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Database: UniProt
Entry: A0A0R3UJQ6_9CEST
LinkDB: A0A0R3UJQ6_9CEST
Original site: A0A0R3UJQ6_9CEST 
ID   A0A0R3UJQ6_9CEST        Unreviewed;      5743 AA.
AC   A0A0R3UJQ6;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   13-FEB-2019, entry version 18.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:VDD81758.1, ECO:0000313|WBParaSite:MCOS_0000776001-mRNA-1};
GN   ORFNames=MCOS_LOCUS7761 {ECO:0000313|EMBL:VDD81758.1};
OS   Mesocestoides corti.
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Mesocestoididae; Mesocestoides.
OX   NCBI_TaxID=53468 {ECO:0000313|Proteomes:UP000046399, ECO:0000313|WBParaSite:MCOS_0000776001-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000046399, ECO:0000313|WBParaSite:MCOS_0000776001-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:MCOS_0000776001-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:VDD81758.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Pathogen Informatics;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UXSR01005405; VDD81758.1; -; Genomic_DNA.
DR   WBParaSite; MCOS_0000776001-mRNA-1; MCOS_0000776001-mRNA-1; MCOS_0000776001.
DR   Proteomes; UP000046399; Genome Assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 9.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 3.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000046399};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000046399};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5061   5080       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5262   5280       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5343   5365       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5541   5564       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5624   5645       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       55    109       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      116    162       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      171    238       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      244    303       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      378    436       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN     1113   1311       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4820   4854       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4855   4890       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4833   4844       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4868   4879       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED     5641   5661       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5743 AA;  634877 MW;  28BC2D9F84E8C530 CRC64;
