ID A0A0R3VVN8_TAEAS Unreviewed; 1003 AA.
AC A0A0R3VVN8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=[heparan sulfate]-glucosamine N-sulfotransferase {ECO:0000256|ARBA:ARBA00012979};
DE EC=2.8.2.8 {ECO:0000256|ARBA:ARBA00012979};
GN ORFNames=TASK_LOCUS1462 {ECO:0000313|EMBL:VDK23088.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000146101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000146101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK23088.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. NDST subfamily.
CC {ECO:0000256|ARBA:ARBA00010420}.
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DR EMBL; UYRS01000386; VDK23088.1; -; Genomic_DNA.
DR STRING; 60517.A0A0R3VVN8; -.
DR WBParaSite; TASK_0000146101-mRNA-1; TASK_0000146101-mRNA-1; TASK_0000146101.
DR UniPathway; UPA00756; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0015016; F:[heparan sulfate]-glucosamine N-sulfotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR021930; Heparan_SO4_deacetylase.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF56; BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF12062; HSNSD; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000282613}.
FT DOMAIN 325..592
FT /note="Heparan sulphate-N-deacetylase"
FT /evidence="ECO:0000259|Pfam:PF12062"
FT DOMAIN 693..922
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 700
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 789
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 797
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 920
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 950..954
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 921..945
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 1003 AA; 115229 MW; CB8B7054C1C8D734 CRC64;
MTWKRYFLFF VCVGIIYLVA HRFDNVNIGS QSFVLNVRSH NLQTSVPPRL PNDIYRPKHP
HPLILLITVS DRAISEDARL VISVVQSLRL AIHPLNPMSF SSQIHQLISA KYFQMVIFED
FLIYFSLPAV AKSALDDYCK TNRVAVIAFF QNAHTLRGIP GNEDFAEIDP SYPLLFRSFA
TSSSPKGFFL SRESDVLHIA RGGQVDERDL TDQLPPCRDW QRRSPMCFPL RRDGYPQLLS
DVTAFVRHFV YLLPDFVSVL GRSCVTKASV WREYQKWRRS WAALVPRNSS DTDAFQTVAF
TQVPLGRGTE LERRSCAFRD NNVKKTVECD DAAVYQSLVL KDVGKIDGIE RLLFAFGPLQ
HWSTSLLLND AIHHFLKDSA VLEYDLGLQR YIHIDIDDVF VASRGTRMTV ADVENLIETQ
NRWRRFMPGF TFHMGFSGMF FLHGNAKEQL GDETLIRHRH HFKWFCHTYS HLQAHLLSES
ELLDQLKLNK QFAEEKDLPI ADGYAVAPHH SGVYPIIPHL YTAWKEVWNI NVTTTEGYPR
LFPSRFRRGF HYQGVQVLPR EVCGVYTSTM RLSDYPGGIE KLEGMAFGGD LFDTLLFRPV
NLYMTHFGNY AQDRLALYVF ERVFAFLHKW TRLKVQWAPI WRLMEYHLSF NPSERASAPT
SLPLYSDPCA DPRHEAIWFP SACTPNARRL PAAVIVGPQK TGTTALLAFM AMHPNLQPNR
FLPHPPYEEV QFFSNSTIYS KGVSFYNDQF LSSSTGINFE KSATYFDSPL AVMRMAALLP
TAKIIVLLRD PMLRAHSWYQ HQRAHQVPAA LHFTFTEVLK ASSLGEATAV ATAASSSFNV
THLAPQLYQL HLKCVEPSTY ATHFRHWFHH YRASRMLLVD VERLESNPAE VLRDVQEFLN
VSTFIDYSTL LVRNERKGYY CARGGPYPKA GQLLKPDGLL EDVWCLSESK GRNYDHSLDG
TNHSAFFAES NRELASLILR YPFWRPMRSR SASDLLPQWL RNF
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