ID   A0A0R3SWS8_HYMDI        Unreviewed;       688 AA.
AC   A0A0R3SWS8;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=DNA damage-binding protein 1 {ECO:0000256|ARBA:ARBA00014577, ECO:0000256|RuleBase:RU368023};
DE   AltName: Full=Damage-specific DNA-binding protein 1 {ECO:0000256|RuleBase:RU368023};
GN   ORFNames=HDID_LOCUS10153 {ECO:0000313|EMBL:VDL62790.1};
OS   Hymenolepis diminuta (Rat tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX   NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0001015501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HDID_0001015501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL62790.1, ECO:0000313|Proteomes:UP000274504}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of complexes involved in DNA repair and protein
CC       ubiquitination. May play a role in the regulation of the circadian
CC       clock. {ECO:0000256|RuleBase:RU368023}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|RuleBase:RU368023}.
CC   -!- SUBUNIT: Component of the UV-DDB complex.
CC       {ECO:0000256|RuleBase:RU368023}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU368023}.
CC   -!- DOMAIN: The core of the protein consists of three WD40 beta-propeller
CC       domains. {ECO:0000256|RuleBase:RU368023}.
CC   -!- SIMILARITY: Belongs to the DDB1 family.
CC       {ECO:0000256|RuleBase:RU368023}.
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DR   EMBL; UYSG01011547; VDL62790.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R3SWS8; -.
DR   STRING; 6216.A0A0R3SWS8; -.
DR   WBParaSite; HDID_0001015501-mRNA-1; HDID_0001015501-mRNA-1; HDID_0001015501.
DR   Proteomes; UP000046397; Unplaced.
DR   Proteomes; UP000274504; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR10644:SF3; DNA DAMAGE-BINDING PROTEIN 1; 1.
DR   PANTHER; PTHR10644; DNA REPAIR/RNA PROCESSING CPSF FAMILY; 1.
DR   Pfam; PF10433; MMS1_N; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU368023};
KW   DNA repair {ECO:0000256|RuleBase:RU368023};
KW   Nucleus {ECO:0000256|RuleBase:RU368023};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274504}.
FT   DOMAIN          78..588
FT                   /note="Cleavage/polyadenylation specificity factor A
FT                   subunit N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10433"
SQ   SEQUENCE   688 AA;  76150 MW;  92E089FED6941498 CRC64;
     MFVYTVALFN GISKIVYING CGNGNFTGPN DLNLVFIKNS YIEIYDITSE GLRVVRDIPL
     NGTILTALLF RRRNRKQDSL CIVTLRADLI VLECVRTKDS IDFVTVFRKN IDSRGHHLLH
     HGVTAMVDPT STYIAIRLFH NLMKLVEINH LPERPGVKVE ESKIHAVKLD EGNVIDLTFI
     NGYGYPTFAM ICEDQGAAHL RMYELNTKDH ILVPLPANFS AIETTSRMLV PVAAPYYGFL
     VVGDEMISYH SPNKPHITTC IPQKTVSVIC SCKVALVSSS AHLYLLSKVV AYAQVDNKRY
     LMGNLCGELF MVHLVGPEVD ALAPLSAVLE RLRIERLGIT SVPESIVYLD KGVVFIGSYF
     GDSQLIHLRS DIDPDTKCYF DVYEEYPNLG PIADMIFVEN EGQNQLITCS GYSRDGSLRI
     IRNGIGIQEI ATIGQEHMNG VWCIPCNSEV YDDAMICSMK RRSRIVRVIG DDLAGLKLEG
     FVRDDRTLYC NTVHPQGYKK SPRPLLLQAT NDTLWLIGIQ DLYGKGCLAT WKPPTGMSLS
     SLTARGDLVI VASGNCIFAL RITGTPEKPV FTQVGQNELA CEIACIDITP FNKSKSADSS
     TAAAGDILGD MEPEYAAVGL WLGHGICLLK LPSLEQVFND PLPKEIRSTG AVILPRSIAI
     AQFDELLYVF CVSGDGTLFY YNVDYSNG
//