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Database: UniProt
Entry: A0A0R4IH08_DANRE
LinkDB: A0A0R4IH08_DANRE
Original site: A0A0R4IH08_DANRE 
ID   A0A0R4IH08_DANRE        Unreviewed;      2634 AA.
AC   A0A0R4IH08;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   05-DEC-2018, entry version 24.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 3 {ECO:0000313|Ensembl:ENSDARP00000133340};
GN   Name=itpr3 {ECO:0000313|Ensembl:ENSDARP00000133340,
GN   ECO:0000313|ZFIN:ZDB-GENE-070605-1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000133340, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000133340, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133340,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000133340}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133340};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
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DR   EMBL; BX784023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001300740.1; NM_001313811.1.
DR   UniGene; Dr.158518; -.
DR   STRING; 7955.ENSDARP00000082552; -.
DR   PaxDb; A0A0R4IH08; -.
DR   Ensembl; ENSDART00000167718; ENSDARP00000133340; ENSDARG00000061741.
DR   GeneID; 794666; -.
DR   KEGG; dre:794666; -.
DR   CTD; 3710; -.
DR   ZFIN; ZDB-GENE-070605-1; itpr3.
DR   GeneTree; ENSGT00940000157078; -.
DR   KO; K04960; -.
DR   OMA; SFYNLMT; -.
DR   Reactome; R-DRE-114508; Effects of PIP2 hydrolysis.
DR   Reactome; R-DRE-139853; Elevation of cytosolic Ca2+ levels.
DR   Reactome; R-DRE-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-DRE-5578775; Ion homeostasis.
DR   Reactome; R-DRE-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR   Proteomes; UP000000437; Chromosome 8.
DR   ExpressionAtlas; A0A0R4IH08; baseline.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0048706; P:embryonic skeletal system development; IMP:ZFIN.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0001501; P:skeletal system development; IMP:ZFIN.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2159   2181       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2193   2213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2225   2244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2251   2271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2277   2305       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2326   2348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2444   2467       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      114    174       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      175    225       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      233    289       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      296    368       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      374    430       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       90    111       {ECO:0000256|SAM:Coils}.
FT   COILED     2046   2067       {ECO:0000256|SAM:Coils}.
FT   COILED     2582   2602       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2634 AA;  301770 MW;  5ABB79AE761A23DF CRC64;
