ID A0A0R3SQM8_HYMDI Unreviewed; 797 AA.
AC A0A0R3SQM8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Dual specificity protein phosphatase {ECO:0000313|WBParaSite:HDID_0000738901-mRNA-1};
GN ORFNames=HDID_LOCUS7387 {ECO:0000313|EMBL:VDL59705.1};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000738901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0000738901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL59705.1, ECO:0000313|Proteomes:UP000274504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily.
CC {ECO:0000256|ARBA:ARBA00008601}.
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DR EMBL; UYSG01010930; VDL59705.1; -; Genomic_DNA.
DR STRING; 6216.A0A0R3SQM8; -.
DR WBParaSite; HDID_0000738901-mRNA-1; HDID_0000738901-mRNA-1; HDID_0000738901.
DR Proteomes; UP000046397; Unplaced.
DR Proteomes; UP000274504; Unassembled WGS sequence.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR10159; DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR10159:SF540; TYROSINE-PROTEIN PHOSPHATASE VHP-1; 1.
DR Pfam; PF00782; DSPc; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000274504}.
FT DOMAIN 18..134
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 338..487
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 407..466
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 174..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..688
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 85792 MW; 12968377480E66AA CRC64;
MYEIPSVTVH QLAPWLFHKE QVAVLDIRSF REYHTSHICS ALNLGGNRAF KRRLLAHRNA
LAPFIALLVG VSVENLRKFT KIVLYDQNSA EQPFLYSDNF TQFVISGTAE LFPNAVLLQG
GFVGFCAAYP QLCWQHPDKL PDEEFVGVKG DSGLENLLQE CLYKLYHEIP PSNPLSPGER
SNISTRQPSS CSSCGSSSSQ QSCDSGVVLS AADSASSTLM LNRKAISRVT SAPIKRPTTV
VASLSVDDAI MAGSSSRRPS RLRPNTLSLC SPSFSTSATS AAVNTLTNNI MDRPSRCTFA
SSFRFLSTPP PSTSSLQSSR PASTVSAALS AEAFESPLPT AVLPHLLIGC QADAMSAEVC
SDFGVTHVIN VSADGEMSPH VSPCRFLRIP IHDNGKADIV QYFDKAFAFL GKAALYLYSA
KRSGGRVLIH CFAGISRSPT LAIAYLMHNQ RITFDEAYNR VKSLRPKISP NFNFIGQLTD
FEHRLNLSSL PSATSAVEVN RVPPVIIVPT VSPTQAATPP ENNVPENTPR IMRQASTCCA
SVVTVSTMTI PASATTSGPV RPVSLSLRRP SLKPLAVVAS KKRDRTQYLS PNSVFFSSSD
NSSPGDDETS ATYHVSNTTP TLLDAKTSTS QSTFVAHRKR SRFGPLLPSP STAIASLDLS
SPTEDQNLQS LNNFPSTPPP PPSPRPRRLR RPSPLRVDET RRFSLSTFSD FSRAALAACA
AAVTSSADAP SSDIDSEIDM AASNPTIISS GLHSPSAAHR WILGDSCRHQ QATAESSCHS
SLSSSSNSQH TPSFPIS
//
