ID A0A0R3SWE8_HYMDI Unreviewed; 382 AA.
AC A0A0R3SWE8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00012980};
DE EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
GN ORFNames=HDID_LOCUS10001 {ECO:0000313|EMBL:VDL62494.1};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0001000301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0001000301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL62494.1, ECO:0000313|Proteomes:UP000274504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004992}.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776}.
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DR EMBL; UYSG01011478; VDL62494.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R3SWE8; -.
DR STRING; 6216.A0A0R3SWE8; -.
DR WBParaSite; HDID_0001000301-mRNA-1; HDID_0001000301-mRNA-1; HDID_0001000301.
DR Proteomes; UP000046397; Unplaced.
DR Proteomes; UP000274504; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR CDD; cd01672; TMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00165; Thymidylate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018094; Thymidylate_kinase.
DR NCBIfam; TIGR00041; DTMP_kinase; 1.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000274504}.
FT DOMAIN 176..342
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..36
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 382 AA; 43395 MW; 8ADB9DD29CA16E1A CRC64;
MPISKDKHYE YRDDHRRSSS KHHHHRKSHS STHRGKRSSS PPKMTLITSG EYAANSPLEI
KKDYRADLII TNGSVYAVKV EPVPIIDCIK LHRINPVIKP DVRVRESSIK KKSMAPYFIE
PVNLKKPFKE DRNAVVGSIC IDNDSTLIDD SIMSDGSNLT NKEEAMNSRK AVFIVLEGTD
RVGKSTQAKL LADALSAIYG NETYLIRFPD RTTTIGESLS NYLSGKVEIN PHAVHLLFTA
NRWERAADIE QALATGRCVV ADRYSYSGIV YTASKVHTHT PSWDWCLRSE EELPQPDIVL
CLLPDHIDDL ESRGGFGEER FENALFQTRV LNNYRRLAEE LKSKRANGNK ETPLWRWINV
KDANISEVHQ MILKEVEETA NT
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