ID A0A0R4IJ94_DANRE Unreviewed; 424 AA.
AC A0A0R4IJ94; A0A8M1N8D6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=FinTRIM family, member 67 {ECO:0000313|Ensembl:ENSDARP00000133898, ECO:0000313|RefSeq:NP_001034808.2};
GN Name=ftr67 {ECO:0000313|Ensembl:ENSDARP00000133898,
GN ECO:0000313|RefSeq:NP_001034808.2,
GN ECO:0000313|ZFIN:ZDB-GENE-060312-27};
GN Synonyms=wu:fb13h06 {ECO:0000313|RefSeq:NP_001034808.2}, zgc:136688
GN {ECO:0000313|RefSeq:NP_001034808.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000133898};
RN [1] {ECO:0000313|RefSeq:NP_001034808.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001034808.2};
RX PubMed=19196451; DOI=10.1186/1741-7007-7-7;
RA van der Aa L.M., Levraud J.P., Yahmi M., Lauret E., Briolat V.,
RA Herbomel P., Benmansour A., Boudinot P.;
RT "A large new subset of TRIM genes highly diversified by duplication and
RT positive selection in teleost fish.";
RL BMC Biol. 7:7-7(2009).
RN [2] {ECO:0000313|RefSeq:NP_001034808.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001034808.2};
RX PubMed=21789205;
RA Boudinot P., van der Aa L.M., Jouneau L., Du Pasquier L., Pontarotti P.,
RA Briolat V., Benmansour A., Levraud J.P.;
RT "Origin and evolution of TRIM proteins: new insights from the complete TRIM
RT repertoire of zebrafish and pufferfish.";
RL PLoS ONE 6:e22022-e22022(2011).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000133898, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133898};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000133898}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133898};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001034808.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001034808.2};
RX PubMed=28476675;
RA Luo K., Li Y., Ai K., Xia L., Zhang J., Hu W., Gao W., Guo L., Qi Z.,
RA Yuan H., Xu Q.;
RT "Bioinformatics and expression analysis of finTRIM genes in grass carp,
RT Ctenopharyngodon idella.";
RL Fish Shellfish Immunol. 66:217-223(2017).
RN [6] {ECO:0000313|RefSeq:NP_001034808.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001034808.2};
RX PubMed=28461211;
RA Luo K., Li Y., Xia L., Hu W., Gao W., Guo L., Tian G., Qi Z., Yuan H.,
RA Xu Q.;
RT "Analysis of the expression patterns of the novel large multigene TRIM gene
RT family (finTRIM) in zebrafish.";
RL Fish Shellfish Immunol. 66:224-230(2017).
RN [7] {ECO:0000313|RefSeq:NP_001034808.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001034808.2};
RX PubMed=30550990;
RA Langevin C., Levraud J.P., Boudinot P.;
RT "Fish antiviral tripartite motif (TRIM) proteins.";
RL Fish Shellfish Immunol. 86:724-733(2019).
RN [8] {ECO:0000313|RefSeq:NP_001034808.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001034808.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX255896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001034808.2; NM_001039719.2.
DR STRING; 7955.ENSDARP00000133898; -.
DR PaxDb; 7955-ENSDARP00000048321; -.
DR Ensembl; ENSDART00000167987; ENSDARP00000133898; ENSDARG00000098820.
DR Ensembl; ENSDART00000167987.2; ENSDARP00000133898.1; ENSDARG00000098820.3.
DR GeneID; 336567; -.
DR KEGG; dre:336567; -.
DR AGR; ZFIN:ZDB-GENE-060312-27; -.
DR CTD; 336567; -.
DR ZFIN; ZDB-GENE-060312-27; ftr67.
DR eggNOG; KOG2177; Eukaryota.
DR OMA; CTGRKNR; -.
DR OrthoDB; 5475497at2759; -.
DR PhylomeDB; A0A0R4IJ94; -.
DR Proteomes; UP000000437; Chromosome 2.
DR Bgee; ENSDARG00000098820; Expressed in spleen and 25 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19769; Bbox2_TRIM16-like; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF38; RING FINGER PROTEIN PSH1 ISOFORM X1-RELATED; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0R4IJ94};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 15..58
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 150..190
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT COILED 263..297
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 424 AA; 47671 MW; 159E08616DA73E11 CRC64;
MAQAGVFLEH DQFNCSICLD VLKDPVTIPC GHSYCKGCIK NYWDQDDYLG IYGCPQCRQS
FAPRPLLGRN TMLADVVEKL KKTGLHAGPA SDPTQAEPGD VECDVCSGTK NKAFKSCLVC
LASYCETHLQ PHYESPAFQK HRLASPSKKM QEQLCSRHDK LLEVFCRTDQ QCICYLCLTD
EHKGHDTVLA TAEMNEKKNA LLEMRRVSQR RIEEREKELA DLRQATQMLT LSAQTALEES
ERVFTELVCS VERRRAEVKE LIRGQERAAV SQAQTLLQQL EQEITELKKR HAELGELSQT
DDHIAFLQNC KSLCAQPVSV ELPSITSEPN FTSVIAAVTE FQSLLEDVCQ GGFVSISEKV
DDVTIIQNTI PKTDLESNTA PVFGQTAQIP FTINVPTISV FPFSSFGSRT QGPRQRLQPR
RRRR
//
