ID A0A0R3WDT9_TAEAS Unreviewed; 657 AA.
AC A0A0R3WDT9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Protein arginine N-methyltransferase {ECO:0000256|PIRNR:PIRNR015894};
GN ORFNames=TASK_LOCUS8945 {ECO:0000313|EMBL:VDK41349.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000894401-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000894401-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK41349.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. {ECO:0000256|PIRNR:PIRNR015894}.
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DR EMBL; UYRS01018936; VDK41349.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R3WDT9; -.
DR STRING; 60517.A0A0R3WDT9; -.
DR WBParaSite; TASK_0000894401-mRNA-1; TASK_0000894401-mRNA-1; TASK_0000894401.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR007857; Arg_MeTrfase_PRMT5.
DR InterPro; IPR035075; PRMT5.
DR InterPro; IPR035248; PRMT5_C.
DR InterPro; IPR035247; PRMT5_TIM.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10738; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR PANTHER; PTHR10738:SF0; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR Pfam; PF05185; PRMT5; 1.
DR Pfam; PF17286; PRMT5_C; 1.
DR Pfam; PF17285; PRMT5_TIM; 1.
DR PIRSF; PIRSF015894; Skb1_MeTrfase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR015894};
KW Reference proteome {ECO:0000313|Proteomes:UP000282613};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PIRNR:PIRNR015894};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR015894}.
FT DOMAIN 67..249
FT /note="PRMT5 TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF17285"
FT DOMAIN 261..461
FT /note="PRMT5 arginine-N-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF05185"
FT DOMAIN 473..655
FT /note="PRMT5 oligomerisation"
FT /evidence="ECO:0000259|Pfam:PF17286"
FT ACT_SITE 436
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-1"
FT ACT_SITE 445
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-1"
FT BINDING 287
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT BINDING 296..297
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT BINDING 390
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT BINDING 418..419
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT SITE 290
FT /note="Critical for specifying symmetric addition of methyl
FT groups"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-3"
SQ SEQUENCE 657 AA; 74015 MW; 6157D452FFCD2379 CRC64;
MMNSNLVGLR IETFDDVRKH FQIARNEGFA FIGIDLFPVL HLCPQSPHDV DEMLPLVRSG
DVYPKKDCDS KDIRVSCISE HCLRKELSWA VHLALPAIEV PLRHDNNVKL AQLLTAFIKS
EVASIKIWIS VPMYTEGDVG QDASSPWHWW SQLVGLAGPA ACESLGLLLE VPTDLPEEDV
VSRWLSEPVS CLALSTHLFI TNSKGFPILS RAHQHVLRQF LKINSQVLIM GPSHHERGPS
IYRQYISWIW KCTVEAKSLY EKHSMGFEDQ LQEPLQPLQD NLSSATYGVF EMDPYKYKAY
EEAICLALVH RCTSRKVVES YQSPLPEVDS KGDSSVKQAM LYPVYSKVVS LDISTNIVIY
ILGAGQGPFV DASLQASRRS GCPVRVYVIE KNSNALLTLK HRMQTDWSGE DVHLVPGDMR
CLSIPPPEKA DIFVSELLGS FGDNELSPEC LDGAQYLLKG ESLRYDGISI PASYTSYVAP
LQSLRIYIDT SRCMENLKFQ ERIQRHSETP YVIRLSNCQI LAAPEEAFTF KHPRKGGPLS
PVGYQDIDTT PNARYCRLTF VPRGDGVVHG FAGYFEAVLY DKITLSTHPQ RHSPNMFSWF
PMVFPLVSAM PVKAGQRITF HLWRCISPRH VWYEWATTEP TVSKIHNSAG SAYKIGL
//