ID A0A0R4IBQ5_DANRE Unreviewed; 833 AA.
AC A0A0R4IBQ5; A0A8M1PAJ2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Protocadherin 20 {ECO:0000313|Ensembl:ENSDARP00000130343, ECO:0000313|RefSeq:NP_001338645.1};
GN Name=pcdh20 {ECO:0000313|Ensembl:ENSDARP00000130343,
GN ECO:0000313|RefSeq:NP_001338645.1,
GN ECO:0000313|ZFIN:ZDB-GENE-091204-115};
GN Synonyms=si:dkey-27i16.3 {ECO:0000313|RefSeq:NP_001338645.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000130343};
RN [1] {ECO:0000313|RefSeq:NP_001338645.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001338645.1};
RX PubMed=23559552;
RA Melvin V.S., Feng W., Hernandez-Lagunas L., Artinger K.B., Williams T.;
RT "A morpholino-based screen to identify novel genes involved in craniofacial
RT morphogenesis.";
RL Dev. Dyn. 242:817-831(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000130343, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000130343};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000130343}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000130343};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001338645.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001338645.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR628381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001338645.1; NM_001351716.1.
DR RefSeq; XP_697243.3; XM_692151.6.
DR PaxDb; 7955-ENSDARP00000074976; -.
DR Ensembl; ENSDART00000164749; ENSDARP00000130343; ENSDARG00000101910.
DR Ensembl; ENSDART00000164749.2; ENSDARP00000130343.1; ENSDARG00000101910.2.
DR KEGG; dre:568796; -.
DR AGR; ZFIN:ZDB-GENE-091204-115; -.
DR ZFIN; ZDB-GENE-091204-115; pcdh20.
DR eggNOG; ENOG502QWAY; Eukaryota.
DR OMA; EHQNQTM; -.
DR OrthoDB; 4259465at2759; -.
DR PhylomeDB; A0A0R4IBQ5; -.
DR Proteomes; UP000000437; Chromosome 14.
DR Bgee; ENSDARG00000101910; Expressed in caudal fin and 11 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 7.
DR Gene3D; 2.60.40.60; Cadherins; 7.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF276; PROTOCADHERIN 20; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 7.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001338645.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..833
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001338645.1"
FT /id="PRO_5035035735"
FT TRANSMEM 781..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..116
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 117..222
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 239..436
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 437..538
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 539..642
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 646..758
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 833 AA; 92647 MW; 63868ADB41C1F47D CRC64;
MNWKTLQWVL LLACAGQIHS LALRFSVLEE QEAGLKIGTL STNYSAPYRL LNERYIRVDE
ITGDLFTKDR LDRETLCPSH QDGECTFLNT AVVSPHLDVV PMVIVVNDIN DNAPVFERNE
IPLRIPEDTS IGTTFLLDDQ AQDKDTANNG LIHYHLEGSN GFFGIRQEDY GLELIVQKEL
DRETQDNYFL VLVAVDRGSM PLSATANLSV TVTDVDDNCP EFDDDSPIKA IVPGLGIKGT
AVAQLKATDK DLGQNAQITF SFSRQISDRA KTLFYMDRHT GLISLAVDVH TDSPEEHMLK
VFANGPLCPP AQAQVTVYIQ PMVSSEPTIK IRFVTEHKNQ VIMLQENEPP TVLALLELED
TSSDKGTLSL ETDSMPFSLK QQAGSYLLST SKALDFELCG EYDVTVVISD PHGARLHGRE
VIKVVVQDLN DNAPKFEQTR YETDIKENNK PGEFLLKVQA TDADSHQFGK VEYRITNGSP
FRIQEETGVI LVTEPLDREQ QGTYILTVLA QDGGDPSQEA FAIVFVNVLD MNDNPPAFPT
PHFYFFVSES LPHLSQVGKV TVSDADDGDN GRIVDLRILN DKAPFVIDMS QGMLRSTGEV
DREKQDRYEL LVVAVDGGSP VLSTTVKMTV FVEDINDNQP QVLLPSSNLS CLTISPATQA
GSMITKIYAI DEDSGMNSDI TYQIIASEPA LQSPFQIDQH SGNITLVQHL RGEDYGMHHL
FIVVRDGGKP DPLQTTIWVN LLVNETLEKC HVNAVPEYSP QTLPTSMPLS VRGSRCESNS
WLIFLCGLGL MVMSVFILLV SVVVFLKHKK TRRKMEKKDV WESKNICELK PLN
//