     MTSRANEEEI SFLRTVPPAN MSPCIFILEQ ALSARALQEM LSSKNELSDS RTSGHRTLLY
     GHAIRLKHRN SSMYLACLST SSTEDKLAFD VGLEREANTE ACWWTIHPAS KQRSVGEKVR
     IGDDLILVSV SSERYLHVYG DSFSSSGVIA SFQQTLWTVI PVSSGVVRQK SLHMAFGGDV
     IRLFHGDECL TIQAADESEE GQLATSVTAS PPDYHQSVMY QLGSVSGHAS SLWEIEHTKI
     RWCAGFFSWE DAVRLRHVTT GRYLGITPAQ ASGNTTAPGQ IDVVLLSPSE SDDASTVFYI
     KQTKAKDVFV GFPIPGKLFV DEEDLTASPG QPTAVTYDHI TTNCSSRPQH QFGSPESTEA
     EDDKKKVEID REHEGMGDPD VCLGETLIYL QHAALGWWLS YESYETKKRG VGKVEEKKAV
     LLAEGHMDDV FSLVRAQEEE SISASAIRRS TAVFSTFNRG LDDFANANAA NSGPAAAPVT
     ASMTPIEGPT LNLDEVNQCL EDLIEFFAQP EAHEEHETKQ SKLAALANRQ DLFQEEGMIG
     LVLETIDKFT GTFRSRREFA LAVGEERGNK FSDLGNYLYL LLAALIRGNR ENCAQFAAPA
     RLDWLFNRLE LQQSFAEGVL DALHCVLTDS DEALNVITAQ HIHTLIGLLD KQGRDPGVLE
     VLYSICMGRQ GGAVRLNQDL IYESLLPDRD LLLQTKLVAQ SGSMRPNVFV GIKPGGSMYT
     KWYFEVFIDA LETVSHQPPG IRIGWGNTDG FTPHPVGGPG WGGISLGDDF YSFAFDGQNL
     WTGGKAKQAL IPLGSKPTLG HQHRSAAHNG SANLKRGDVI GCLLDLTGPV IQFNLNGTLV
     KGYFQDFNTT GLFFPCVSMT ARASARFVLG GNHGKLKHGP PAGYAPIIDA LQPSQRLRLE
     PVFSFGRLDK SIFSGPLASP LPSQDVFVPV PINTEKVHLP TVVERIRDKL AENMHELWAM
     RKIDQGWVFG ERRDESRRRH PCLCSFDKLQ QQERQYNVTM ALENLKTIFA LRYNIGYESL
     PEGTRMKTVK LNASYTQSNG YKPQPLDLSA IRLSSRLETL VDELAENTHN IWAKDRIHQG
     WTYAFQPPVI LDHSNSQEAD FIQLNNHVDC DNAQKRSPHL VPYSEVNSTI KKMNRESATD
     AVKTLIAYGY VIEPVSGDAE QNRENPLDVL EEATMNYRAA SSKAVTRGKW YYEVELLTYG
     MVRVGWATKN APAATTIGMS GSSYSFAPEQ ARKYHRDGRP YGKRCEPGDV IGCMLNLNEK
     SIMFSLNGEI MMDPLGQEIA FKDIKVNDGF VPAFTLGSGQ QVRINFGNVV QTLKYFTICG
     LQEGYSPFAV NMSNAVPMRY SKVDASLFKD LKPNHSRLET KVSGAYPPVI NILAKSPSPT
     GLHQMEYLRL GLGIRCKAQF TTRSLADRRA HLDQLRKQLE PEDYRHHPMG IGGPSSLDLM
     SSEIGASGLE VRDRRGKRAR LANVFRKTRQ RDVSPDVAGG YSGAGGVSLV SGSGSGTGIG
     KKGDPGTSSQ TSGGAHEGSP GPSGEDFELI LPEQSGLDNA IADFMDEFAY TVLIPPGQNP
     CLVNVGWVGS YFKISKPASI SGGNPFPVDP DFNVTQLAQL SSQSTRTTTD GDAVSRSEST
     DSDATGSVVS PEKLINFAES AVAERSSFLV NVGDLIQKTS TPDDIGKRVS QGLAVTCWVD
     TASGTLGFRL NDRDTLCRFQ VEPCTHLFAA VFVRPTARDC VQFELGRRSR YHLPITAGML
