ID A0A0R4IZX1_MOUSE Unreviewed; 630 AA.
AC A0A0R4IZX1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Differentially expressed in FDCP 6 {ECO:0000313|Ensembl:ENSMUSP00000002327.6};
GN Name=Def6 {ECO:0000313|Ensembl:ENSMUSP00000002327.6,
GN ECO:0000313|MGI:MGI:1346328};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000002327.6, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000002327.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000002327.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000002327.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000002327.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_081461.2; NM_027185.3.
DR AlphaFoldDB; A0A0R4IZX1; -.
DR SMR; A0A0R4IZX1; -.
DR EPD; A0A0R4IZX1; -.
DR jPOST; A0A0R4IZX1; -.
DR ProteomicsDB; 348800; -.
DR Antibodypedia; 29495; 459 antibodies from 32 providers.
DR DNASU; 23853; -.
DR Ensembl; ENSMUST00000002327.6; ENSMUSP00000002327.6; ENSMUSG00000002257.9.
DR GeneID; 23853; -.
DR KEGG; mmu:23853; -.
DR AGR; MGI:1346328; -.
DR CTD; 50619; -.
DR MGI; MGI:1346328; Def6.
DR VEuPathDB; HostDB:ENSMUSG00000002257; -.
DR GeneTree; ENSGT00950000183017; -.
DR OMA; EHRCIEL; -.
DR OrthoDB; 5354765at2759; -.
DR PhylomeDB; A0A0R4IZX1; -.
DR BioGRID-ORCS; 23853; 1 hit in 78 CRISPR screens.
DR ChiTaRS; Def6; mouse.
DR Proteomes; UP000000589; Chromosome 17.
DR Bgee; ENSMUSG00000002257; Expressed in thymus and 161 other cell types or tissues.
DR ExpressionAtlas; A0A0R4IZX1; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0098876; P:vesicle-mediated transport to the plasma membrane; IEA:Ensembl.
DR CDD; cd13273; PH_SWAP-70; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14383:SF2; DIFFERENTIALLY EXPRESSED IN FDCP 6 HOMOLOG; 1.
DR PANTHER; PTHR14383; SWAP-70 RECOMBINASE; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A0R4IZX1,
KW ECO:0007829|MaxQB:A0A0R4IZX1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 216..312
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 318..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 73453 MW; 5AA34B3F1F93850B CRC64;
MALRKELLKS IWYAFTALDV EKSGKVSKSQ LKVLSHNLYT VLNIPHDPVA LEEHFRDDDD
GPVSSQGYMP YLNKYILDKV EEGAFVKEHF DELCWTLTAK KNYRADGIGS SPLSNQDAFR
LWCLFNFLSE DKYPLIMVPD EVEYLLKKLL GSLSLEMGLG KLEELLAQDA QSAQTAVGLS
VWQFLELFNS GRCLRGVGRD SLSMAIQEVY QELIQDVLKQ GYLWKRGHLR RNWAERWFQL
QPSSLCYFGS EECKEKRGTI PLDAHCCVEV LPDREGKRCM FCVKTASRTY EMSASDTRQR
QEWTAAIQTA IRLQAEGKTS LHKDLKQKRR EQREQRERRR AAKEEELLRL QQLQEEKERK
LQELELLQEA QRQAERLLQE EEERRRSQHK ELQQALEGQL REAEQARASM QAEMELKKEE
AARQRQRIAE LEEMQERLQE ALQLEVKARR DEEAVRLAQT RLLEEEEEKL KQLMHLKEEQ
ERYIERAQQE KQELQQEMAL QSRSLQHAQQ QLEEVRQNRQ RADEDVEAAQ RKLRQASTNV
KHWNVQMNRL MHPIEPGDKR PTTSSSFTGF QPPPLARRDS SLKRLTRWGS QGNRTLSVNS
SEQKSLNGGD ETPILALASQ EEKLDPAPGN
//
