ID A0A0R4J0K3_MOUSE Unreviewed; 233 AA.
AC A0A0R4J0K3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Synaptogyrin {ECO:0000256|PIRNR:PIRNR011282};
GN Name=Syngr4 {ECO:0000313|Ensembl:ENSMUSP00000047035.8,
GN ECO:0000313|MGI:MGI:1928903};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000047035.8, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000047035.8, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000047035.8,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000047035.8}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000047035.8};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|PIRNR:PIRNR011282}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|PIRNR:PIRNR011282}.
CC -!- SIMILARITY: Belongs to the synaptogyrin family.
CC {ECO:0000256|ARBA:ARBA00010252, ECO:0000256|PIRNR:PIRNR011282}.
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DR RefSeq; NP_067457.2; NM_021482.2.
DR RefSeq; XP_006541097.1; XM_006541034.1.
DR AlphaFoldDB; A0A0R4J0K3; -.
DR SMR; A0A0R4J0K3; -.
DR ProteomicsDB; 347460; -.
DR Antibodypedia; 31700; 154 antibodies from 31 providers.
DR DNASU; 58867; -.
DR Ensembl; ENSMUST00000039049.16; ENSMUSP00000047035.8; ENSMUSG00000040231.17.
DR GeneID; 58867; -.
DR KEGG; mmu:58867; -.
DR AGR; MGI:1928903; -.
DR CTD; 23546; -.
DR MGI; MGI:1928903; Syngr4.
DR VEuPathDB; HostDB:ENSMUSG00000040231; -.
DR GeneTree; ENSGT00950000182935; -.
DR OMA; IWIFQAY; -.
DR OrthoDB; 4177492at2759; -.
DR PhylomeDB; A0A0R4J0K3; -.
DR BioGRID-ORCS; 58867; 6 hits in 80 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000040231; Expressed in spermatocyte and 46 other cell types or tissues.
DR ExpressionAtlas; A0A0R4J0K3; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008253; Marvel.
DR InterPro; IPR016579; Synaptogyrin.
DR PANTHER; PTHR10838; SYNAPTOGYRIN; 1.
DR PANTHER; PTHR10838:SF22; SYNAPTOGYRIN-4; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PIRSF; PIRSF011282; Synaptogyrin; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|PIRNR:PIRNR011282, ECO:0000256|PROSITE-
KW ProRule:PRU00581};
KW Proteomics identification {ECO:0007829|ProteomicsDB:A0A0R4J0K3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR011282, ECO:0000256|PROSITE-
KW ProRule:PRU00581}; Transmembrane helix {ECO:0000256|PIRNR:PIRNR011282}.
FT TRANSMEM 25..42
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR011282"
FT TRANSMEM 62..86
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR011282"
FT TRANSMEM 107..126
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR011282"
FT TRANSMEM 146..165
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR011282"
FT DOMAIN 18..169
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
FT REGION 191..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 233 AA; 25829 MW; 2963D92375496F55 CRC64;
MHLPESLHDL ADNETVRFLR RPKSISRIFG GVFSLVIFSS LLTDGYQNRT ESPQLRCVLN
SNHMACSFAV GAGFLSFLSC LVFLAIDAYE RRLVGTRFKI AFQLLDFILA VLWAGVWFVA
FCFLASQWQH SKSKHFLLGN SSAKAAIAFS FFSVPVWILQ AYLAFQDLRD EAPVPYKRSL
EEGSVVLNTL SPSSTSPSNP PITGPNSLSY TSSALSPYMT TPKAPRLAMM PDS
//
