ID A0A0R3X0X0_HYDTA Unreviewed; 985 AA.
AC A0A0R3X0X0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Replication factor C subunit 1 {ECO:0000256|ARBA:ARBA00020401, ECO:0000256|PIRNR:PIRNR036578};
GN ORFNames=TTAC_LOCUS6792 {ECO:0000313|EMBL:VDM31061.1};
OS Hydatigena taeniaeformis (Feline tapeworm) (Taenia taeniaeformis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Hydatigera.
OX NCBI_TaxID=6205 {ECO:0000313|Proteomes:UP000046396, ECO:0000313|WBParaSite:TTAC_0000680701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TTAC_0000680701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM31061.1, ECO:0000313|Proteomes:UP000274429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036578}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116, ECO:0000256|PIRNR:PIRNR036578}.
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DR EMBL; UYWX01020323; VDM31061.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R3X0X0; -.
DR STRING; 6205.A0A0R3X0X0; -.
DR WBParaSite; TTAC_0000680701-mRNA-1; TTAC_0000680701-mRNA-1; TTAC_0000680701.
DR Proteomes; UP000046396; Unplaced.
DR Proteomes; UP000274429; Unassembled WGS sequence.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd17752; BRCT_RFC1; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF6; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR036578};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR036578};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR036578};
KW Nucleus {ECO:0000256|PIRNR:PIRNR036578};
KW Reference proteome {ECO:0000313|Proteomes:UP000274429}.
FT DOMAIN 264..344
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 14..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..929
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..946
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 985 AA; 107644 MW; 4D5B528F2CDF8FC4 CRC64;
IELEVVPRKD VCRKSKRKIP TFEEGEAGED PHRHTERRPP KRRKSTFSSD LGDTEAESPR
GKVQLTFEES LRKAVVKKQV DGTSKSSKTL HDFFPGTEST VKSKKEISVE DYFASSSYKS
PSRVKEPVSL VPETPPTHQD IMKMDEDEIC LSASMAGKPL MPSPAVLRKE KRHSVNTMKD
RSVARDVTKA AQVNTTYLHE LPVASSGTTT PKKKLEPPSS TPTKKKSPST TTPKQASSSG
RASFWKFQNR EGPQALGSRP IPKNTSTCFV GKTFVITGVL ECIEREEAER LIERGGGRVT
QAVSKRTSYL IVGRDSGASK LNKAVSLGTP QLSEDAFFDL VDRGFSKVEA DEGDNDTNDN
AFTLAPSCTI SGRLLTPSPK KSKKVKGESK QPVLLTDRPM VQSLSPTKTA ATEPPVQELW
VEKYRPRTRK ELVGQNGAAS PANRLYAWLS SWQDDYAIGQ KAKPYLSAPP WAAGGSSDKG
AWARAALLSG PPGVGKTSTA LAVCAELNLA TIELNASDTR SKRSLQEEVA NALNMRSLTT
ASSAKSLLLT SHVLIMDEVD GMAGNEDRGG VQELIGIIKT SKVPIICLCN DRQSPKIRSL
ANYCLDLRFH RPRVEQIKAA VLSMVCREGV NVINSVQMWC MNGDHHKTSA TEADITANAA
ASHKYLRLGP FDVIRKVFAP YIDGEPVSFA EAIDLFFQDY SVGPLFVQEN YLSVRPMAAN
GNAQITLDLL AEAAVDIAQG DIVGRAIQST GSWSLLPTQA VFASLRPGRL LRGSLPGGPG
AISSPAWFGR NSTQMKNARL LAELSQHMRI STHGGAADSR SLLLDYLHPL AVRMSAPLKE
GDINSVLEFL EAYQLLREDM DNLMSLTTWL GRPGLMKNID AKVKSALTRT YNKTAHKVPY
GTELVGGGMK KRRKQEEASS EATLAEGDED NPHLEDESEE SSVEEEEEIW KMAKVKTVTK
SCPEPTKEKP TKKPSGNGRR TKKAT
//
