ID A0A0R3WLD4_HYDTA Unreviewed; 736 AA.
AC A0A0R3WLD4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=ATP-dependent RNA helicase {ECO:0000256|RuleBase:RU365068};
DE EC=3.6.4.13 {ECO:0000256|RuleBase:RU365068};
GN ORFNames=TTAC_LOCUS1559 {ECO:0000313|EMBL:VDM18210.1};
OS Hydatigena taeniaeformis (Feline tapeworm) (Taenia taeniaeformis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Hydatigera.
OX NCBI_TaxID=6205 {ECO:0000313|Proteomes:UP000046396, ECO:0000313|WBParaSite:TTAC_0000157201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TTAC_0000157201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM18210.1, ECO:0000313|Proteomes:UP000274429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA helicase. {ECO:0000256|RuleBase:RU365068}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|RuleBase:RU365068};
CC -!- DOMAIN: The helicase domain is involved in the stimulation of RELA
CC transcriptional activity. {ECO:0000256|RuleBase:RU365068}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX1 subfamily.
CC {ECO:0000256|ARBA:ARBA00008765}.
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DR EMBL; UYWX01000375; VDM18210.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R3WLD4; -.
DR STRING; 6205.A0A0R3WLD4; -.
DR WBParaSite; TTAC_0000157201-mRNA-1; TTAC_0000157201-mRNA-1; TTAC_0000157201.
DR Proteomes; UP000046396; Unplaced.
DR Proteomes; UP000274429; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR CDD; cd12873; SPRY_DDX1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24031:SF307; ATP-DEPENDENT RNA HELICASE DDX1; 1.
DR PANTHER; PTHR24031; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU365068};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|RuleBase:RU365068};
KW Hydrolase {ECO:0000256|RuleBase:RU365068};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365068};
KW Reference proteome {ECO:0000313|Proteomes:UP000274429};
KW RNA-binding {ECO:0000256|RuleBase:RU365068}.
FT DOMAIN 54..242
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 252..423
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 482..680
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 736 AA; 81129 MW; 32F9ABBC109C4C2A CRC64;
MGVLPELSKA VQEMDWILPT DIQSEAVPLI LGGGDVLMAA ETGSGKTGAF CLPVIQIVYE
TIKDLEGGKS IKKATGGDAV GKKNVCLNVF DRTEAFAIDP NGLLCQSRDQ FAWHGARATK
GVRNHGKYYY EAKVNDDGLC RVGWSTALAC YDIGTDAESF GFGGTGKKSH RRQFDDYGES
FGLNDVLGCY LDLDSRTVSW SKNGNRFPKA FDLPVHHVSS GLFPSVSLKN AELLLNFGEA
RFAFPPSDGF ISINAAEEKN VVLSSYTGGK SQGSFKPSAK SPLALVVEPS RELAEQTYDQ
MKKFKKYLAD PSPRVTLVIG GTSAKELTEE INKGVDIVVA TPGRLEDMVS TGALLLSNCR
FFILDECDGL LSAGYGPMIQ RLHALCPKVT SDGKRLQMVV CSATLHSFDV KKIANQLMHF
PVWIDLKGQD SVPETVHHVV CPVDPYQDTS WRQMMSQSGQ HIQTDGVHMR DQLNPNYETS
ELMSEAVKLL KGQYVVRAIE RQKMDRALIF CRTKLDCDNL EKYFTALGGG PSKFHGQFSC
VCLHSDRNPA ERKTNLQKFK NGDVNFLICT DVAARGIDIT GLPYVINMTL PDEKQNYIHR
IGRVGRAERM GLAISLVATC KEKVWYHANC ASRGRNCFDT RLVSGGGCCI WYNEKQLLGE
IEEHLGITID TISKDLQVPV NEFDGKVIYG QKLKSVAPSY EGHTAVLREA LKELNAMEKK
AQISFLNLRY GSAVKC
//
