ID A0A0R3X940_HYDTA Unreviewed; 901 AA.
AC A0A0R3X940;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=TTAC_LOCUS10050 {ECO:0000313|EMBL:VDM35030.1};
OS Hydatigena taeniaeformis (Feline tapeworm) (Taenia taeniaeformis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Hydatigera.
OX NCBI_TaxID=6205 {ECO:0000313|Proteomes:UP000046396, ECO:0000313|WBParaSite:TTAC_0001006501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TTAC_0001006501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM35030.1, ECO:0000313|Proteomes:UP000274429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYWX01021272; VDM35030.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R3X940; -.
DR STRING; 6205.A0A0R3X940; -.
DR WBParaSite; TTAC_0001006501-mRNA-1; TTAC_0001006501-mRNA-1; TTAC_0001006501.
DR Proteomes; UP000046396; Unplaced.
DR Proteomes; UP000274429; Unassembled WGS sequence.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR CDD; cd17753; MCM2; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF12619; MCM2_N; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000274429};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 457..663
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..50
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 901 AA; 100869 MW; 9018973A4A5EFE0F CRC64;
MSSDRSSSRS LARDHENGSP DEDLPFEDES AAILGDEDDV QEESEGEDLF RDDMERDYRP
IPELDVYEPE GLASTDDYSS MSPTARAEAE RAMRDRDRAE ALATGVLRRG LVADLYGVDE
EEEIPARRRR LAERVASGLD LEPSGDYEEA LESIENLEDM HGMAVNEWVQ QPATRQEIKN
RFKSFLRTFL DEHGVNVYAE RIVQMARENR QCLSVDYQHL AAAEQVLAYF LPEAPFHVLE
IFNEGALEVT LARYPRYDRI SSHVNVRIVD LPLIEDLRSL RHLHLNQLVR TSGVVTSASS
VMPQLSVVRY NCVKCSCVIG PFVQNQLSNE VKPTLCSECQ STGPFEINLE KTVYKNYQRI
TIQESPGKVP PGRLPRSKDA ILLGDLVDSC KPGDEVELTG IYTNNYSGSL NVQTGFPVFS
TVIHANNVIR KEDKLVLGSL TDEDVKTITK LSRDERIAER IFASIAPSIY GHDDIKRGIA
LALFGGEAKN PGEKHKIRGD INVLLCGDPG TAKSQFLKCV EQLAPRCVFT TGQGASAVGL
TAYVTRNPTS KEWTLEAGAL VLSDRGVCLI DEFDKMNDQD RTSIHEAMEQ QSISISKAGI
VTSLQARCSV IAAANPIGGR YDPSLTFADN VDLSEPILSR FDVLCVVRDT VDSVQDEMLA
KFVVGSHMRH HPNLSLEESE TLVTQLAGLG ATMGSVDGNV GDREPLRQDL LKKYIMYAKD
RVHPKLNQMD QDKVAKAYAD LRRESMATGS IPITVRHIES VVRLSEAHAR MHLREYVNED
DVNMALRIVL ESFVSTQKYG IMKTMRQKFS RFLSYRRDNQ ELLLFLLKQL VHEHSAFERS
RHAAAAGVAE TSLQVEVSEQ ELLDRARQVN IPSVRAFITS ELFVAHHFTY DAGRKLIIHN
L
//
