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Database: UniProt
Entry: A0A0R4J0M1_MOUSE
LinkDB: A0A0R4J0M1_MOUSE
Original site: A0A0R4J0M1_MOUSE 
ID   A0A0R4J0M1_MOUSE        Unreviewed;       341 AA.
AC   A0A0R4J0M1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   05-JUN-2019, entry version 25.
DE   SubName: Full=Tubulin-specific Chaperone C {ECO:0000313|EMBL:EDL23546.1, ECO:0000313|Ensembl:ENSMUSP00000048696};
GN   Name=Tbcc {ECO:0000313|EMBL:EDL23546.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000048696, ECO:0000313|MGI:MGI:1919976};
GN   ORFNames=mCG_53793 {ECO:0000313|EMBL:EDL23546.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000048696, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|EMBL:EDL23546.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed {ECO:0000313|EMBL:EDL23546.1};
RX   PubMed=12040188; DOI=10.1126/science.1069193;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
RA   Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
RA   Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
RA   Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
RA   Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
RA   Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
RA   Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
RA   Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
RA   Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
RA   Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
RA   Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
RA   Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
RA   Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
RA   Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
RA   Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
RA   Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
RA   Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
RA   Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
RA   Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
RA   Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
RA   Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
RA   Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
RA   Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
RA   Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
RA   Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
RA   Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
RA   Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
RA   Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
RA   Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
RA   Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
RA   Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
RA   Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
RT   "A comparison of whole-genome shotgun-derived mouse chromosome 16 and
RT   the human genome.";
RL   Science 296:1661-1671(2002).
RN   [2] {ECO:0000313|EMBL:EDL23546.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed {ECO:0000313|EMBL:EDL23546.1};
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000048696, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000048696,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [5] {ECO:0000313|Ensembl:ENSMUSP00000048696}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000048696};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
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DR   EMBL; AC165289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466559; EDL23546.1; -; Genomic_DNA.
DR   RefSeq; NP_848472.2; NM_178385.3.
DR   Ensembl; ENSMUST00000040434; ENSMUSP00000048696; ENSMUSG00000036430.
DR   GeneID; 72726; -.
DR   KEGG; mmu:72726; -.
DR   CTD; 6903; -.
DR   MGI; MGI:1919976; Tbcc.
DR   GeneTree; ENSGT00940000162058; -.
DR   KO; K21766; -.
DR   OMA; CQQLRLH; -.
DR   OrthoDB; 1618114at2759; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0032391; C:photoreceptor connecting cilium; IEA:Ensembl.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
DR   GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR   GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR   GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:Ensembl.
DR   Gene3D; 1.20.58.1250; -; 1.
DR   Gene3D; 2.160.20.70; -; 1.
DR   InterPro; IPR017901; C-CAP_CF_C-like.
DR   InterPro; IPR016098; CAP/MinC_C.
DR   InterPro; IPR006599; CARP_motif.
DR   InterPro; IPR027684; TBCC.
DR   InterPro; IPR031925; TBCC_N.
DR   InterPro; IPR038397; TBCC_N_sf.
DR   InterPro; IPR012945; Tubulin-bd_cofactor_C_dom.
DR   PANTHER; PTHR15139; PTHR15139; 1.
DR   Pfam; PF07986; TBCC; 1.
DR   Pfam; PF16752; TBCC_N; 1.
DR   PIRSF; PIRSF037947; Protein_XRP2_; 1.
DR   SMART; SM00673; CARP; 2.
DR   PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   GTP-binding {ECO:0000256|PIRSR:PIRSR037947-1};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR037947-1};
KW   Proteomics identification {ECO:0000213|EPD:A0A0R4J0M1,
KW   ECO:0000213|MaxQB:A0A0R4J0M1, ECO:0000213|PeptideAtlas:A0A0R4J0M1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN      163    318       C-CAP/cofactor C-like.
FT                                {ECO:0000259|PROSITE:PS51329}.
FT   NP_BIND     254    257       GTP. {ECO:0000256|PIRSR:PIRSR037947-1}.
FT   REGION       34     55       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0R4J0M1}.
FT   REGION      149    173       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0R4J0M1}.
FT   COILED       80    100       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   341 AA;  38095 MW;  D1160B6A89ACF97B CRC64;
     MEGVDCSMAL ADAAAGSPRD LSLVPERLQR REQERQIEVE RRKQKRQDQE VEEEKSGFFA
     AAFARERAAV EELLRGEASA ERLEEAANRL QGLRKLLNDS VLFLAAYDLR QGQAALAQLQ
     AVLTERRQEL QPKKRFAFKA RKKDAAGTAQ VDAAPVASAA PSPPVTKEEE GAPGASWACG
     FSNLESQDLE KRAEELHQRD VLLSDLTNCT VKLCGNPNTL RLAKARGCKV LCGPVTTSVF
     LEDCRDCVLA VACQQLRVHT TKDTRVFLQV TSRAIVEDCS GIQFAPYTWS YPGIDKDFQD
     SGLDRSKNNW DQVDDFNWLA RNVASPNWSI LPEEERDIQW D
//
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