ID A0A0R3SH62_HYMDI Unreviewed; 470 AA.
AC A0A0R3SH62;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Acetyl-CoA hydrolase {ECO:0000256|ARBA:ARBA00017958};
DE EC=3.1.2.1 {ECO:0000256|ARBA:ARBA00011920};
DE AltName: Full=Acetyl-CoA deacylase {ECO:0000256|ARBA:ARBA00029672};
GN ORFNames=HDID_LOCUS4276 {ECO:0000313|EMBL:VDL46702.1},
GN WMSIL1_LOCUS9098 {ECO:0000313|EMBL:VUZ50117.1};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000427601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0000427601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL46702.1, ECO:0000313|Proteomes:UP000274504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:VUZ50117.1, ECO:0000313|Proteomes:UP000321570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WMS-il1 {ECO:0000313|EMBL:VUZ50117.1,
RC ECO:0000313|Proteomes:UP000321570};
RA Jastrzebski P J., Paukszto L., Jastrzebski P J.;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O = acetate + CoA + H(+); Xref=Rhea:RHEA:20289,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=3.1.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001831};
CC -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family.
CC {ECO:0000256|ARBA:ARBA00009632}.
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DR EMBL; UYSG01001574; VDL46702.1; -; Genomic_DNA.
DR EMBL; CABIJS010000344; VUZ50117.1; -; Genomic_DNA.
DR STRING; 6216.A0A0R3SH62; -.
DR WBParaSite; HDID_0000427601-mRNA-1; HDID_0000427601-mRNA-1; HDID_0000427601.
DR Proteomes; UP000046397; Unplaced.
DR Proteomes; UP000274504; Unassembled WGS sequence.
DR Proteomes; UP000321570; Unassembled WGS sequence.
DR GO; GO:0008775; F:acetate CoA-transferase activity; IEA:InterPro.
DR GO; GO:0003986; F:acetyl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006083; P:acetate metabolic process; IEA:InterPro.
DR Gene3D; 3.30.750.70; 4-hydroxybutyrate coenzyme like domains; 1.
DR Gene3D; 3.40.1080.20; Acetyl-CoA hydrolase/transferase C-terminal domain; 1.
DR Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR InterPro; IPR026888; AcetylCoA_hyd_C.
DR InterPro; IPR038460; AcetylCoA_hyd_C_sf.
DR InterPro; IPR046433; ActCoA_hydro.
DR InterPro; IPR003702; ActCoA_hydro_N.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR21432:SF20; ACETYL-COA HYDROLASE; 1.
DR PANTHER; PTHR21432; ACETYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF13336; AcetylCoA_hyd_C; 1.
DR Pfam; PF02550; AcetylCoA_hydro; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000274504}.
FT DOMAIN 39..211
FT /note="Acetyl-CoA hydrolase/transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02550"
FT DOMAIN 305..459
FT /note="Acetyl-CoA hydrolase/transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13336"
SQ SEQUENCE 470 AA; 51711 MW; 4A5EC58A9548E906 CRC64;
MKSMLTYRSF PRLFSQILSA RAIHGLREPT CPTPNRVPKA VTDPNELFKD LKSGQNVFIQ
GGAMTPTHLV KYLYQYAIDK DLKKLKTVHI HTEGEFPVNN EDVKERFRSV SLFTGGNCRK
AIESGQGDYV PIFLHEIPKI FRKKIFPLHY ALINVSPPDL HGFCSIGCSV DVTRSALEAA
DVIIAQINPH VPLCNGDAEI HVSNIDYTID GPMPLHEMPV RQSSAEEKKI AEFIANELVA
DGATLQTGIG SIPDSVLSLL VKHKDLGVHT ELFSDGLVDL FQSGAVTNAK KKHFPGKIVS
SFVIGTKKSF DFVNDNKGLD MRDIAWTNNP IVISQNPRPT AINSCIEIDI TGQIVSDSIG
SRIYSGFGGQ VDFLRGAAIA TDGLGVPIVA LQSATKKGQS KIVPYLQKGA GVVTTRAHAH
YVVTEYGIAY LFGKSIRQRA YDLIRIAHPN HREQLEKDAF ERLKVMPSAD
//
