ID   A0A0R3W9U9_TAEAS        Unreviewed;       975 AA.
AC   A0A0R3W9U9;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=[histone H3]-lysine(27) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012186};
DE            EC=2.1.1.356 {ECO:0000256|ARBA:ARBA00012186};
GN   ORFNames=TASK_LOCUS7260 {ECO:0000313|EMBL:VDK38099.1};
OS   Taenia asiatica (Asian tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX   NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000725901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TASK_0000725901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDK38099.1, ECO:0000313|Proteomes:UP000282613}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC         + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC         COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC         Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR   EMBL; UYRS01018595; VDK38099.1; -; Genomic_DNA.
DR   STRING; 60517.A0A0R3W9U9; -.
DR   WBParaSite; TASK_0000725901-mRNA-1; TASK_0000725901-mRNA-1; TASK_0000725901.
DR   Proteomes; UP000046400; Unplaced.
DR   Proteomes; UP000282613; Unassembled WGS sequence.
DR   GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd10519; SET_EZH; 1.
DR   Gene3D; 2.170.270.10; SET domain; 2.
DR   InterPro; IPR026489; CXC_dom.
DR   InterPro; IPR045318; EZH1/2-like.
DR   InterPro; IPR048358; EZH1/2_MCSS.
DR   InterPro; IPR041355; Pre-SET_CXC.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR   PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR   Pfam; PF21358; Ezh2_MCSS; 1.
DR   Pfam; PF18264; preSET_CXC; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51633; CXC; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000282613};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          643..741
FT                   /note="CXC"
FT                   /evidence="ECO:0000259|PROSITE:PS51633"
FT   DOMAIN          802..930
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          304..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   975 AA;  108907 MW;  B686175A90953CF6 CRC64;
     MFDRAFFTKA SRNPGRRSQR NTTYTDDRSS IVGCVNSNTR RRRSNRRYPA GSTRQRSDSR
     KRILQNAIRD IYQFIRKRHL LAKWNRVGVL YRRNDALIDK QLKEAANRNW KNLSVSGGGV
     SSNAPLLAAP VEIPQLYSQL GRFEAKINGY VARVGVSIIP PVDPVPAMSS WAPVQLNYSV
     EDEPVLNHLP YMGEEQAQDD VFLEELLNNY DGRLHGNFPF DFESHLTVEL VDTVHSKWET
     LPNTEVVESP RSFHFDCEGH HREKVENGPC GQVAVENHNK FEQENRANED GAISYKSKLS
     TLASNSSKCP SSSPKNSAAA PDASAEANVS RVSSDSGISE PVFKAIALTF GSVEDSNKLQ
     VHYCEMKNAG NNSVTPETGT PSCPNLDDPV EVKEVCDREQ KRPSRHDALH TFRALFCRRC
     FKYDCALHPY KSTQTMWSHR WPVKSWACSN LPLCGPDCIR ALRGASAENA GKEYKAKEGE
     KEPEWEITEQ TLFEVLAPIY VPFGQPSFQN HNWCCVISGF IKTRTCKEIL RYCESKIAKD
     PFVLFGHDAG QSRLVNQYND EVSIPNIRNG KRFFGDANSD FDDLISDDED GVGANGDLIG
     FLVGGKKRRR KAKRSRISLV KHPFASRRPG SVNEASDPPP GHVGKAELTT GCLSNYFQPC
     DHPGSRCNES CSCRKAGNFC EKFCQCSVGC SNRFTGCRCR GQCNSRVCPC VLAIRECDPD
     LCHSCGAGTS RQPLVGTQEA GLNVDDNGNS NSSLTHATTC RNVAIQRGLR KHLLMASSDV
     AGCTVLLPHF SLPIFFFLFI TTSVHRLSAI LDTCKGLFHS KLVSYRWGIF MKDGAEKNEF
     IYEYCGEIIS QDEAERRGKI YDRTMCSFLF NLNRQFAVDA MRKGNKIRFA NHSINPNCYA
     KVLMVNGDHR IGIFAKRAVQ PGEELFFDYR YGPTHQLKYV GIERDDEMAV ATQAAAVALI
     DGGISSGFAP YATNN
//