ID A0A0R4IPI8_DANRE Unreviewed; 865 AA.
AC A0A0R4IPI8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Phosphoinositide 3-kinase regulatory subunit 5 {ECO:0000256|ARBA:ARBA00040195};
GN Name=pik3r5 {ECO:0000313|Ensembl:ENSDARP00000138348,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-2308};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000138348};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000138348}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000138348};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000138348}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000138348};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; BX255899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT027640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009300642.1; XM_009302367.2.
DR AlphaFoldDB; A0A0R4IPI8; -.
DR PaxDb; 7955-ENSDARP00000100847; -.
DR Ensembl; ENSDART00000166192.2; ENSDARP00000138348.1; ENSDARG00000102762.2.
DR GeneID; 323588; -.
DR KEGG; dre:323588; -.
DR AGR; ZFIN:ZDB-GENE-030131-2308; -.
DR CTD; 23533; -.
DR ZFIN; ZDB-GENE-030131-2308; pik3r5.
DR eggNOG; ENOG502QV4A; Eukaryota.
DR OrthoDB; 5349388at2759; -.
DR Bgee; ENSDARG00000102762; Expressed in granulocyte and 15 other cell types or tissues.
DR ExpressionAtlas; A0A0R4IPI8; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR GO; GO:0005944; C:phosphatidylinositol 3-kinase complex, class IB; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR019522; PIK3R5/6.
DR PANTHER; PTHR15593; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR15593:SF2; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5; 1.
DR Pfam; PF10486; PI3K_1B_p101; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT REGION 375..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 96459 MW; DD9C217B2807D6BC CRC64;
MQHTSCTEDR IQHALDRCLD GLRPSENLSQ SWSAGWCMNR WSLEELIKRD PDNFLILLQQ
ILRKAREVQQ ECHYELVAPL ALMFESTLLQ MPLCPSSEKV LTEACEVFHG FLAWPEPYCS
VCRNLLSTLH QELRAPGISY HRLVREEQGL ATSSQRSKII TVFLMNPTEV PPEFLSVAEQ
LSSIEVSQRE SCVTLIKHSY QSVLGTKYPL HTINSALQCL SDDELAQIMS SVSDLLESAA
AMVDIAKARK HVEGGLEVLR EKLGIPSSNG KMSDGVLQTL GLPAAKCYTF HWDKDNFDVL
NDILDIESEL TLSQTSESME EDDVDNVDVE DDEYDDLEDV CTDYRASTFS TVSSLSTASK
DSMFSTLSVA SSECSPLSTL SSSSQASGTD SDFCEDLEDD SSSTVSPSKT KNSGRLSKRI
SRFFKPRSSN SLCRAKSLGS PEAKELVVAV RSKRSNSLPQ QVHLRSSDFG FPVIPLSQLQ
YVCYRRRPIL STDDEEGPTG ATLLRVVVFG ADHVAGRLAR AYSSLRKRER DCPHLTKAFR
MKFFFVPVRR DTAPVNSRRS SLQLSASPLK TAISTTDLCV NRMEDSTNDI ANLLGMLDPW
YERNTLSLME LPVNVVCQQT SKIDSDLSEG TGEERLPIFA DLVLYYCRHA ARPALIQLYQ
AEFTLAGGVR RTEVFIHSLE LGHTAGTRAI KAMGAASKRF GIDGDREAVP LSLEITYNRI
HISGRSQKTR TEKSCTSINL QKACRNSEEL DSKMECLRLT MTEVLKRQNS KSKKGYNQQL
TTTEVKVDKV QVSGTCNTTF AVCLDQDEKK ILQSVMRCEV SVCYKPDSST DWTRGRVFSS
QTQLLQPTFC SLLCLPVATF SGPQP
//
