ID A0A0R4ID51_DANRE Unreviewed; 722 AA.
AC A0A0R4ID51; A0A8M3B0Y7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Aryl hydrocarbon receptor nuclear translocator 2 {ECO:0000313|Ensembl:ENSDARP00000131846, ECO:0000313|RefSeq:XP_009301215.1};
GN Name=arnt2 {ECO:0000313|Ensembl:ENSDARP00000131846,
GN ECO:0000313|RefSeq:XP_009301215.1,
GN ECO:0000313|ZFIN:ZDB-GENE-001207-3};
GN Synonyms=Arnt {ECO:0000313|RefSeq:XP_009301215.1}, arnt2a
GN {ECO:0000313|RefSeq:XP_009301215.1}, arnt2X
GN {ECO:0000313|RefSeq:XP_009301215.1}, chunp6921
GN {ECO:0000313|RefSeq:XP_009301215.1}, zfARNT2
GN {ECO:0000313|RefSeq:XP_009301215.1}, zfARNT2a
GN {ECO:0000313|RefSeq:XP_009301215.1}, zfARNT2b
GN {ECO:0000313|RefSeq:XP_009301215.1}, zfARNT2c
GN {ECO:0000313|RefSeq:XP_009301215.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000131846};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000131846, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000131846};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000131846}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000131846};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_009301215.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009301215.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX936312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01029565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FO082028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009301215.1; XM_009302940.3.
DR Ensembl; ENSDART00000167323; ENSDARP00000131846; ENSDARG00000103697.
DR Ensembl; ENSDART00000167323.2; ENSDARP00000131846.1; ENSDARG00000103697.3.
DR GeneID; 64277; -.
DR AGR; ZFIN:ZDB-GENE-001207-3; -.
DR CTD; 9915; -.
DR ZFIN; ZDB-GENE-001207-3; arnt2.
DR OrthoDB; 2872674at2759; -.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000103697; Expressed in swim bladder and 48 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18947; bHLH-PAS_ARNT; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23042:SF6; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR 2; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0R4ID51};
KW Receptor {ECO:0000313|RefSeq:XP_009301215.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 63..116
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 134..206
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 342..393
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 79135 MW; 4D9EC53D47BD9DEE CRC64;
MATPAAVNPS EMGTDLPGPV SMPGAVVGAG QVRMTGAMPG RGGKRRSAGM DFDDEDGEGP
SKFSRENHSE IERRRRNKMT QYITELSDMV PTCSALARKP DKLTILRMAV SHMKSMRGTG
NTSTDGAYKP SFLTEQELKH LILEAADGFL FVVAAETGRV IYVSDSVTPV LNHPQSEWFG
STLFEQVHPD DVDKLREQLS TSENSMTGRI LDLKTGTVKK EGQQSSMRMC MGSRRSFICR
MRCGSAPLDH ISLNRLSSMR KRYRNGLGPS KEGEAQYSVV HCTGYIKAWP PAGMTIPDED
TEAGQTSKYC LVAIGRLQVT SSPVSMDMNG LSVPTEFLSR HNSDGIITFV DPRCINVIGY
QPQDLLGKDI LEFCHPEDQS HLRESFQQVV KLKGQVLSVM YRFRMKNREW MLIRTSSFTF
QNPYSDEIEY IICTNTNVKQ LQQQQQAELE VHQRDGLTAY DLSQVPVSGV SAGVHESGKS
IDKTESLFSQ ERDPRFSDIY TGISTSEKKM MVPSSTSGGQ QLYSQGSPFQ PGHSGKSFSS
SVIHVPGVND IQSTAGSAGQ NLSQISRQIN TGQVSWSGNR PPFSGQQIPA QSNKAQSSPF
GIGSSHSYQA DPSSYSPLSS PATSSPSGNA YSNLANRNTA FDVSGESSQS GGQFQGRPSE
VWSQWQSQHH SQQAGDPHPH TQASQTEVFQ DMLPMPGDPT QGTTNYNIED FADLGMFPPF
SE
//
