ID A0A0R4IMW2_DANRE Unreviewed; 225 AA.
AC A0A0R4IMW2; A0A8M1P9S6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Methyltransferase-like 23 {ECO:0000313|Ensembl:ENSDARP00000136449};
DE SubName: Full=Methyltransferase-like protein 23 {ECO:0000313|RefSeq:NP_001314968.1};
GN Name=mettl23 {ECO:0000313|Ensembl:ENSDARP00000136449,
GN ECO:0000313|RefSeq:NP_001314968.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-10056};
GN Synonyms=ik:tdsubc_1b12 {ECO:0000313|RefSeq:NP_001314968.1},
GN si:ch73-366l1.2 {ECO:0000313|RefSeq:NP_001314968.1}, xx:tdsubc_1b12
GN {ECO:0000313|RefSeq:NP_001314968.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000136449};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000136449, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136449};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000136449}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136449};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:NP_001314968.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001314968.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METTL23
CC family. {ECO:0000256|ARBA:ARBA00043988}.
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DR EMBL; CU463857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001314968.1; NM_001328039.1.
DR STRING; 7955.ENSDARP00000136449; -.
DR PaxDb; 7955-ENSDARP00000127524; -.
DR Ensembl; ENSDART00000165367; ENSDARP00000136449; ENSDARG00000099516.
DR Ensembl; ENSDART00000165367.2; ENSDARP00000136449.1; ENSDARG00000099516.2.
DR GeneID; 337849; -.
DR KEGG; dre:337849; -.
DR AGR; ZFIN:ZDB-GENE-030131-10056; -.
DR CTD; 124512; -.
DR ZFIN; ZDB-GENE-030131-10056; mettl23.
DR eggNOG; KOG2793; Eukaryota.
DR OMA; FYDPEDF; -.
DR OrthoDB; 91554at2759; -.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000099516; Expressed in mature ovarian follicle and 20 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14614; HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN; 1.
DR PANTHER; PTHR14614:SF130; HISTONE-ARGININE METHYLTRANSFERASE METTL23; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|RefSeq:NP_001314968.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 225 AA; 25044 MW; B3BCC5609DA03B95 CRC64;
MSELSQTLIV KTFTFEGSGN TRSLTVSVPE VLDPQYGMYV WPSAVVLSQY VWMAREELQN
KMVLELGAGV SLPGVVSALC GAAVILSDSA ELPLCLENCR RSCVLNNLSH VHVLGLTWGR
ASPELLSLPP LDLILGSDVF YEPEDFEDVL VTVSFILRRN PHAQFWTTYQ ERSADWSIEA
LLHKWDLKCI NVPLETFEAN KTHLAGSTLP GNHTVQMMII TNNRI
//
