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Database: UniProt
Entry: A0A0R4IQX8_DANRE
LinkDB: A0A0R4IQX8_DANRE
Original site: A0A0R4IQX8_DANRE 
ID   A0A0R4IQX8_DANRE        Unreviewed;      2082 AA.
AC   A0A0R4IQX8;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   20-JUN-2018, entry version 20.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=cacna1da {ECO:0000313|Ensembl:ENSDARP00000137557,
GN   ECO:0000313|ZFIN:ZDB-GENE-030616-135};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000137557, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000137557, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000137557,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000137557}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000137557};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in
CC       opposite effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; BX248521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX571969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01048890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FQ323136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; LO017922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000168288; ENSDARP00000137557; ENSDARG00000102773.
DR   ZFIN; ZDB-GENE-030616-135; cacna1da.
DR   GeneTree; ENSGT00830000128247; -.
DR   Reactome; R-DRE-422356; Regulation of insulin secretion.
DR   Reactome; R-DRE-5576892; Phase 0 - rapid depolarisation.
DR   Reactome; R-DRE-5576893; Phase 2 - plateau phase.
DR   Proteomes; UP000000437; Chromosome 11.
DR   ExpressionAtlas; A0A0R4IQX8; baseline.
DR   GO; GO:0009925; C:basal plasma membrane; IDA:ZFIN.
DR   GO; GO:0016021; C:integral component of membrane; ISS:ZFIN.
DR   GO; GO:0097470; C:ribbon synapse; IDA:ZFIN.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; ISS:ZFIN.
DR   GO; GO:0050974; P:detection of mechanical stimulus involved in sensory perception; IMP:ZFIN.
DR   GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IMP:ZFIN.
DR   GO; GO:0050885; P:neuromuscular process controlling balance; IMP:ZFIN.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0050808; P:synapse organization; IGI:ZFIN.
DR   Gene3D; 1.20.120.350; -; 3.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
SQ   SEQUENCE   2082 AA;  237178 MW;  52E9384BDACF5EDA CRC64;
     MSANGPAPPA ATPAAPPAAA VPVPSVVPVG SLAQKKRAQY AKSKKQGSSA NTRPQRALFC
     LNLNNPIRRA CISLVEWKPF DIFILIAIFA NCMALAVYVP FPEDDSNSTN HDLETVEYAF
     LIIFTIETFL KIIAYGLVMH QNAYVRNGWN MLDFVIVVIG LFSVVLEVLT KEGGEKEEVG
     ENLSAHGHGG KPGGFDVKAL RAFRVLRPLR LVSGVPSLQV VLNSIIKAMV PLLHIALLVL
     FVIIIYAIIG LELFIGKMHA SCYFQGTDIL EDEPAPCAVN GHGRTCPING TLCKEGWQGP
     NGGITNFDNF MFAMLTVFQC ITMEGWTDVL YWMNDAMGLE LPWVYFVSLV IFGSFFVLNL
     VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEEEESK
     RNRVTLASLM EKKKKGFGWF SQSSDTHASM PASETESMNT ENEKGEDEKA TCCGPTCQKI
     SKSKFSRRWR RWNRLCRRNC RLAVKSVPFY WLVIILVFLN TLTISSEHYN QPMWLTQVQD
     VANKVLLAMF TCEMLVKMYS LGLQAYFVSL FNRFDCFVVC GGITETILVE FEIMSPLGIS
     VFRCVRLLRI FKVTRHWASL SNLVASLLNS MKSIASLLLL LFLFIIIFSL LGMQVFGGKF
     NFDETQTKRS TFDNFPQALL TVFQILTGED WNAVMYDGIM AYGGPSSSGM IVCIYFIILF
     ICGNYILLNV FLAIAVDNLA DAESLNTDDT KKPDEIDEIE DEAKAGEEDE KDNAEEDEEE
     PDVPAGPRPK ISELVKKEKI TPIPEGSAFF IFSNTNPVRV ACHKLINHHI FTNLILVFIM
     LSSASLAAED PIRNFSARNI ILGYFDYAFT AIFTVEIVLK MTTYGAFLHK GAFCRNYFNL
     LDLLVVGVSL VSFGIQSSAI SVVKILRVLR VLRPLRAINR AKGLKHVVQC VFVAIRTIGN
     IMIVTTLLQF MFACIGVQLF KGKFYRCNDE AKSSPEECKG TYIMYKEGDV NQPIIQKRHW
     HNSDFNFDNV LMAMMALFTV STFEGWPALL YKAIDSNREN MGPIYNYRVE ISIFFIIYII
     IIAFFMMNIF VGFVIVTFQE QGEKEYKNCE LDKNQRQCVE YALKARPLRR YIPKNPYQYK
     FWYVVNSTGF EYIMFVLILL NTICLAVQHY GQSELFNYVM DILNMVFTAV FTVEMVLKLI
     AFKPRHYFTD AWNTFDALIV VGSVVDIAIT EVNNTEDSAR ISITFFRLFR VMRLVKLLSR
     GEGIRTLLWT FIKSFQALPY VALLIAMLFF IYAVIGMQVF GKIAMVDHTQ INRNNNFQTF
     PQAVLLLFRC ATGEAWQEIM LACMPGKLCD PESDYNPGEE MTCGSSFAII YFITFYMLCA
     FLIINLFVAV IMDNFDYLTR DWSILGPHHL DEFKRIWSEY DPEAKGRIKH LDVVTLLRRI
     QPPLGFGKLC PHRVACKRLV AMNMPLNSDG TVMFNATLFA LVRTALKIKT EGNLEQANEE
     LRAVIKKIWK RTSMKLLDQV VPPAGDDEVT VGKFYATFLI QDYFRKFKKR KEEGLVGVHP
     AQNNTAIALQ AGLRTLHDIG PEIRRAISCD LQDDELVDFI PEEDEEIYRR NGGLFGNHIN
     HINGDPRRSS GHQTNATQRP LQVQPPPHYV HMEQPVGRLG RANAMAQQNH HRHHHHHHHH
     HHHNNSYNKS PKSTNINLNN ANVSSLPNGG HNRYYEHAPA NGYPGSYYGE YDKPRTPHGQ
     RRRYYETYIR SQGSDRRRPT IRREEEYEED RYSGEYYSGE EFYEDDSMLS GDRYPNSDQE
     YETPRGYHHP DSYYEDDEQP LYHDSHRSPK RRLLPPTPQG NRRPSFNFEC LRRQSSQDDL
     PHQRTALPLH LMQHQVMAVA GLDSSRAHRL SPTRSTRSWA SPPPTPASKD RTPYYTPLIR
     VDRPLRDSAS SSHSSIRKSS WYTDDPEYQQ RNFSPVHLQV PPEYRNQYLQ KRGSATSLVE
     AVLISEGLGR YAKDPKFVAA TKHEIADACE MTIDEMESAA SHLLNGGITP VVNGVNVFPI
     LGHRDYELQD VSASYSDEEP EPEPRPRYEE DLADEMICIT TL
//
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