     RPPRRANMPI PHRLNVQAIE RVHWAPVPDE QAKIQSMKMS DQRGWSMLLE NSAPRLVIQL
     PEADRCFSIL ELEDMPDLLR FHASTLALYR ALCCHGNHNV AQKLTKHVDQ NQLLYVIQSK
     YIHGSLRSEF VQLLLAMHLE SHMKLKQVTG REFIVPLEKD DLDVQKTPEH VLKIVHDWDP
     DHIPAVTEHR SIRPKLITDP HLLIPGADGT GAGNFVVPAG GAEIQPEAAM TAAIAAAGPG
     GLLKLADCPP FPLDQLKRQT LDALIDMANT GGHVRDPFGG NFEHALLPLL QILNHLLVMG
     SLDASDLATV LGLLSPKLFP NTPVWRVTRI AGSLLELPLP ESVKMEVCRL FHNLCDLQLR
     HRIECIVTFS NTAVSEIQND QMQRYLAIKV ANLPSSVAAP RTREFRCPPN VQIRNLLYMP
     GPGGPSGLLN EPALNASEAA DGENDAATAV LDLGDGGEDG SSDGCSGNPC AEEIKDLMRM
     FHRRLMDHLG VGTPEAEDTW DYKGAIATLH DAIANVSAEH LVSNAVPHLR QSPQPPTASS
     PVEEVVDQPQ SELTELLSTP TLLLPEGVGD PESGAAGPPM AIKAIWDLVS GAANRGGGGT
     TGKGADGGSR QLALGPPEDT KPQGRKLHQL ILETVSHWAK SSIIENVELI RQMFYLLYRQ
     YGALDELRQG LTRTYTIGHR SKEDVSRLLR SLGRIRCLLG VQVGANEEIL LKNCLWDIMN
     NNVFFQHPDL IRVLAVHETV MQLMVHTLSK ASLDSPTASS VAAAQMSTMT ATSEVQLQQI
     EDARPSRHRH GSSGAGSLPV VVEEGEDTTL NGSNTGHRNV SVGPTEMVVQ CCRFLCYFCR
     TSWQNQKAMF DHLSYMLENS SMLLARPSLR GICPLDVAYS SLMDNNELAL ALREKQLEKV
     AVYLSRCGVQ SNAELLAKGY PDIGWDPVEG ERFLDFFRFT VWVNGESVEE NANLVVRLLI
     RRPECLGPAL RGGTKTASSR RQRLNSQQGP NGGDVGDQLA PPGSPEGPVG GGGAGVTSGG
     STTGPADDAH STTASNANSP SSSTVLIHFR QGIKEGIVMS ALIKLVKMAM EAEAQGLNPE
     DEDMGWRTVL MDYEDCNLFA PLPYNFSNLP VRKKSSYSPE DDEDYVDLGA AILTFYSVLV
     DLLGRCAPEL DASKSESVRG RAILQSLVSM QDLEGVLSLR FILPPPKLEM QLNAEGLEQW
     MDRSPMPPGL LPEHKAAVVL FMERVYGLSD ADTFVRLLEN AFLPDMRAVT LLDSAQRGVT
     ASDMTLALNR YICGSVLPLL TRYAHFLAVN EVTAGLLEST LHTAYRLATC WSITNNQRDV
     VSDFLVALVE HIQPFSMTSL IRKIAKNMRT VGRECAVSLR VLTTFYQRFG AYYSSEGWTA
     EYAGAGESGG GGSKAPNQGG ASAGSGGSRD TSKTGDHTFV RPTTTGTTAT ATEEERNLTA
     ELFSLIFNNL SCRRYDAELY VYALPCLTAI GCALPPDYCS SHWDAQSKFG EDDTVGPDVA
     VHPGGPDSTS DHPGCAQQHE SFRPAPLATA SIKLPGALSI LVDQFAKHCH DSWAHELIEQ
     GYVYGPTLDE ARRTHPNIRP YHSLTQRDLI RYIQPVTETL RAMLALGWTI DPSGVCHEDD
     GTGLGLRRRQ FIQNHNETPQ GYNPTPKDLH GVNVTRELID LAERLADNAH QIWAKQKMEE
     LEEIGGGVHQ LLVPYDILTD RERKRYRRLT HELIRYLQYW GYRLSYKPPN QHADTAKPGT
     TPATTAASAT VKQFAGERGE GHPSSRFAYG LLSKLLDYVE GAMSTVREDK PSRMFSRHQS
     LTQTSEDMKL LVKVVLPLLE RYFYTRKSYF IDPYCGASIE EKKMATMLFT KLFTLLRLKT
     RCFGADVNVT VSCLKCLIEC LDIKAIVKIS YAEDFVRVRL MPFFAYCADD LNLLIRNLNS
     GRYSHIKGTI RRGACSIHYV HMILLPTLKT MFEHISKTGV GEDLLLGHLQ VTCYRILNAL
     YVLGTTSRKH ANRPELMEEL NRHRPMLGEC LAALTSCFPV AFLEPELSAH NPRSIAYSVE
