ID A0A0R4IQ14_DANRE Unreviewed; 661 AA.
AC A0A0R4IQ14; A0A8M9QER6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=RING finger protein 214 {ECO:0000313|RefSeq:XP_021332230.1};
DE SubName: Full=Si:dkey-111e8.1 {ECO:0000313|Ensembl:ENSDARP00000136622};
GN Name=rnf214 {ECO:0000313|ZFIN:ZDB-GENE-030131-2439};
GN Synonyms=si:dkey-111e8.1 {ECO:0000313|RefSeq:XP_021332230.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000136622};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000136622, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136622};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000136622}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136622};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_021332230.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021332230.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX465852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX640520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001921525.3; XM_001921490.6.
DR RefSeq; XP_021332230.1; XM_021476555.1.
DR Ensembl; ENSDART00000167694; ENSDARP00000136622; ENSDARG00000094018.
DR Ensembl; ENSDART00000167694.2; ENSDARP00000136622.1; ENSDARG00000094018.3.
DR GeneID; 323719; -.
DR KEGG; dre:323719; -.
DR AGR; ZFIN:ZDB-GENE-030131-2439; -.
DR CTD; 257160; -.
DR ZFIN; ZDB-GENE-030131-2439; rnf214.
DR eggNOG; ENOG502QTPR; Eukaryota.
DR OMA; AGMEPGW; -.
DR OrthoDB; 4174558at2759; -.
DR Reactome; R-DRE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000000437; Chromosome 5.
DR Bgee; ENSDARG00000094018; Expressed in blastula and 21 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15727; RING FINGER PROTEIN 214; 1.
DR PANTHER; PTHR15727:SF3; RING FINGER PROTEIN 214; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 617..658
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 28..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 160..233
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 54..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 74210 MW; 191C54625BB4892F CRC64;
MESEIHTEWS WALEEDLLQN PVSAVTRLDS SPWSSSAGPW STESGFPTVP TPYEESNTFT
VSKETQSQTV QTEDWTGERA TNTNEDWESE IRALVDCTTE LSEQYEALVK QQAAEQEEHN
LHVHNLQKTR DDRNHQYQEF IEKIESLQVK LKLNSSKTTR KNFMVKRQEL TAEKERMEEE
KTRLAQELEG TEKKLKMLIE EQSQEKLSWE QEIADLRVEM ETLCRQAEQA SQTVLQDEIA
ALEMQEKLAL SQVEDWIIDA EKYLNFLRLN PSQQHLLQRQ KWEHNVAIVR NSVVGLKNKY
NENHQLLQRG EQLDSLPLVQ LPSLPPVPTL EMIMNPLQNT SSHPVFNNGL PTTTTSPPII
HPQLHHSVTP PQRATPPLSA PSPQNTPYLP NTIGPQSSHV PKMYGPMTAH LPSPQIPMQT
IGPPPPSSHA PVTAAPHVLH QTHGGPSYAP SVTPASNFAG LKNSHGANFQ PQAAVRLPQT
FMQTTSIRNP SPQPLPSNPA PAGKLDKLLE RLGSHFPQCT RDQLTRVLQQ IKSERGTMAG
MSMDDVTQQV AQRLVQNQRP PPGPIAPPPG ARAFPGSVGP IQRPVVHPPH PMRPHFPPQV
AQVFHTRPPQ SAPRKFCLMC QNPVDTATQY NTNCSHIMHK DCVSVWLKTS KNNSCPFCPS
K
//
