ID A0A0R4IDF6_DANRE Unreviewed; 2723 AA.
AC A0A0R4IDF6; A0A8M9Q6G9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Neurobeachin-like 1 {ECO:0000313|Ensembl:ENSDARP00000131170};
DE SubName: Full=Neurobeachin-like protein 1 isoform X1 {ECO:0000313|RefSeq:XP_021332659.1};
GN Name=nbeal1 {ECO:0000313|Ensembl:ENSDARP00000131170,
GN ECO:0000313|RefSeq:XP_021332659.1,
GN ECO:0000313|ZFIN:ZDB-GENE-130530-544};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000131170};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000131170, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000131170};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000131170}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000131170};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_021332659.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021332659.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CU693471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FO082877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FO905046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009300392.2; XM_009302117.2.
DR RefSeq; XP_021332659.1; XM_021476984.1.
DR STRING; 7955.ENSDARP00000131170; -.
DR PaxDb; 7955-ENSDARP00000025827; -.
DR Ensembl; ENSDART00000170351; ENSDARP00000131170; ENSDARG00000099547.
DR Ensembl; ENSDART00000170351.2; ENSDARP00000131170.1; ENSDARG00000099547.2.
DR KEGG; dre:100332617; -.
DR AGR; ZFIN:ZDB-GENE-130530-544; -.
DR ZFIN; ZDB-GENE-130530-544; nbeal1.
DR eggNOG; KOG1787; Eukaryota.
DR OMA; IVFKVME; -.
DR OrthoDB; 5478899at2759; -.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000099547; Expressed in early embryo and 20 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF115; NEUROBEACHIN-LIKE PROTEIN 1; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF16057; DUF4800; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0R4IDF6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1913..2010
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2021..2313
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2517..2558
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 755..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1314..1436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1346..1369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1409..1430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2723 AA; 305883 MW; 14E7F577BAE5B11E CRC64;
MASTERLYEV WMLYCSKKDP DYLKLWLEIF IGSYERCLDV DFEKPPSRSE ETPPVMTLLP
DNILQVLRLQ LLQCVQKASE GLEPEQQTLA LLLLKFLIVI CRNLSNVEEI GACSYINHII
NMTTLYIQQL KSKTKEKELA DQTQAEEFVR HALAFCESLY DPYHNWRHRI HGQQLSTAER
SRQKFKAAAL TVEFVPFFYQ CFQESEHLKD SLKCCLLHLF GAIVAGGQRN ALLAISPATM