     EADYSFEARE SDDKIPEEEL DPFGARDLLQ KIGKTLPSLH DIIDDIVRLA EAGSNCAGEP
     HLIEVTLPML CSYLPVWWRK NIAQRRHATR KGVNLAFFPD NDQVLSQVEL DGDLDGDQSN
     ESDDDDEKGW GAATGPITTV TADLMNRVLG SVLQLIQNNI DSINAPWMTR IATRTQPIVG
     NATVDMLGKY FLPVSERLLE QAFAVQSLER RLSNETDKEG ELTAACELLV RNMFALYPLL
     ITFVDRYRTE WLKQPTVETD RLFNAVANLF LIWNGSPNFK REEETFVGMH ELDTLALIMP
     SSERGQISTD VGPRSLTQQP SKSGKALKKG FTSLMVASVK RLLPIGLCVL GGKQQELVQR
     AKRMLLKHEV EADIVDYLRF ALDRDDDSEM KGYRWQKLLY QKIDRTIAQT GCHEALGVST
     KDEIINRIMT LAKVMHALYL VSHVVPTTLN RGAWKKLVST QRKRAVMACF RMQPFYALPR
     HRAINHFLMA YHDGWLRYEQ SLGVQLIEEI TCASGEENPL SITTGALPIA AAPIAGMAPS
     AGGGGGEGGV PGGAGASDDM DVVAAISKAI IEASAYSDSS DEDNISLSGS GESAGGGGGG
     GVGVANVGPA DQSGGGGDTD NTQSSGSPHS IFATDFCATP DPLRQLITAL CRTAMEQASD
     DRLYLAFARI MAKACHTFSQ SSTNTSKVHA CLSLHYHLDI RCVLQSCSGK DDDEDSGGGG
     DEDEDEEGPT SQEQEEQKQR LLFEQNRLSN RGAAEMVLLQ LAASKGEATP VAMASVELGI
     AILLEGNVSV QNRMLAYLVE KRLTGFFTSV AGLMQNCSVL DLDTFERCRK AEGLAVGLSD
     MEGITNLYDA DFTCKIFRLL QLMCEGHNSA FQDYLRTQSS NTTSVNLIIS TVDYLLRLQE
     SIMDFYWHFS NKPVIDDSGR TNFIKAIKIG KQLFRTLTEY IQGPCQGNQH ALANSRLWDA
     ISGFFYLFAH MQDKLSKDPE QLDLLHEFLN LQTEMMIMLL SMLEGNVVNG SIGRQMVDTL
     AESSANVELT LTFFDIFLRM KEITNSDAFL AFDINKDGWI SHREFRTALE QQKSLTEEEI
     NYIMGCVDAN SDGKIDFQEF TERFYNPARH IGFNVALLLT NLSEHIPGDV RLERLLQKAK
     GMLEMFDPLL GRIEITNKEG RIERVYFEVR QENIDQWEKP QIKDSKRTFL HSVVGESGDK
     EKLECFVNFA EDTIFEMQHA QGISGDDENL QISRVVAVRN LLEATRLTSF FAFLGTVLSF
     LSPHHLWKCW ISLQQMSLVD LIADILGLII GLMIGAVRVV KGILSISARF VVAMASDPNA
     PPPPPPPPPF VAVRPPASTM SAGPRFATLK PEPPADTELK PPDPVTANGN AHKHTDLASI
     LQEKECWLLS EEEQLLLERV DPSKVEMIVG EPAKPSSPGT SRTAAACKPS ASTRGKPPQG
     GSHTQPASRE SSEESVVVEQ KPIPTSTFLI SIFARNFYRF KLFALILAFI INCLLLFYKI
     ERIDTNGDEG ADEAVSSSIV SSITNTVSNI AESLRDPGPS GEADRPDEEF ITLAESASYL
     GPLLKVLAIA HSILSLSMLV AYYFLKVPLV IFKREKEISR MLEFEGVWIA EQPSDEGLRA
     QWDKLVLSTP SFPHMYWDKF VKKKVLKKYR EQYDQRQIMR LLGMKAGCSG AGGGGGGVRT
     DECSNSWWYP TWLQELDLQY LLWKWGVIFT DNSFLYLVVY FIVSLLGNMN YFFFSCHLLD
     VAISFKTLAT IVQSVTHNGK QLVLTVMLTS IVIYLYTVIA FNFFRKFYAK EEDGEKEYKC
     NDMLTCFVFH LHTGLRAGGG IGDEIEPPDG DANEALRIIF DMSFFFIVII ILLAIIQGLI
     IDAFGDLRDQ LEQVREDLES KCFICGIGKE YFDSTPHGFD RHVEREHNFA NYMYFLMHII
     NKPDTEFTGQ ETYVWELYQQ RCLDFFPIGN CFRKQYEEEL QAK
//
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