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Database: UniProt
Entry: A0A0R4IRX1_DANRE
LinkDB: A0A0R4IRX1_DANRE
Original site: A0A0R4IRX1_DANRE 
ID   A0A0R4IRX1_DANRE        Unreviewed;       974 AA.
AC   A0A0R4IRX1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   18-SEP-2019, entry version 26.
DE   SubName: Full=Si:ch73-236c18.7 {ECO:0000313|Ensembl:ENSDARP00000139360};
GN   Name=si:ch73-236c18.7 {ECO:0000313|Ensembl:ENSDARP00000139360,
GN   ECO:0000313|ZFIN:ZDB-GENE-121214-3};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000139360, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000139360, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139360,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000139360}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139360};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
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DR   EMBL; CU914621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000169945; ENSDARP00000139360; ENSDARG00000098706.
DR   ZFIN; ZDB-GENE-121214-3; si:ch73-236c18.7.
DR   GeneTree; ENSGT00970000193387; -.
DR   Proteomes; UP000000437; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRC_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR003877; SPRY_dom.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS01046498};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Leucine-rich repeat {ECO:0000256|SAAS:SAAS01143294};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS01046502};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS01046485}.
FT   DOMAIN      172    306       NACHT. {ECO:0000259|PROSITE:PS50837}.
FT   DOMAIN      785    974       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   REGION        1     47       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   974 AA;  111025 MW;  792EE473F2C7D34F CRC64;
     MSLSKRKGSK MSSASPGSTC VSMKSDQSKN FVSPQINDGT VTSDLSNREI HEQTKLVSSI
     KFNLQTHKKQ ENQETVLKTQ AQETGDLQRV KDKLKTSLKK KYERLFEGNT LQENQTLLNR
     IYTQLYIIEG ESEGVNEEHE VLQMEKTART KHSQHTPIYC NDIFKEEKEQ IKTVLTKGIA
     GIGKTVSVQK FILDWAEGKA NQDVDFMFVL PFRELNLIRD HQYSLHTLLL DFHPELEDLE
     PKIYEECKVV FIFDGLDESR ITLMFSDAQK VCDVTETSSV AVLMSKLMKG ELLPSALIWI
     TSRPAAANQI PSKYIKRLTE IQGFTEPQKE EYFRKRISEQ HQASRIISHI RRARSLHIMC
     HIPVFCWISS TVLQKLLEED LSAEIPQTLT EMYIHFLLIQ INMRNQKYEE RDPEKLLQSN
     REVIVKLAEV AFRQLMKGNV MFYEEDLIES GVDVSDASVY SGICTEIFKE ESVIQQRKVY
     SFIHLSVQEF LAAFYVFYYH VNTTMDGLRN FASVENLLKG AVDKTIESEN GYLDLFLRFL
     LGVSLESNQR LFQDLLTHTE KSSKSIRRST QYIKEKIRDG HGLSTERSIN LFLCLLEVKD
     QTLSREIQEF VKSDKQSEKK LSPAHCSTIA YMLQMSEEVL DELELQKYNT SDEGRRRLIP
     AVSNCTRALL AGCNLSAQDC EIVSSVLQSS NCVLRELDLS NNDLQDSGVK LLSDGLKSPN
     CQLEILRLSG CMVTEEGCGF LSSALSSNPS HLRELDLSYN HPGQSGVQLL QHTLEDPHYT
     LQKLNLDYEG HFRIISGLRK YAVNITLDPN TAHNQLILSD GNKTATHVTD PQPYPDHPDR
     FDQQEQVLCR ETLTGRCYWE VKWSGSGHVG VAYKAIERKS GSNCRFGRNE HSWSLYCCDE
     VYCSWHNNKS DDITAPSSKT NRVGVYVDVP AGSLSFYSVS DTLTLIHTFN TTFTEDIYAG
     FVVYPASSVS LLDI
//
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