ID A0A0R4IFJ9_DANRE Unreviewed; 99 AA.
AC A0A0R4IFJ9; A0A8M9PNH8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=C-C motif chemokine 22-like {ECO:0000313|RefSeq:XP_021326439.1};
DE SubName: Full=Chemokine (C-C motif) ligand 39, duplicate 6 {ECO:0000313|Ensembl:ENSDARP00000132580};
GN Name=ccl39.6 {ECO:0000313|Ensembl:ENSDARP00000132580,
GN ECO:0000313|RefSeq:XP_021326439.1,
GN ECO:0000313|ZFIN:ZDB-GENE-131121-128};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000132580};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000132580, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000132580};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000132580}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000132580};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_021326439.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021326439.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR450808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001338140.1; XM_001338104.4.
DR RefSeq; XP_021326439.1; XM_021470764.1.
DR STRING; 7955.ENSDARP00000132580; -.
DR Ensembl; ENSDART00000172643; ENSDARP00000132580; ENSDARG00000105089.
DR Ensembl; ENSDART00000172643.2; ENSDARP00000132580.1; ENSDARG00000105089.2.
DR GeneID; 797669; -.
DR KEGG; dre:797669; -.
DR AGR; ZFIN:ZDB-GENE-131121-128; -.
DR CTD; 797669; -.
DR ZFIN; ZDB-GENE-131121-128; ccl39.6.
DR OrthoDB; 3831835at2759; -.
DR Reactome; R-DRE-380108; Chemokine receptors bind chemokines.
DR Reactome; R-DRE-418594; G alpha (i) signalling events.
DR Proteomes; UP000000437; Chromosome 25.
DR Bgee; ENSDARG00000105089; Expressed in spleen and 19 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR CDD; cd00272; Chemokine_CC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015:SF183; C-C MOTIF CHEMOKINE 3; 1.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
PE 4: Predicted;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..99
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041044096"
FT DOMAIN 33..92
FT /note="Chemokine interleukin-8-like"
FT /evidence="ECO:0000259|SMART:SM00199"
SQ SEQUENCE 99 AA; 10998 MW; 2F3FBC1414B469E1 CRC64;
MKIIMKTALL FAVLCCALLP QPSDGQESAD AANSMCCFGK GSNIKIPLRR LEYFYWTSSR
CPLKHVVFVT IAKKHLCMNP DNEWVQKVIN MKSGSGSSV
//
