ID A0A0R4IFE9_DANRE Unreviewed; 639 AA.
AC A0A0R4IFE9; A0A8M3B3Y4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Netrin 4 {ECO:0000313|Ensembl:ENSDARP00000132076};
DE SubName: Full=Netrin-4 isoform X1 {ECO:0000313|RefSeq:XP_009301345.1};
GN Name=ntn4 {ECO:0000313|Ensembl:ENSDARP00000132076,
GN ECO:0000313|RefSeq:XP_009301345.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050310-1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000132076};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000132076, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000132076};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000132076}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000132076};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_009301345.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [4] {ECO:0000313|RefSeq:XP_009301345.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; CABZ01018576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01018577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01018578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU571321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009301345.1; XM_009303070.3.
DR STRING; 7955.ENSDARP00000132076; -.
DR PaxDb; 7955-ENSDARP00000105731; -.
DR Ensembl; ENSDART00000165680; ENSDARP00000132076; ENSDARG00000102066.
DR Ensembl; ENSDART00000165680.3; ENSDARP00000132076.1; ENSDARG00000102066.3.
DR GeneID; 561440; -.
DR AGR; ZFIN:ZDB-GENE-050310-1; -.
DR CTD; 59277; -.
DR ZFIN; ZDB-GENE-050310-1; ntn4.
DR eggNOG; KOG0994; Eukaryota.
DR OMA; NNCQHNT; -.
DR OrthoDB; 2916807at2759; -.
DR Reactome; R-DRE-373752; Netrin-1 signaling.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000102066; Expressed in tail and 17 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0043256; C:laminin complex; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0070831; P:basement membrane assembly; IBA:GO_Central.
DR GO; GO:0048514; P:blood vessel morphogenesis; IMP:ZFIN.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IBA:GO_Central.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03578; NTR_netrin-4_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR035811; Netrin-4_NTR.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF419; NETRIN-4 ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 75..293
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 363..424
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 425..470
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 516..638
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 392..401
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 444..453
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 639 AA; 70706 MW; E2577763FE920F1D CRC64;
MKSCSYMQSE GLRSGVGFPC LLWIKPLMLL DTRNLWICVC FSSPGLMSTM ELTGRCVLLA
ALVMSVPHHA CSGCVNRVCN PRMGNLAVGR PIQTVSQCGS TSPEQFCMYR PDSCVLDCEI
CDASVSQHAH SPSSMTDSPF KQPLTWWQSA PGTAIETLQL DLEVEFYFTH LIIIFMSPRP
AAMAIDRSRD FGQTWSLLML FSHNCSEVSS LEDGQRCTAK YSSAEPCTNG EVIYRALSPY
ERLDPYSTDA RSLLGVTNVR IRLLQPHSCP CPIADANAAT PRYAISDLIL KGGCLCHGHA
DQCVPTGGKH NSKTFGKHVV HGKCLCRHHT AGDHCERCHR LYNDRPWRAA DGLTGEANQC
VECKCNGHAE SCHFDESVWL RSGQQHGGVC DCLHNTTGQH CQHCQSGFYR DPEKPSTAPD
SCTPCMCNHV GSSYCKPDNG ECVCKPGVAG RHCEQCMLGY WGLDEYGCKP CQCAGDCDPY
TGDCMIRSES DDNSTAENHL FRTEELFSAL SHPDKCICKQ QALGNSKVFC NAKYAYAVKV
RVLGAHDKGS HAEVDVKILK VLWDNTRLRL SRGSRTLYPE SWMSRGCTCP VLFPGLEYLV
VGHEDVRKGR PVVNMKSIVK PWRASLSRKV HQLLKTKCS
//