EVLMGVLGAG ECLSGGGDGE DWDSEAPDRK ALLTLGCLRE VVHRLLASSS DQRQVEISSV
LESYFKLLNS DPAAAAQVKG RPAPPRSRHW ESRFVALQVN MLETIQDMFE CSDRPVLQAI
FLNSNCFEHL TRLLQNSKLV NARCTTADKD QKDLTNRLLT GESEIQVFQG RLDSLAVATI
KTLTTVMLKS PAAKEVFKER IGYTHLYEVL VSLGQPSRHL LKELMNMAVE GEHSSVGLLG
ISNVDPLLLL IHWLPELDSA ELQIFTADWL RRICGLNRRT RATCVNSCMT AVVLSALERH
QRLHRACAES LVALLGSLGS QSLSSSELQL LLRLLRQDEP GRAHPYVGPV LCSLLGMVRK
QGLESAMQYF DLSPPMAGIA VPTILRWPGS AFSFFAWLSL DQDQLGPPSK GEKRKQLYSF
FTPGGTGFEA FISSAGVLVV AVCTKKEYVT VMLPDYCFCD SLWHSIGVVH VPGKRPFGQS
LVYIFVDGQQ KLSAPLKYPT MTEAFTSCCI GSAGHRTTTP PPSQIPDPPF SGAHPSGRSS
FGTILPGWGG LLGTKPESVT KLISAGTQDS EWGSPTSLQG QLGSVMVFHE PLQATHVKAL
CSAGPNCISA FRSQEAELGE LAPKLLLHYS PKACRNPICL DLSPNLLHGR LTGNKVVNWD
IKDMINCVGG IPVLLPVLEQ LTLLNPDSNP VEPSGSEFIS PDSATPADGD WVILPSNRAS
EARLEKNLVA TFLLVIKHFL QRHPINQETL LHSHGVATLG ALLQKLPAFL VDVSVLVAVQ
LLIEQMTYEK NTQLLLQLHT HLLFNFNIWN QGDFPLRIGH IQYTSTVIKD SRKQFRKKYG
VQFLLDTIRL HYGSGSKDAD LSEDDIKTIR ASLYGLLKYY ISKGTTQEEI QSILGYIAAI
GDEEQLCGVL DLLLTLLQTS AARDQLFLLL FEPGAAESCY ALLLSNKHSD RLRELIFKLF
ERMLKCDRVY EKSKQRLRLR DVGYSGLSLL FSDLHLTSTL IKCLLHQVLS TDTVVNYKDL
MAVVQLTHKA GPSVRLTVCK RLYTLLQSQP DAALQISKQV CWQGTLMRLF VRSPGSDGGS
GRGDAASLGS LELSRSSGGN RLEPPLERRP LGDSVNRLNE ERDSVSDSRS IDSLDNGELM
SLSDTPVEAH TPKTWPGKAG VLSLDLSQLD RGDSGSQTPG SMQSTPSPLE NAKPFPGASS
LNDDNFLFSD NVSLGESFNS ERTEEELSRV LLEVVLCVMW RGVEGSDDSA WLDRGQVFSA
LTKLGTANEL LLPVDHIKLS LMERMLEWAV TDNREASAVT LPQHTENAVR LLHVVQDFLQ
AEGLVNPALW TEKLLEETVT LMDGLMVWYA SGTQWLQLSQ VGLRLLLGFM AQEDPQVCAM
ATAKLNGILQ TKTVNSQDEA CYLLGRVEGI LRRSLSEERI EDTYSFLVPL LRTLLSKIHK
LLYMELHLPS LPNTNGSPSF FEDFQQYVTS PEWRVYLDKY IIPYMKQYEI ETFSQGHENM
ALYWKDCYEA FMLNLHRRDR DRGESKIRFQ EQFVEPFSRR GRQENLRYNS MLKQMHTQNS
GVLRQWRAAR RGLFCERGPW VDKQLKDIHW KLSSAENYSR MRLKLVRNYN FDTHREASAL
RDNLGVQHQQ VNAESLLLEA VKQVKVSDLE DDILELLEED PASANQADSE EAGQKEKLVI
SEDCELVTVV DVYPGRLELT TQHIYFYDSS AEKEEGVGQD FKWPLSQIRE IHLRRYNLRR
SALEIFLIDQ TNYFLNFKKE VRNTVYSRML LLRSLSLHAT HSPQELLKSS GLTQKWVNRE
ISNFDYLMQL NTIAGRTYND LAQYPVFPWI LSDYTSEELD LSDPRVFRDL SKPVAVQNER
NAKAVREKYE SFEDPTGTID RFHYGTHYSN AAGVMHYLIR VEPFTSLHIQ LQSGRFDCAD
RQFHSIPATW QTLMDNPNDV KELIPEFFYF PEFLENQNGF DLGRLQISKE RVNDVILPKW
AKSPEDFIYK HRKALESEFV SAHLHEWIDL IFGYKQRGPA AVEALNVFYY CTYEGAVDLD
AITDEKERKA VEGMISNFGQ TPCQLLKDPH PVRLSLEELE KRRTRLDSCP LNIFEQLTEL
KSFFIEGISD NVPLVKAVVP KNQSHSFISQ GSPDALVTLS QNCLMGTHGW LPYDKNISNY
FTFIKDPTVT SPKTQRFLSG PFSPGVDVTA HLFVVSHDGK LLFSGGHWDN SLRVTSLVKG
KTVGQHIRHM DIVTCLATDH FGIHLISGSR DTTCMVWQVL QQGGAPVGLS HKPVQVLYGH
TDEVVSVSIS TELDMAVSGS RDGTVIIHTV RRGQYMRSLR PPCESSLPLS IMHLAVSWEG
HLVVHTCIEG KATLKDKNAL HLYSVNGKHL CSSSLKEQVT DMCVSGEHVV IGSEQGFLSV
RDLYSLSLCV SPMAMRVPIR CVSVTKEQSH VLVGLEDGKL IVVGVGKPAE MRSGQITRKL
WGSSKRLTQI SSGETEYHTQ EQP
//
