GenomeNet

Database: UniProt
Entry: A0A0R3WFD4_TAEAS
LinkDB: A0A0R3WFD4_TAEAS
Original site: A0A0R3WFD4_TAEAS 
ID   A0A0R3WFD4_TAEAS        Unreviewed;      1130 AA.
AC   A0A0R3WFD4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   08-MAY-2019, entry version 16.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=TASK_LOCUS9578 {ECO:0000313|EMBL:VDK44177.1};
OS   Taenia asiatica (Asian tapeworm).
OC   Eukaryota; Metazoa; Platyhelminthes; Cestoda; Eucestoda;
OC   Cyclophyllidea; Taeniidae; Taenia.
OX   NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000957701-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000957701-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:TASK_0000957701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:VDK44177.1, ECO:0000313|Proteomes:UP000282613}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; UYRS01019260; VDK44177.1; -; Genomic_DNA.
DR   WBParaSite; TASK_0000957701-mRNA-1; TASK_0000957701-mRNA-1; TASK_0000957701.
DR   Proteomes; UP000046400; Genome Assembly.
DR   Proteomes; UP000282613; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000046400,
KW   ECO:0000313|Proteomes:UP000282613};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000046400};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      106    480       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      545    986       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1025   1108       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
SQ   SEQUENCE   1130 AA;  127781 MW;  99F91B15AF82E57C CRC64;
     MKRGRPKNGV GEGLQPSDFE VELMVFDENE VTDEAILVDE SDVVTADISM TLPRTWLRPP
     ILPFDAAKEK LVFQQMDIDF YKGPKLSAMP GPNHSSVPII RVYGVSENGH SVLAHIHGFM
     PYFYVAAPQH FVQEHLLEFR RELNLALHRE LKGNQSEGLK DLVLNVELEE KESIFGFHGN
     VKSKFIRIVL ALPRFIATAR RLLENGFSFG VFSDWSYAPF EANVDFETRF MVDVNMTGCC
     WVELPAGKYF LRQKSQITSP SKVPLKETNL AASTGEFFSS VAGQTRCQLE VDIAWNDVVI
     YPTEGEWSKI APIRILSFDI ECAGRKGVFP VPEHDAVIQI ANMVIRYGDS KPFIRNVFTL
     NTCAPIVGSR VICFATEIEM LSRWAHFVRE VDPDMITGYN IQNFDLPYLV NRCNHLKVSS
     FPFLGRVLGS KSVVRESLIH SKQMGRRENK YVSIDGRIQF DLLQVLLRDY KLRSYTLNAV
     SYHFLKKQKE DVHHSIINDL QNGNDQTRRR LAIYCLKDAY LPLLLLDKLM LVANNVEMAR
     VTGVPIAYLL KRGQQVKVVS QLLRKAREHG LLLPTQRPGQ GDEYVGGTVI EPQRGFYNEP
     IATLDFSSLY PSIMVAHNLC YTTLLKPEDI SASGGISGLL ANYNLGPDDY IRTPGGAYFV
     KKHIRKGLLP CVLEQLLEAR TKAKREMVAE TDHFRRRVLD GRQLALKVSA NSVYGFTGAQ
     VGKLPCLEIS SSTSGFGRDM IEETKRLLEG RFTIENGYKG DAKVIYGDTD SVMCKFGVST
     VEEAMQLGRE GAEYISGKFV NPIKLEFEKV YFPYLLINKK RYAGLYFTKP DKYDKMDCKG
     IETVRRDNSP LVANLVNACL ERILIDRDPS AAISHAQRTI SDLLCNRIDI AQLVISKELT
     RTDEEYTGKQ AHVELANKIR KRDPGSAPQL GDRVPYVITS VGGKNTAAYA KAEDPLYVLQ
     HNIPIDAKYY LENQLANPLM RIFEPILGEA KAKSAILTGE HTLVKSVLHS KVGQLTAFTQ
     KRVSCVGCRS LLPKDHETEA LCTYCQSRAS EIYQKGTERL RALEARYARL WTECQRCQGS
     IHEQIICARK SECLDFNFSR DCPIFYMRTK AQTDLDEQVT IMKRFGEPSW
//
DBGET integrated database retrieval system