ID A0A0R3SW37_HYMDI Unreviewed; 584 AA.
AC A0A0R3SW37;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Lysine--tRNA ligase {ECO:0000256|ARBA:ARBA00015745, ECO:0000256|RuleBase:RU003748};
DE EC=6.1.1.6 {ECO:0000256|ARBA:ARBA00013166, ECO:0000256|RuleBase:RU003748};
DE AltName: Full=Lysyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030563, ECO:0000256|RuleBase:RU003748};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000985301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0000985301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-
CC tRNA(Lys); Xref=Rhea:RHEA:20792, Rhea:RHEA-COMP:9696, Rhea:RHEA-
CC COMP:9697, ChEBI:CHEBI:30616, ChEBI:CHEBI:32551, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78529, ChEBI:CHEBI:456215; EC=6.1.1.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000204,
CC ECO:0000256|RuleBase:RU003748};
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00008226}.
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DR AlphaFoldDB; A0A0R3SW37; -.
DR STRING; 6216.A0A0R3SW37; -.
DR WBParaSite; HDID_0000985301-mRNA-1; HDID_0000985301-mRNA-1; HDID_0000985301.
DR Proteomes; UP000046397; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004824; F:lysine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006430; P:lysyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00775; LysRS_core; 1.
DR CDD; cd04322; LysRS_N; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_00252; Lys_tRNA_synth_class2; 1.
DR InterPro; IPR004364; Aa-tRNA-synt_II.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR002313; Lys-tRNA-ligase_II.
DR InterPro; IPR034762; Lys-tRNA-ligase_II_bac/euk.
DR InterPro; IPR044136; Lys-tRNA-ligase_II_N.
DR InterPro; IPR018149; Lys-tRNA-synth_II_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR NCBIfam; TIGR00499; lysS_bact; 1.
DR PANTHER; PTHR42918:SF9; LYSINE--TRNA LIGASE; 1.
DR PANTHER; PTHR42918; LYSYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00152; tRNA-synt_2; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR PIRSF; PIRSF039101; LysRS2; 1.
DR PRINTS; PR00982; TRNASYNTHLYS.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 225..551
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
FT COILED 8..35
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 584 AA; 66472 MW; 77259F9944787193 CRC64;
LNYLLISFSA LKKQLKAAER EKKKAEAASK QAANKPKVGA LKEEELDDQQ YYEMRLASIR
KLKEEGKINP YPHKFSASIS VPEFRKRYDH LEKGQHLNDV EVSIAGRLYS KRSSGTKLIF
YDLHSDMAKV QVMFTLHEYH DEEEFYEMGK IIHRGDVVGI VGKPCKTKLG ELSILPKKIV
LLAPCLQQLP HSHFGLKDKE TRHRQRHLDL IMNKDVVDRF YNRFKICKYL ENYLDSQGFL
GVETPTLTVL PGGAAAKPFI TYHNDLKMDL YLRIAPELYL KQLVVGGINR VYEKGKLFRN
EGIDLTHNPE FTSCEFYMAY ADYNDLVHMT EELLSGMVKM LFGSYKFTYQ PEPDMEPLEV
DFTPPFKQID LYEGLKEHYP GVEFPDPAEL HTEEARLKLV EIADKFNVQC GEPKTAARLL
DKLVGERIEP TCINPTFIMN HPEVMSPLAK WHRSRPGLTE RFEMFCLSKE LVNAYTELND
PEVQRQRFEE QARDKAAGDE EAMAIDEGFI QALSYGLPPT AGWGLGIDRL VMFLTNTNNI
REVIFFPTMK PEEGVTVAPG ISAIPGTAVA PPPDAAAAAS ISQK
//
