ID   A0A0R3STS6_HYMDI        Unreviewed;       579 AA.
AC   A0A0R3STS6;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Amiloride-sensitive sodium channel {ECO:0000313|WBParaSite:HDID_0000883701-mRNA-1};
GN   ORFNames=HDID_LOCUS8835 {ECO:0000313|EMBL:VDL61153.1},
GN   WMSIL1_LOCUS10281 {ECO:0000313|EMBL:VUZ51578.1};
OS   Hymenolepis diminuta (Rat tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX   NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000883701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HDID_0000883701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL61153.1, ECO:0000313|Proteomes:UP000274504}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:VUZ51578.1, ECO:0000313|Proteomes:UP000321570}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WMS-il1 {ECO:0000313|EMBL:VUZ51578.1,
RC   ECO:0000313|Proteomes:UP000321570};
RA   Jastrzebski P J., Paukszto L., Jastrzebski P J.;
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR   EMBL; UYSG01011152; VDL61153.1; -; Genomic_DNA.
DR   EMBL; CABIJS010000444; VUZ51578.1; -; Genomic_DNA.
DR   STRING; 6216.A0A0R3STS6; -.
DR   WBParaSite; HDID_0000883701-mRNA-1; HDID_0000883701-mRNA-1; HDID_0000883701.
DR   Proteomes; UP000046397; Unplaced.
DR   Proteomes; UP000274504; Unassembled WGS sequence.
DR   Proteomes; UP000321570; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274504};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        29..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        505..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          558..579
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  66658 MW;  FE882BB03CCBAC1E CRC64;
     MPKESKFAIF CDLTSIRGVQ RIRRAQTPFI RIIWSIFVFL MTGALIITIG FLAKDFFSYT
     TAWNSRNLID DKTDFPAITI CAHNPFSLEA NRIWEKESIL TPSEFNRKLS AVVLAFVQSG
     NPDKATLLLH DTSETYFANL KPEESELLGH QANMFPHCML QSDGTNIMAE NCTIENDTGF
     IKQRFSHPKF FNCWTIETAP GKTSDDTSRL TLLLSLVPSK DINESRKNFV MDTFMRGEGV
     KVVVHQSGTY PEIDKDGINL QPGRMNELSY NTEYWVRLKT PKNPCVDNAP PITDMGRSYL
     YRFTQCLDSY LQNISINQCG CVNSEWPRPI NPSLVNTEIP YCSALLANTS DKSALTKMVD
     RYNCIYDLNV KVLKETAIKE RICIPHCSYY TYPISASIAS WNPIPEKLQL YTDKFKRVER
     LINNPNDQAE RERLIKYLKH VIKSEDGEHT KFNTTSTLQI EDFQNQAYYT YISLVRASKE
     TKYHEERLIF DIYILISRIG GLCSIFIGLT AAIFVELIEF IYVVYWQPRI DKVRENVRVE
     SHGDEQVLPL NKEHTDSIIQ SSNNNNNNNE NRNQKRCVV
//