ID   A0A0R3VU85_TAEAS        Unreviewed;       859 AA.
AC   A0A0R3VU85;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   22-FEB-2023, entry version 21.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Taenia asiatica (Asian tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX   NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000085901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TASK_0000085901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; A0A0R3VU85; -.
DR   STRING; 60517.A0A0R3VU85; -.
DR   WBParaSite; TASK_0000085901-mRNA-1; TASK_0000085901-mRNA-1; TASK_0000085901.
DR   Proteomes; UP000046400; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        414..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        552..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        585..605
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        648..667
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        789..814
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   REGION          684..709
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   859 AA;  98195 MW;  5098081D6CA562F0 CRC64;
     LCELRKREMG AMFRSERMQL SQLFLHIDSA YMCIVELGEL GVVQFRDTNA ERNAFQRKFV
     NEVRRCDEME RKLRFMLNEI QVNKLKLYDS PEIPEAPAPR EMIDMETTFE KLENETKEVN
     ASIGNLRQTY FELQEMKHLL RKTQIFFDEA HQTPSFTTDE NLGLLGEEGS QTTYSGAEMH
     LGFVAGVVLR EKLSAFERML WRACSGNVFL KQAEIELPLE DLLTGEKVYK TVFIVFFQGD
     QLKTRVTKIC EGFHATVYPC PESAADRRTM LIDVVQKIDD LETVLTQTQQ HRQRILEAAA
     KNLNNWFIRV RKMKAIYHTL NLFDLDVTTK CMIGECWCAV SDLDQINLAL CRGMQKSGST
     IQPILNVMPT KDSPPTFHRT DKFTEAFQGI VDAYGVATYR EVNPALFTLI TFPFLFAVMF
     GDAGHGLVMF LFGLFMALWE RRLISMKIKD EVFDIFFGGR YVILLMGAFS IYTGVIYNDI
     FSKSVNLFGS SWYPGYDKHV ISSKSLLQLE PRTSENITDQ MFAGQPYPFG IDPIWQISNN
     KIPFMNSLKM KISIILAVLH MIFGVILSFF NHKFFNNTLS IWCEALPQLL FLTSIFGYLV
     IIIFYKWGAY TADEASTAPS LLLVLINMFR FNYEVKGGAG DPFYGGQAVI QSILMLIALA
     CIPWMLLSKP FILRWRFKRS AILDHGSQPK PTPPPRPPKP DLNSGQRSKE PDANYAAQVV
     VADDHDGDLE HFDFGECMVY SAIHTIEYCL GCISNTASYL RLWALSLAHA QLSEVLWSMV
     MQNGLKIDAY YGSVFLFLIF SAWAGLTVGV LVLMEGLSAF LHAIRLHWVE FQNKFYSGTG
     HLFEPFSFRA YINQPLNEP
//