLDYLLAEGR PAPDSNSRTV ILFYLCSQKI SLFLGDLARY
     AESINNTQNF GIARSWYLKA QLIYPKNGRV YNQLGFLSIK MGRPLDAMCY YMRAAAASNP
     FQTAVQTLLA LFHEHEDHWN KWARNNPLKG QFHLGTKTKE AKTANEAAHF VAEGMKNKIE
     IWYHPLNNVV TIVMGMNSLV VPRALLQQRM KEARARRSRS NSSGSLVSEE ESEEAQADAE
     EYANIPLLKL TKTFSLYFMH THGLLFTKIG METFPDVAST ALQALSGLLA QEPCAINCDR
     LYQILMSNMF NLDRASSLST ALKSTTMTEL EPTRSVYHDH AARFALDTFS LICRRATKLF
     SESKGGSPDS EGWLHPDLKV LLLGLRLWTE WMILHPEHWS PPPKYRDPVL RPHLDEWRLV
     ADLCTAAAKW ISKVKNAPTV EEITPTNDLV VQNYLRKQAE QTPPLEGPKY GTLFEETVFA
     GFKPMLDLTP KLYQYTGDWD PESVEQFIRI EKMVLFGDFL CGIETPVLSF DVDSGVYLKA
     VPEEPNKSEK PQIDGGIEQE EKNEESVSNE KTSDENQEPY KDTEDDQEDV GDEEFQALRK
     KRDELRARIE NKNRLAEWRA KAEKRTAAGH SRAVEIEVRP VYIVPDTNCY IDWLEGIARL
     AQASSNYTLL VPIIVFNELQ YLASKARQQS LHPIENAFSE YLVNPTSNTK KGDIIQDRAK
     AAIIYLEGEF ERRNPRLRAI TAQGNILETI AYRNELDTRQ VDQNNDDVIL DCCRHLCKEP
     LGRKVVNVPS QSKMNSMFVC LIDITSVCDM ILNTHLPNFT DQPLVLTRQV VLLTGDRTLR
     IKARSAYVPV TPLRPFVMWS NLKPVALPRE VEELISHALP SDQKVSEGLE SEKKTTRKNR
     GGRQK
//