     MSDSASSFLH IGDIVSLYAE GTVNGFISTL GLVDDRCVVE PASGDLENPP KKFRDCLFKV
     YPMNRYSAQK QFWKAKQAKH EKDKIGDMVL LQKLQHAANL EQKQNDAENK KVHGDVVKYG
     SVIQLLHMKS NKYLTVNKRL PALLEKNAMR VTLDGTGNEG SWLFIQPFWK LRANGDNVVV
     GDKVILNPVN AGQPLHASSY ELPDHSGCKE INSVNSNTSW KISLFMMFSD HKDEVLKGGD
     VVRLFHAEQE KFLTCDEYKS KLHVFLRTTL RQSATSATSS NALWEVEVVH HDPCRGGAGH
     WNSLYRFKHL ATGNYLAAEE NPGYKENSND IEVDSSRIKR SLGERIKYKL VAVPHGNDIA
     SLFELDPTTL QKTDSFVPRN SYVRFRHLCT NTWIQSTNIP IDIDEERPIR LMLGTCPTKE
     DKEAFAIVSV PVMEIRDLDF ANDASLMLST VVEKFKYGFL SPNDRRYAIK LLEDVVFFVV
     DQLNNGQPAL EVSMNKPNRE RQKLMREQNI LKQIFGIIKA PFKERGDDPP LLTLEELSDQ
     KYLLYQYMLR LCYRVLRHSQ EDYRKNQEYI AKQFGMMQSQ IGYDILAEDT ITALLHNNRK
     LLEKHITKTE VETFVSLVRK NREPRFLDYL SDLCVSNNVA IPVTQELICK CVLNAKNQDI
     LMKTERRAAK ESQHTSEYLE EFGDEDEVWL IWSEKENENH EKSIRQLAQE ARQGNVHDEN
     VLTYYRYQLK LFARMCFDRQ YLAIDVISKQ LDIELISLCM MDETLPFDLR ASFCRLMLHA
     HVDRDPQELV TPIKFARLWT EIPTSISIKD YDSHLDYSRD NKKNKFANTM AFMEEYLNNV
     LIDDLPFANE EKNKLTYEVV SLARHLIYFG FYSFFELLRL TRTLLGIIDC TPSNASINPL
     FNDDGSGKNV RRSIHGMGQM MSTMVLNRKP SLFSAPGRTG DSQVGSKDSI DTQDITVMDT
     KLKILEILQF ILSVRLDYRL SFLLSVFKKE FVDVYPMEDA DATHHTEHEA SINLQHIGEQ
     AEAMFGIGKG NSILEVDDEG GRMFLRVLIH LIMHDYPPLV SGALQLLFKH FSQRQEVLHT
     FKQVQLLIST QDVDNYKHIK RDLDLLRTMV EKSELWVIKK SSSGGDGKKD KKDKKEPEAV
     SPEEEADSKK QTTEKSNESY QNVKEILERL NKMCSSGVFK KQQRLLKNMG AHKVMLDLLQ
     ISYDRNDTKM LEIIKYTHLF LQKFCTGNLE NQALLHKHLN LFLTPRLLEA ETMQQIFSNN
     FQLCSEISES VLHHFIHCLA TQGRHIQYLN FLHTIIKAEG KYVKKCQDMI MTELTSAGDD
     VVVLYTDDTS FNTMVELMTQ SREGVKDDSP LRYHISLVEL LAACAEGKNV YTEIKCTSLL
     PLEEMVKVIT HEDCITEVKI AYVNFVNHCY VDTEVEMKEI YTSNHIWKLF ENFTVDMARV
     CSNREKRMSD PVLEKYVIQV VLDTVTAFFS SPFSENSTST EAHHTTVKQL LQSTMRLLDC
     PWLQPQQKVQ VESCIRTLAV TTKSRSIPLP VELEAHVNMM LSHSNSLTLS RSSHSNKSMS
     RLTRPAAPTN PWDYKNIIEK LQDIINTLEE RVMPLVNAEL SVLVDVLHQP ELLFLEGTDA
     RSRCESGGFI SKLIQHTKAL MNSDEKLCIK VLRTLQEMLI RELDFDEKGF ALRKVLLQNY
     LYNNKKNIKA ELVEHAGGAE GERDWLTVAA LQCRLDKEGG TKLFTDLITS TKNEKIFQES
     IQLAICLLEG GNTEIQNSFY KLMMGDNKSE KFFKVLNDRM KNAQLDIKST VSVNVGEMSN
     KAKDDKDLET GGVSSFGQPE PQPEQQEVET EMGPSVTIMK PILRFLQLLC ENHNQDLQNF
     LRIQNNKTNY NLVSETLQFL DIMCGSTTGG LGLLGLYINE NNVELITQTL ETLTEYCQGP
     CQENQTCIVS HECNGIDIIT ALILNDISPL CRYRMELVLQ LKDNASKLLL ALMESRHDSE
     NAERILFNLR PRELVELIKK AYLQEGECKE GEVSPREVGH NIYILALQLA RHNKVLLTLL
     KPVKKIKEEE EESISSMLNL NKQQEEEKED PLEHYDRQTA QIEIVREDRS MEQIVFPVHP
     ICEFLTEESK FRVFTTTEQD EQGSKVTNFF EQTSFLHNEM EWQKKLRSMP VLYWFSRRMS
     LWGTISFNLA VFINLIIALF YPHDSGHSGS IDSSLLLMGF WCFAGLAVLG LLFKRYGFQS
     LTVAITLRCI YHFGIGPTLL LLGALNLINK IVYLVSFVGN NGTFIMGYKA MVMDVEFLYH
     VAYVLTSSLG LFVHEFFYSI LLFDLIYREE TLFNVIKSVT RNGRSILLTA VLAIILVYLF
     SIVGFLFLRN DFIMEVDHLA SPAPGDTESF MSSCSSDGID CTEETGLLAP AEDEDNTERA
     CDTLLMCIIT VLNHGLRNGG GVGDVLRKPS KNEPLFPARV VYDLLFYFIV IIIVLNLIFG
     VIIDTFADLR SEKQKKEEVL KTTCFICGLE RDKFDNKTVS FEEHIKLEHN IWNYLYFIVL
     IREKNKTDYT GPESYVALMI KNKNLDWFPR MQAMSLVVTD GDGEQNEMRN LQDRLSSTMK
     VVTQLTSQLT ELKEQMTEQR KRRQRMGFVD VQSGSNPGMP VPPSPAGGNQ VYKA
//
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