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Database: UniProt
Entry: A0A0R4IUR5_DANRE
LinkDB: A0A0R4IUR5_DANRE
Original site: A0A0R4IUR5_DANRE 
ID   A0A0R4IUR5_DANRE        Unreviewed;      1075 AA.
AC   A0A0R4IUR5;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   18-SEP-2019, entry version 31.
DE   SubName: Full=Si:dkey-217g21.3 {ECO:0000313|Ensembl:ENSDARP00000139859};
GN   Name=si:dkey-217g21.3 {ECO:0000313|Ensembl:ENSDARP00000139859,
GN   ECO:0000313|ZFIN:ZDB-GENE-110913-15};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000139859, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000139859, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139859,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000139859}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000139859};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
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DR   EMBL; CR927050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; A0A0R4IUR5; -.
DR   Ensembl; ENSDART00000164615; ENSDARP00000139859; ENSDARG00000100460.
DR   ZFIN; ZDB-GENE-110913-15; si:dkey-217g21.3.
DR   GeneTree; ENSGT00970000193387; -.
DR   OMA; KHEAHAE; -.
DR   Proteomes; UP000000437; Chromosome 4.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR029495; NACHT-assoc.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRC_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR003877; SPRY_dom.
DR   Pfam; PF14484; FISNA; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM01288; FISNA; 1.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS01046498};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Leucine-rich repeat {ECO:0000256|SAAS:SAAS01143294};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS01046502};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS01046485}.
FT   DOMAIN      267    399       NACHT. {ECO:0000259|PROSITE:PS50837}.
FT   DOMAIN      886   1075       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   REGION        1     49       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION       67    100       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      120    140       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     15     31       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1075 AA;  122406 MW;  DA76A50186AE1025 CRC64;
     MTEERVKDSL SEKHSVRSGS CVSSSVSLKS DWSKEDPPKF SEKTPTSAQR VRWGSCVSSF
     VSLKSACSKE DPPKFSEETP PSAHSVDYEL QDSGDKTHRR HKSFTDNLES IFQNIESKIF
     RFLKNELEKF KKILQEENRQ EFVKDFNENR SRITEAALDL TLFFLREMKQ DQAADTLESE
     LFFINQLKCG MKKKYESVFE GIARQGDSTL LNNIYTDLYI TQGASEQVNT EHEIRQIEAA
     SRRHQSLEIQ VECKHLFEAA EQDEQIRTVL TKGVAGIGKS VSVQKFVLDW AEGKENQDIS
     FIFPLPFREM NLKEKERQSL KDLITQFFPE TKGLNLTRST RFKVLFILDG LDECRLPLNF
     AGNKTCRDVS SAVSLDVLLT NLIKGNLLPS ALIWITSRPV AASKIPADCI NRLTEIRGFN
     DAQKEEYFRK RLTDQNQARE IIDHIKQSKS LFIMCHIPVF CWISATVLQN ILKHEAHAET
     LQESPKTLTQ MYTHFLRVQI QQSRRKYDGE NTPDVSLDPN LILSLGKLAF QQLERNNVIF
     YESNLKDCGI DVDKASVYSG MCTQIFKEET GIILGTMYCF LHLSIQEFIA ALYQHLFLDI
     NKKHGWFFKQ KSRNKAMTDL LKTAVDKALE SENGHYDLYL RFLLGLSLQS NRQLLRGLLT
     QQDDRDQSKE EIIAYIKQKL EGNLSPEKSI NLFYCLNELN DQTLLKEIQS HLSRGSLSSA
     DLSPAQWSAL VFVLLTLEEE LEEFELQKFQ RSDECLIRLL AVIKSSKKAL LHGCKLTVQC
     CESLSSVLQS SNCVLRELDL SNNDLQDSGV KILSDGLKSP NCKLETLRLS GCMVTEEGCG
     FLSSALTSNP SHLRELDLSY NHPGDSGVKL LSEQLEDPNY TLNKLNLDHG GDTRITAGLH
     KYVCFFTLDP NTANTHLILS EENREVKSVR ENQPYPDHPD RFDDYPQVLC RESVCGRCYW
     EIDCSGDDVC ISVSYKSIRR KGAGEKCVFG FNAQSWSLVC SSSSFTFWHN NTHTDLPVKP
     LSRRIGVFVD HSAGTLIFYN IYRGTMSLIH SVQTTFTEPL WPGFGLYSGS SVKLS
//
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