ID   A0A0R3WB96_TAEAS        Unreviewed;       619 AA.
AC   A0A0R3WB96;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=asparaginase {ECO:0000256|ARBA:ARBA00012920};
DE            EC=3.5.1.1 {ECO:0000256|ARBA:ARBA00012920};
GN   ORFNames=TASK_LOCUS7898 {ECO:0000313|EMBL:VDK39206.1};
OS   Taenia asiatica (Asian tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX   NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000789701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TASK_0000789701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDK39206.1, ECO:0000313|Proteomes:UP000282613}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYRS01018692; VDK39206.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R3WB96; -.
DR   STRING; 60517.A0A0R3WB96; -.
DR   WBParaSite; TASK_0000789701-mRNA-1; TASK_0000789701-mRNA-1; TASK_0000789701.
DR   Proteomes; UP000046400; Unplaced.
DR   Proteomes; UP000282613; Unassembled WGS sequence.
DR   GO; GO:0004067; F:asparaginase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009066; P:aspartate family amino acid metabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.40; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR   Gene3D; 3.40.50.1170; L-asparaginase, N-terminal domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036152; Asp/glu_Ase-like_sf.
DR   InterPro; IPR006034; Asparaginase/glutaminase-like.
DR   InterPro; IPR027475; Asparaginase/glutaminase_AS2.
DR   InterPro; IPR040919; Asparaginase_C.
DR   InterPro; IPR027473; L-asparaginase_C.
DR   InterPro; IPR027474; L-asparaginase_N.
DR   InterPro; IPR037152; L-asparaginase_N_sf.
DR   PANTHER; PTHR11707:SF28; 60 KDA LYSOPHOSPHOLIPASE; 1.
DR   PANTHER; PTHR11707; L-ASPARAGINASE; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00710; Asparaginase; 1.
DR   Pfam; PF17763; Asparaginase_C; 1.
DR   PIRSF; PIRSF001220; L-ASNase_gatD; 1.
DR   PIRSF; PIRSF500176; L_ASNase; 1.
DR   SMART; SM00248; ANK; 4.
DR   SMART; SM00870; Asparaginase; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF53774; Glutaminase/Asparaginase; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS00917; ASN_GLN_ASE_2; 1.
DR   PROSITE; PS51732; ASN_GLN_ASE_3; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Reference proteome {ECO:0000313|Proteomes:UP000282613}.
FT   DOMAIN          63..204
FT                   /note="L-asparaginase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00710"
FT   DOMAIN          225..340
FT                   /note="Asparaginase/glutaminase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17763"
FT   REPEAT          438..466
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          535..556
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   ACT_SITE        101
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10100"
SQ   SEQUENCE   619 AA;  67990 MW;  E15F8BC51F8559BA CRC64;
     MPIFNDPQKI AFYFRFWEHA PPLDNSTSTS STSIKTSTPS TVSMPLAMPL DEDGRRILYR
     LLEYDTLLDS SDCQLEVWIN LAKDLERFYD HFNGFVILHG TDTLPYAASA LSFILENLTK
     PVVMTGSELP IDRLRNDGRT NLLGSLLFAG GGYNIPEVTV FIQNELYRGN RIVKAATTDL
     EAFLAPNSEP LAVMEEHVKV FKERIWPAPK QASAQLRVQS NLCPNVAILR LFPSIPIDAV
     RSFFQPPMKG VILETYGTGN VPSNNTELIE VLKEAHDVHN IVLLNVTQCW KGTVADVYAT
     GAILSSVGAV SGCDITTEAA LMKMAYVLGK WDDPATQRRM LSHSLRGEMT EPFVETRCHR
     HQSVGTSQAS EGWAPKEMTT ALGEALVNAE AAGLSRQWSE NLFHSLICAA ADHDDVEMLE
     QILRISGHFE ARNGHVHPLH VAAGAGAYAA CRLMLENGAS ANVADARGFT PLSYAVRGRK
     CTPELIKLLR NFGCCLPPIA SARAREANIA ASGGKLRQLR FYRLAGLTLQ ELDAEGRSTL
     HTAVAYHQTE VVRYLIAPVE AAIATLDFED NKENDLFELG GAGVDPNHLT GYGTTALEEA
     RKRNFLDIVQ ILESASATH
//