ID A0A0R3W9N7_TAEAS Unreviewed; 1282 AA.
AC A0A0R3W9N7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN ORFNames=TASK_LOCUS7185 {ECO:0000313|EMBL:VDK37996.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000718401-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000718401-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK37996.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-
CC isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666,
CC Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528,
CC ChEBI:CHEBI:456215; EC=6.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000114};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR EMBL; UYRS01018585; VDK37996.1; -; Genomic_DNA.
DR STRING; 60517.A0A0R3W9N7; -.
DR WBParaSite; TASK_0000718401-mRNA-1; TASK_0000718401-mRNA-1; TASK_0000718401.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07961; Anticodon_Ia_Ile_ABEc; 1.
DR CDD; cd00818; IleRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033709; Anticodon_Ile_ABEc.
DR InterPro; IPR002301; Ile-tRNA-ligase.
DR InterPro; IPR023586; Ile-tRNA-ligase_type2.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR PANTHER; PTHR42780:SF1; ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR42780; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF19302; DUF5915; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00984; TRNASYNTHILE.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000282613}.
FT DOMAIN 19..676
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 732..911
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT REGION 1019..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1282 AA; 144237 MW; E2208639BA09EF07 CRC64;
MSRDDLPPSL NFSEEEEKIL QFHNEIEAFK TSCKLSAKRP PFTFYDGPPF ATGLPHYGHI
LAGTIKDVVT RFAYSEGYHV ERHFGWDCHG LPVEYEVDKL NNINGPQDVE AMGVAAYNAK
CREIVMRYSL QWRSVVQRIG RWIDFDEDYR TMYPTFMESV WWIFKQLYEK GLVYRGVKVM
PFSTACSTPL SNFEAGLNYK DVQDPAIVVS FPVEGLDDNI SVELLAWTTT PWTLPSNLAL
CVNPEKDYVK IKDKSRGRVF IIMECRLEWF YKKAEDYEIL EKMKGEKLVG LKYKPLFDYF
IKLKESRGAF RVVGDAYVTE ETGTGVVHQA PYFGEDDFRV CLREGIVTKE MAPVCPVDAS
GRFTAEVVDF AGQYVKDADR LICQHLKHAG RLVHQSTLQH SYPFCWRCVY VFFTFIRSHP
ASFKSQIQHC DWVTGGLGYR SDTPLLYKAV PTWFVRVECL VERLLVNSAA TYWVPEFIKE
KRFANWLRDA RDWAISRNRY WGTPIPLWVS EDFEEVVCIG SLDELERLSG HRVTDLHKEF
VDPITIPSRM GKGELHRISE VFDCWFESGS MPYAQMHYPF ENAERFNSGF PADFVAEGVD
QTRGWFYTLF VLSTALFDQP PFKNLIVNGI VLASDGQKMS KRQKNYPDPC KIVEQYGADA
LRLYLVNSPV VRAQSLRFSE SGVRDVLKDV FIPWYNAFRF LMKSGIEPWE RAHGTTFRVR
PEAWPKSRNL MDRWVLSFTQ SLLSFVRTEL RAYRLYTVVP RLVCFIEQLV NWYIRMNRRR
LKGEAPTETG VATDAEEDWY GALHTLVKVF FQLIFVMAPF APFFTEFIYQ RLKAKLDFSK
FPLEGLSDGE SGAVGADLAP ASVHYLVGVS AESRGIDEAL EARVAWMQAA VELGRSIRTR
HDLPLKAPLR ASVVIHPLAE AREAVTALAS YVTEELNVRN LTVTHDKATY QVRLRARLNP
VLGARLRARL RPLAAAVAAL PQSSLEAYLT TGEMTVEGEL LSGDDVTVDY VVGDEANTEN
NNVKAKGSKG KSKENGGAPP PEVADGPKYK AHADGKGMLV LLDVRADTEL EEERVAREII
NRIQRARKKG NLVPEDAIQV VISTISEVLP RVLASHAALI DATVKQPIVC CTTEDAASTT
ATAAVQARGE QLGGIVVSDS TTIPPDDLVV TIFHRIAATK DAVGCSTTTA TATSKPQVPG
VCSSAKSLKV VCPVVKKSID VCLVDAAGKQ LITGVLELLD VVRGAFDWRL AANLRLMHSG
TELTCDSTVN VLNLAGQELC LV
//
