ID A0A0R4ITZ2_DANRE Unreviewed; 782 AA.
AC A0A0R4ITZ2; A0A8M3AWH2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Protein VAC14 homolog {ECO:0000256|ARBA:ARBA00013840};
GN Name=vac14 {ECO:0000313|Ensembl:ENSDARP00000138390,
GN ECO:0000313|RefSeq:XP_009296175.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040912-82};
GN Synonyms=fb68e05 {ECO:0000313|RefSeq:XP_009296175.1}, wu:fb68e05
GN {ECO:0000313|RefSeq:XP_009296175.1}, zgc:100945
GN {ECO:0000313|RefSeq:XP_009296175.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000138390};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000138390, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000138390};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000138390}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000138390};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_009296175.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009296175.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004524}.
CC -!- SIMILARITY: Belongs to the VAC14 family.
CC {ECO:0000256|ARBA:ARBA00010225}.
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DR EMBL; AL844894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009296175.1; XM_009297900.3.
DR Ensembl; ENSDART00000167750; ENSDARP00000138390; ENSDARG00000014303.
DR Ensembl; ENSDART00000167750.2; ENSDARP00000138390.1; ENSDARG00000014303.9.
DR GeneID; 447912; -.
DR AGR; ZFIN:ZDB-GENE-040912-82; -.
DR CTD; 55697; -.
DR ZFIN; ZDB-GENE-040912-82; vac14.
DR OMA; CYQHVSE; -.
DR OrthoDB; 5481081at2759; -.
DR Proteomes; UP000000437; Chromosome 25.
DR Bgee; ENSDARG00000014303; Expressed in cleaving embryo and 23 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070772; C:PAS complex; IEA:InterPro.
DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026825; Vac14.
DR InterPro; IPR021841; VAC14_Fig4p-bd.
DR PANTHER; PTHR16023:SF0; PROTEIN VAC14 HOMOLOG; 1.
DR PANTHER; PTHR16023; TAX1 BINDING PROTEIN-RELATED; 1.
DR Pfam; PF12755; Vac14_Fab1_bd; 1.
DR Pfam; PF11916; Vac14_Fig4_bd; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022848};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0R4ITZ2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 543..721
FT /note="Vacuolar protein 14 C-terminal Fig4-binding"
FT /evidence="ECO:0000259|Pfam:PF11916"
FT REGION 334..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 782 AA; 88621 MW; D4F0728B8D7AD4F3 CRC64;
MNTEKDFSPL TPNIVRALND KLYEKRKVAA LEIEKLVREF VAQNNSAQIR HVIQILATEF
ALSQHPHSRK GGLIGLAACS IALGKDSGLY LKELIDPVLT CFNDSDSRLR YYACEALYNI
VKVARGAVLP HFNVLFDGLS KLAADPDPNV KSGSELLDRL LKDIVTESNK FDLVAFVPLL
RERIYSNNQY ARQFIISWIH VLESVPDINL LDYLPEILDG LFQILGDSSK EIRRMCELVL
GEFLKEIKKN PSSVKFAEMA NILVIHCQVS DESKSTNDLI QLTSMTWMRE FIQLAGRVVL
PYSSGILTAV LPCLSYDDRK KSTKEAASAC NHSLMKLVTP EDDEDDEESQ TKSSPPSDEA
PSKKEGDLND SLNESQESVG FSNISFFTPA SSDRSAVTLD LDGIVQVLDR HLHDSSTGMM
TRIAVLKWLY HLYIKTPRKM FKHTDSLFPM LLKTLSDESD EVILKDLEVL AEIASSPAGQ
TDTSGSCDIS DSKTELHIPG GVRDGQPVVV GSKMTDLSPS TPSMNSYFYK FMINLLKRFS
LERKLLEMRG AFIIRQLCLL LHAENIFHSM ADILLKEEDL KFASTMVQTL NTILLTSAEL
FQLRNQLKDL RTQESCALFC CLYRSWCHNP VATVSLCFLT QNYRHAYDLI QKFGDLEVTV
DFLMEVDKLV QLIESPIFTY LRLQLLDVEH NPYLIKALYG LLMLLPQSQA FQLLSHRLSC
VPNPELMRTL EDQKVAVKDK HLAQPHIDYS ELLQHFDRVQ SKHLEVRHQR TGRSEHPDRK
LM
//
