ID A0A0R3VW99_TAEAS Unreviewed; 669 AA.
AC A0A0R3VW99;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 22-FEB-2023, entry version 33.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
GN ORFNames=TASK_LOCUS1694 {ECO:0000313|EMBL:VDK23504.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000169301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000169301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK23504.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR EMBL; UYRS01000522; VDK23504.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R3VW99; -.
DR STRING; 60517.A0A0R3VW99; -.
DR WBParaSite; TASK_0000169301-mRNA-1; TASK_0000169301-mRNA-1; TASK_0000169301.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd10491; MH1_SMAD_2_3; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR PANTHER; PTHR13703:SF25; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Reference proteome {ECO:0000313|Proteomes:UP000282613};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 9..134
FT /note="MH1"
FT /evidence="ECO:0000259|PROSITE:PS51075"
FT DOMAIN 476..669
FT /note="MH2"
FT /evidence="ECO:0000259|PROSITE:PS51076"
FT REGION 143..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 71744 MW; ECF44E62C8358D5A CRC64;
MSLFVTPLPV VKRLISYIKE GSDKEEKWKE KAVKSLVKRL KKGNQLDELE RAIVNQDSST
RCVTIPRSLD GRLQVAQKKG LPHVFYCQLW RWPDLHTQHE LRPVENCQYS FQAKRDEVCI
NPYHYRRIEN PIIPPIMVPR APHPPSQASM NGADGMSSYG HHHHHHHAAY RAGMSQRLGG
ATTSNASRHT MMDYTSGGAG GGSAAAAAAA AAAAYRTGAP TQAGLMAPPP PSTGLPQTPY
GDTPSSSHHL TSLTALLNSS TAAGCCKFEE EMDTSGSLLG TSMAPPCVTL DENADHEVLG
GTPHVVFSTP LVSSGMGAGM GSSYRSSGDD STTRSSSPHT GSMLSYLSHG LKNSMAMKSS
PPTTSSPPQM SPTNCSKTTG AGTGKSEEGG ESSAGLAGTT DALSCTAPGS SSSGGGSGDA
TSTGGLDSRS PGALSRDENC LSEDNDTMDT GLDTLNDITI DDSAHTSVAY QEPDYWCSVY
YYETNTRVGD TFYCASPCLT VDGFTDPSRE NRFCLGLLSN VNRGHQIELT RRHIGHGVAL
YYIGGEVFAE CLSDSAIFVQ SPNCNHMYNW HPATVCKIPP GCNLKIFNNQ HFAALLKESV
NNGFEAVYAL TNMCTIRISF VKGWGAEYRR QTVTSTPCWI ELHLNGPLQW LDRVLSQMGS
PNHPCTSVS
//
