GenomeNet

Database: UniProt
Entry: A0A0R4IQC4_DANRE
LinkDB: A0A0R4IQC4_DANRE
Original site: A0A0R4IQC4_DANRE 
ID   A0A0R4IQC4_DANRE        Unreviewed;      1810 AA.
AC   A0A0R4IQC4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   20-JUN-2018, entry version 17.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=scn4aa {ECO:0000313|Ensembl:ENSDARP00000136666,
GN   ECO:0000313|ZFIN:ZDB-GENE-051201-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000136666, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000136666, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136666,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000136666}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136666};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BX001032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000165478; ENSDARP00000136666; ENSDARG00000113568.
DR   ZFIN; ZDB-GENE-051201-2; scn4aa.
DR   Proteomes; UP000000437; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
SQ   SEQUENCE   1810 AA;  205631 MW;  74A07D3309A9091E CRC64;
     MARLLPPTGT SVFRRFTPES LVEIERLIQE KSTREELEGA EEEPQAPSSD LEAGKCLPMI
     YGDPPGDLLN TPLEDIDPFY KTQKTFIVIS KGNTIFRFSS EPAMFCISPF SIVRRGAIKI
     LIHSYPFCAV VSLQSLYVFT GIYTFEATVK VLSRGFCIGP FTFLRDPWNW LDFMVISMAY
     VTEFVDLGNV SALRTFRVLR ALKTITVIPG LKTIVGALIQ SVKKMIDVMI LTIFALAVFA
     LIGLQLFMGN LRQKCIRWPI LNSTIFDVYN SNMVNDTTLN VTDTFDFKAY INNEENQYFL
     EGSLDALLCG NSSDAGRCPE GYTCMKAGRN PNYGYTSYDN FGWAFLALFR LMTQDFWENL
     FQLTLRAAGK TYMIFFVVVI FLGSFYLINL ILAVVAMAYD EQNEATLAEA RDKEEEFQRL
     LEQLKNQETG SKASLASQKT QSRGSNRTGS LHDLADEDVI KDCNGRIVPR LIVNRVSSNK
     ELSAEEDQKS LSSKHSMQYL DQPKLSKRTA SALSVLTATM EGLEDAQRPC PPGWYKFADM
     FLKWDCCAPW ILFKKWVHFV VMDPFVDLGI TICIVLNTLF MAMEHYPMSP HFEHVLSVGN
     LVFTGIFTAE MVFKLIAMDP YYYFQVGWNI FDSIIVTLSL VELGLANVQG LSVLRSFRLL
     RVFKLAKSWP TLNMLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK SYKDCVCKIS
     EDCELPRWHM NDFFHSFLIV FRILCGEWIE TMWDCMEVAG ASMCLIVFMM VMVIGNLVVL
     NLFLALLLSS FSGDNLSGGD DDGEMNNLQI AIGRITRGID WVKALVASMV QRILGKKPDN
     TKEEGEGDIE LYALNHLDEG KMADGLTNCL SPTLTVPIAR CESDVEEDED SESSDEEDAK
     ATLNDGDSSV CSTVDYQPPE PEPEPEEVEE EEPEPEEPEA CFTEGCIRRC ACLSVDITEG
     WGKKWWNLRR TCFTIVEHDY FETFIIFMIL LSSGALAFED INIERRRVIK TILEYADKVF
     TYIFIVEMLL KWVAYGFKTY FTNAWCWLDF LIVDVSLVSL TANLMGYSEL GAIKSLRTLR
     ALRPLRALSR FEGMRVVVNA LVGAIPSIFN VLLVCLIFWL IFSIMGVNLF AGKFYHCINT
     TTEERIPMDV VNNKSDCMAL MYTNEVRWVN VKVNYDNVGL GYLSLLQIAT FKGWMDIMYA
     AVDSREVDEQ PSYEINLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK SKIRKDIFMT
     EEQKKYYNAM KKLGAKKRPK PIPRPSNIIQ GLVFDFISKQ FFDIFIMVLI CLNMVTMMIE
     TDDQSAEKEY VLYQINLVFI VVFTSECVLK LFALRQYFFT IGWNVFDFVV VILSIAGLML
     SDIIEKYFVS PTLFRVIRLA RIGRVLRLIR GAKGIRTLLF ALMMSLPALF NIGLLLFLIM
     FIFSIFGMSN FAYVKKQAGI DDIFNFETFG GSIICLFEIT TSAGWDGLLL PILNSGPPDC
     DPDFENPGTD VRGNCGNPGM GIMFFCSYII MSFLVVVNMY IAIILENFNN AQEESGDPLC
     EDDFDMFDET WEKFDVDATQ FIEYDRLFDF VDALQEPLRI AKPNRLKLIS MDIPIVNGDK
     IHSQDILLAV TREVLGDTIE MDAMKESIEA KFIMNNPTSA SFEPIITTLR RKEEERAAIA
     VQRIYRRHLL KRAIRYACFM RRSKRKVRNP NDNEPPETEG LIARKMNTLY GSNPELAMAL
     ELETRPMRPN SQPPKPSQVT QTRASVTFPR PQGQLILPVE LTSEVILRSA PITHSLNSSE
     NATTIKESIV
//
DBGET integrated database retrieval system